Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
Krajnc, Alen, Brem, Jürgen, Hinchliffe, Philip, Calvopiña, Karina, Panduwawala, Tharindi D, Lang, Pauline A, Kamps, Jos J. A. G, Tyrrell, Jonathan M, Widlake, Emma, Saward, Benjamin G, Walsh, Timothy R, Spencer, James, Schofield, Christopher J
Published in Journal of medicinal chemistry (26.09.2019)
Published in Journal of medicinal chemistry (26.09.2019)
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An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography
Butryn, Agata, Simon, Philipp S., Aller, Pierre, Hinchliffe, Philip, Massad, Ramzi N., Leen, Gabriel, Tooke, Catherine L., Bogacz, Isabel, Kim, In-Sik, Bhowmick, Asmit, Brewster, Aaron S., Devenish, Nicholas E., Brem, Jürgen, Kamps, Jos J. A. G., Lang, Pauline A., Rabe, Patrick, Axford, Danny, Beale, John H., Davy, Bradley, Ebrahim, Ali, Orlans, Julien, Storm, Selina L. S., Zhou, Tiankun, Owada, Shigeki, Tanaka, Rie, Tono, Kensuke, Evans, Gwyndaf, Owen, Robin L., Houle, Frances A., Sauter, Nicholas K., Schofield, Christopher J., Spencer, James, Yachandra, Vittal K., Yano, Junko, Kern, Jan F., Orville, Allen M.
Published in Nature communications (22.07.2021)
Published in Nature communications (22.07.2021)
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Will morphing boron-based inhibitors beat the β-lactamases?
Krajnc, Alen, Lang, Pauline A, Panduwawala, Tharindi D, Brem, Jürgen, Schofield, Christopher J
Published in Current opinion in chemical biology (01.06.2019)
Published in Current opinion in chemical biology (01.06.2019)
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New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis
Lohans, Christopher T, Brem, Jürgen, Schofield, Christopher J
Published in Antimicrobial agents and chemotherapy (01.12.2017)
Published in Antimicrobial agents and chemotherapy (01.12.2017)
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Journal Article
In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors
Cain, Ricky, Brem, Jürgen, Zollman, David, McDonough, Michael A, Johnson, Rachel M, Spencer, James, Makena, Anne, Abboud, Martine I, Cahill, Samuel, Lee, Sook Y, McHugh, Peter J, Schofield, Christopher J, Fishwick, Colin W. G
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes
Newman, Hector, Krajnc, Alen, Bellini, Dom, Eyermann, Charles J, Boyle, Grant A, Paterson, Neil G, McAuley, Katherine E, Lesniak, Robert, Gangar, Mukesh, von Delft, Frank, Brem, Jürgen, Chibale, Kelly, Schofield, Christopher J, Dowson, Christopher G
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Journal Article
Optimized Synthesis of Indole Carboxylate Metallo-β-Lactamase Inhibitor EBL-3183
Baran, Andrei, Kuzmins, Jevgenijs, Kuznecovs, Jevgenijs, Farley, Alistair J. M., Panduwawala, Tharindi, Parkova, Anete, Donets, Pavel A., Brem, Jürgen, Suna, Edgars, Schofield, Christopher J., Shubin, Kirill
Published in Organic process research & development (21.04.2023)
Published in Organic process research & development (21.04.2023)
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Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
Brem, Jürgen, Cain, Ricky, Cahill, Samuel, McDonough, Michael A., Clifton, Ian J., Jiménez-Castellanos, Juan-Carlos, Avison, Matthew B., Spencer, James, Fishwick, Colin W. G., Schofield, Christopher J.
