Silicone Oil- and Agitation-Induced Aggregation of a Monoclonal Antibody in Aqueous Solution
Thirumangalathu, Renuka, Krishnan, Sampathkumar, Ricci, Margaret Speed, Brems, David N., Randolph, Theodore W., Carpenter, John F.
Published in Journal of pharmaceutical sciences (01.09.2009)
Published in Journal of pharmaceutical sciences (01.09.2009)
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Journal Article
Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein Aggregation
Saluja, Atul, Fesinmeyer, R. Matthew, Hogan, Sabine, Brems, David N., Gokarn, Yatin R.
Published in Biophysical journal (20.10.2010)
Published in Biophysical journal (20.10.2010)
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Journal Article
Structure and Stability Changes of Human IgG1 Fc as a Consequence of Methionine Oxidation
Liu, Dingjiang, Ren, Da, Huang, Holly, Dankberg, Jane, Rosenfeld, Robert, Cocco, Melanie J, Li, Luke, Brems, David N, Remmele, Richard L
Published in Biochemistry (Easton) (06.05.2008)
Published in Biochemistry (Easton) (06.05.2008)
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Journal Article
An improved trypsin digestion method minimizes digestion-induced modifications on proteins
Ren, Da, Pipes, Gary D., Liu, Dingjiang, Shih, Liang-Yu, Nichols, Andrew C., Treuheit, Michael J., Brems, David N., Bondarenko, Pavel V.
Published in Analytical biochemistry (01.09.2009)
Published in Analytical biochemistry (01.09.2009)
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Journal Article
Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface in dilute salt solutions
Gokarn, Yatin R., Fesinmeyer, R.Matthew, Saluja, Atul, Razinkov, Vladimir, Chase, Susan F., Laue, Thomas M., Brems, David N.
Published in Protein science (01.03.2011)
Published in Protein science (01.03.2011)
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Journal Article
Institution of an emergency department "swarming" care model and sepsis door-to-antibiotic time: A quasi-experimental retrospective analysis
Peltan, Ithan D, Bledsoe, Joseph R, Brems, David, McLean, Sierra, Murnin, Emily, Brown, Samuel M
Published in PloS one (05.05.2020)
Published in PloS one (05.05.2020)
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Journal Article
Isomerization of a Single Aspartyl Residue of Anti-Epidermal Growth Factor Receptor Immunoglobulin γ2 Antibody Highlights the Role Avidity Plays in Antibody Activity
Rehder, Douglas S, Chelius, Dirk, McAuley, Arnold, Dillon, Thomas M, Xiao, Gang, Crouse-Zeineddini, Jill, Vardanyan, Louisa, Perico, Natalie, Mukku, Venkat, Brems, David N, Matsumura, Masazumi, Bondarenko, Pavel V
Published in Biochemistry (Easton) (26.02.2008)
Published in Biochemistry (Easton) (26.02.2008)
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Journal Article
Contributions of a disulfide bond to the structure, stability, and dimerization of human IgG1 antibody CH3 domain
McAuley, Arnold, Jacob, Jaby, Kolvenbach, Carl G., Westland, Kimberly, Lee, Hyo Jin, Brych, Stephen R., Rehder, Douglas, Kleemann, Gerd R., Brems, David N., Matsumura, Masazumi
Published in Protein science (01.01.2008)
Published in Protein science (01.01.2008)
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Journal Article
Comparison of High-Throughput Biophysical Methods to Identify Stabilizing Excipients for a Model IgG2 Monoclonal Antibody: Conformational Stability and Kinetic Aggregation Measurements
Cheng, Weiqiang, Joshi, Sangeeta B., He, Feng, Brems, David N., He, Bing, Kerwin, Bruce A., Volkin, David B., Middaugh, C. Russell
Published in Journal of pharmaceutical sciences (01.05.2012)
Published in Journal of pharmaceutical sciences (01.05.2012)
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Journal Article
Inverse relationship of protein concentration and aggregation
TREUHEIT, Michael J, KOSKY, Andrew A, BREMS, David N
Published in Pharmaceutical research (01.04.2002)
Published in Pharmaceutical research (01.04.2002)
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Journal Article
Modulation of protein aggregation by polyethylene glycol conjugation: GCSF as a case study
Rajan, Rahul S., Li, Tiansheng, Aras, Mohini, Sloey, Christopher, Sutherland, Weston, Arai, Hiromi, Briddell, Robert, Kinstler, Olaf, Lueras, Alexis M.K., Zhang, Yu, Yeghnazar, Heather, Treuheit, Michael, Brems, David N.
Published in Protein science (01.05.2006)
Published in Protein science (01.05.2006)
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Journal Article
Effects of pH, Temperature, and Sucrose on Benzyl Alcohol-Induced Aggregation of Recombinant Human Granulocyte Colony Stimulating Factor
Thirumangalathu, Renuka, Krishnan, Sampathkumar, Brems, David N., Randolph, Theodore W., Carpenter, John F.
Published in Journal of pharmaceutical sciences (01.07.2006)
Published in Journal of pharmaceutical sciences (01.07.2006)
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Journal Article
Aggregation of granulocyte‐colony stimulating factor in vitro involves a conformationally altered monomeric state
Raso, Stephen W., Abel, Jeff, Barnes, Jesse M., Maloney, Kevin M., Pipes, Gary, Treuheit, Michael J., King, Jonathan, Brems, David N.
Published in Protein science (01.09.2005)
Published in Protein science (01.09.2005)
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Journal Article
Ion‐specific modulation of protein interactions: Anion‐induced, reversible oligomerization of a fusion protein
Gokarn, Yatin R., Fesinmeyer, R. Matthew, Saluja, Atul, Cao, Shawn, Dankberg, Jane, Goetze, Andrew, Jr, Richard L. Remmele, Narhi, Linda O., Brems, David N.
Published in Protein science (01.01.2009)
Published in Protein science (01.01.2009)
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Journal Article
Oxidation of Methionine Residues in Recombinant Human Interleukin-1 Receptor Antagonist: Implications of Conformational Stability on Protein Oxidation Kinetics
Thirumangalathu, Renuka, Krishnan, Sampathkumar, Bondarenko, Pavel, Speed-Ricci, Margaret, Randolph, Theodore W, Carpenter, John F, Brems, David N
Published in Biochemistry (Easton) (29.05.2007)
Published in Biochemistry (Easton) (29.05.2007)
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Journal Article
Self-Buffering Antibody Formulations
Gokarn, Yatin R., Kras, Eva, Nodgaard, Carrie, Dharmavaram, Vasumathi, Fesinmeyer, R.Matthew, Hultgen, Heather, Brych, Stephen, Remmele Jr, Richard L., Brems, David N., Hershenson, Susan
Published in Journal of pharmaceutical sciences (01.08.2008)
Published in Journal of pharmaceutical sciences (01.08.2008)
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Journal Article