Published in Nature communications (08.08.2016)
Published in Nature communications (08.08.2016)
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Mapping the Hydrophobic Substrate Binding Site of Phenylalanine Ammonia-Lyase from Petroselinum crispum
Nagy, Emma Z. A, Tork, Souad D, Lang, Pauline A, Filip, Alina, Irimie, Florin D, Poppe, László, Toşa, Monica I, Schofield, Christopher J, Brem, Jürgen, Paizs, Csaba, Bencze, László C
Published in ACS catalysis (06.09.2019)
Published in ACS catalysis (06.09.2019)
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Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1
Hinchliffe, Philip, Yang, Qiu E., Portal, Edward, Young, Tom, Li, Hui, Tooke, Catherine L., Carvalho, Maria J., Paterson, Neil G., Brem, Jürgen, Niumsup, Pannika R., Tansawai, Uttapoln, Lei, Lei, Li, Mei, Shen, Zhangqi, Wang, Yang, Schofield, Christopher J., Mulholland, Adrian J, Shen, Jianzhong, Fey, Natalie, Walsh, Timothy R., Spencer, James
Published in Scientific reports (06.01.2017)
Published in Scientific reports (06.01.2017)
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Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
Brem, Jürgen, Panduwawala, Tharindi, Hansen, Jon Ulf, Hewitt, Joanne, Liepins, Edgars, Donets, Pawel, Espina, Laura, Farley, Alistair J. M., Shubin, Kirill, Campillos, Gonzalo Gomez, Kiuru, Paula, Shishodia, Shifali, Krahn, Daniel, Leśniak, Robert K., Schmidt (Adrian), Juliane, Calvopiña, Karina, Turrientes, María-Carmen, Kavanagh, Madeline E., Lubriks, Dmitrijs, Hinchliffe, Philip, Langley, Gareth W., Aboklaish, Ali F., Eneroth, Anders, Backlund, Maria, Baran, Andrei G., Nielsen, Elisabet I., Speake, Michael, Kuka, Janis, Robinson, John, Grinberga, Solveiga, Robinson, Lindsay, McDonough, Michael A., Rydzik, Anna M., Leissing, Thomas M., Jimenez-Castellanos, Juan Carlos, Avison, Matthew B., Da Silva Pinto, Solange, Pannifer, Andrew D., Martjuga, Marina, Widlake, Emma, Priede, Martins, Hopkins Navratilova, Iva, Gniadkowski, Marek, Belfrage, Anna Karin, Brandt, Peter, Yli-Kauhaluoma, Jari, Bacque, Eric, Page, Malcolm G. P., Björkling, Fredrik, Tyrrell, Jonathan M., Spencer, James, Lang, Pauline A., Baranczewski, Pawel, Cantón, Rafael, McElroy, Stuart P., Jones, Philip S., Baquero, Fernando, Suna, Edgars, Morrison, Angus, Walsh, Timothy R., Schofield, Christopher J.
Published in Nature chemistry (01.01.2022)
Published in Nature chemistry (01.01.2022)
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In vitro efficacy of imipenem-relebactam and cefepime-AAI101 against a global collection of ESBL-positive and carbapenemase-producing Enterobacteriaceae
Tselepis, Lucas, Langley, Gareth W., Aboklaish, Ali F., Widlake, Emma, Jackson, Dana E., Walsh, Timothy R., Schofield, Chris J., Brem, Jürgen, Tyrrell, Jonathan M.
Published in International journal of antimicrobial agents (01.07.2020)
Published in International journal of antimicrobial agents (01.07.2020)
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Journal Article
Interaction of Avibactam with Class B Metallo-β-Lactamases
Abboud, Martine I, Damblon, Christian, Brem, Jürgen, Smargiasso, Nicolas, Mercuri, Paola, Gilbert, Bernard, Rydzik, Anna M, Claridge, Timothy D W, Schofield, Christopher J, Frère, Jean-Marie
Published in Antimicrobial agents and chemotherapy (01.10.2016)
Published in Antimicrobial agents and chemotherapy (01.10.2016)
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NMR-filtered virtual screening leads to non-metal chelating metallo-beta-lactamase inhibitors
Li, Guo-Bo, Abboud, Martine I., Brem, Jurgen, Someya, Hidenori, Lohans, Christopher T., Yang, Sheng-Yong, Spencer, James, Wareham, David W., McDonough, Michael A., Schofield, Christopher J.
Published in Chemical science (Cambridge) (01.02.2017)
Published in Chemical science (Cambridge) (01.02.2017)
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Journal Article
A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation
Lohans, Christopher T., van Groesen, Emma, Kumar, Kiran, Tooke, Catherine L., Spencer, James, Paton, Robert S., Brem, Jürgen, Schofield, Christopher J.
Published in Angewandte Chemie International Edition (26.01.2018)
Published in Angewandte Chemie International Edition (26.01.2018)
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Journal Article
Profiling interactions of vaborbactam with metallo-β-lactamases
Langley, Gareth W., Cain, Ricky, Tyrrell, Jonathan M., Hinchliffe, Philip, Calvopiña, Karina, Tooke, Catherine L., Widlake, Emma, Dowson, Christopher G., Spencer, James, Walsh, Timothy R., Schofield, Christopher J., Brem, Jürgen
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
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Journal Article
Crystal structures of VIM‐1 complexes explain active site heterogeneity in VIM‐class metallo‐β‐lactamases
Salimraj, Ramya, Hinchliffe, Philip, Kosmopoulou, Magda, Tyrrell, Jonathan M., Brem, Jürgen, Berkel, Sander S., Verma, Anil, Owens, Raymond J., McDonough, Michael A., Walsh, Timothy R., Schofield, Christopher J., Spencer, James
Published in The FEBS journal (01.01.2019)
Published in The FEBS journal (01.01.2019)
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High-throughput screen with the l,d-transpeptidase LdtMt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors
de Munnik, Mariska, Lang, Pauline A, De Dios Anton, Francisco, Cacho, Mónica, Bates, Robert H, Brem, Jürgen, Beatriz Rodríguez Miquel, Schofield, Christopher J
Published in Chemical science (Cambridge) (05.07.2023)
Published in Chemical science (Cambridge) (05.07.2023)
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