Force-Sensitive Autoinhibition of the von Willebrand Factor Is Mediated by Interdomain Interactions
Aponte-Santamaría, Camilo, Huck, Volker, Posch, Sandra, Bronowska, Agnieszka K., Grässle, Sandra, Brehm, Maria A., Obser, Tobias, Schneppenheim, Reinhard, Hinterdorfer, Peter, Schneider, Stefan W., Baldauf, Carsten, Gräter, Frauke
Published in Biophysical journal (05.05.2015)
Published in Biophysical journal (05.05.2015)
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The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction
Schneppenheim, Reinhard, Hellermann, Natalie, Brehm, Maria A., Klemm, Ulrike, Obser, Tobias, Huck, Volker, Schneider, Stefan W., Denis, Cécile V., Tischer, Alexander, Auton, Matthew, März, Winfried, Xu, Emma-Ruoqi, Wilmanns, Matthias, Zotz, Rainer B.
Published in Blood (24.01.2019)
Published in Blood (24.01.2019)
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Upshaw-Schulman syndrome-associated ADAMTS13 variants possess proteolytic activity at the surface of endothelial cells and in simulated circulation
Letzer, Anton, Lehmann, Katja, Mess, Christian, König, Gesa, Obser, Tobias, Peine, Sven, Schneppenheim, Sonja, Budde, Ulrich, Schneider, Stefan W, Schneppenheim, Reinhard, Brehm, Maria A
Published in PloS one (04.05.2020)
Published in PloS one (04.05.2020)
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von Willebrand factor is dimerized by protein disulfide isomerase
Lippok, Svenja, Kolšek, Katra, Löf, Achim, Eggert, Dennis, Vanderlinden, Willem, Müller, Jochen P., König, Gesa, Obser, Tobias, Röhrs, Karoline, Schneppenheim, Sonja, Budde, Ulrich, Baldauf, Carsten, Aponte-Santamaría, Camilo, Gräter, Frauke, Schneppenheim, Reinhard, Rädler, Joachim O., Brehm, Maria A.
Published in Blood (03.03.2016)
Published in Blood (03.03.2016)
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Advancing multimer analysis of von Willebrand factor by single-molecule AFM imaging
Löf, Achim, König, Gesa, Schneppenheim, Sonja, Schneppenheim, Reinhard, Benoit, Martin, Budde, Ulrich, Müller, Jochen P, Brehm, Maria A
Published in PloS one (15.01.2019)
Published in PloS one (15.01.2019)
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Von Willebrand Factor Mediates Pneumococcal Aggregation and Adhesion in Blood Flow
Jagau, Hilger, Behrens, Ina-Kristin, Lahme, Karen, Lorz, Georgina, Köster, Reinhard W, Schneppenheim, Reinhard, Obser, Tobias, Brehm, Maria A, König, Gesa, Kohler, Thomas P, Rohde, Manfred, Frank, Ronald, Tegge, Werner, Fulde, Marcus, Hammerschmidt, Sven, Steinert, Michael, Bergmann, Simone
Published in Frontiers in microbiology (26.03.2019)
Published in Frontiers in microbiology (26.03.2019)
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von Willebrand disease type 2A phenotypes IIC, IID and IIE: A day in the life of shear-stressed mutant von Willebrand factor
Brehm, M A, Huck, V, Aponte-Santamaría, C, Obser, T, Grässle, S, Oyen, F, Budde, U, Schneppenheim, S, Baldauf, C, Gräter, F, Schneider, S W, Schneppenheim, R
Published in Thrombosis and haemostasis (2014)
Published in Thrombosis and haemostasis (2014)
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A biophysical view on von Willebrand factor activation
Löf, Achim, Müller, Jochen P., Brehm, Maria A.
Published in Journal of cellular physiology (01.02.2018)
Published in Journal of cellular physiology (01.02.2018)
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Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor
Löf, Achim, Walker, Philipp U., Sedlak, Steffen M., Gruber, Sophia, Obser, Tobias, Brehm, Maria A., Benoit, Martin, Lipfert, Jan
Published in Proceedings of the National Academy of Sciences - PNAS (17.09.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (17.09.2019)
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Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase
Brehm, Maria A, Schenk, Tobias M H, Zhou, Xuefei, Fanick, Werner, Lin, Hongying, Windhorst, Sabine, Nalaskowski, Marcus M, Kobras, Mario, Shears, Stephen B, Mayr, Georg W
Published in Biochemical journal (15.12.2007)
Published in Biochemical journal (15.12.2007)
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Alteration in GPIIb/IIIa Binding of VWD-Associated von Willebrand Factor Variants with C-Terminal Missense Mutations
König, Gesa, Obser, Tobias, Marggraf, Olivier, Schneppenheim, Sonja, Budde, Ulrich, Schneppenheim, Reinhard, Brehm, Maria A
Published in Thrombosis and haemostasis (01.07.2019)
Published in Thrombosis and haemostasis (01.07.2019)
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Identification of the actin-binding domain of Ins(1,4,5)P3 3-kinase isoform B (IP3K-B)
Brehm, Maria A, Schreiber, Isabell, Bertsch, Uwe, Wegner, Albrecht, Mayr, Georg W
Published in Biochemical journal (15.08.2004)
Published in Biochemical journal (15.08.2004)
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Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factor
Posch, Sandra, Aponte-Santamaría, Camilo, Schwarzl, Richard, Karner, Andreas, Radtke, Matthias, Gräter, Frauke, Obser, Tobias, König, Gesa, Brehm, Maria A., Gruber, Hermann J., Netz, Roland R., Baldauf, Carsten, Schneppenheim, Reinhard, Tampé, Robert, Hinterdorfer, Peter
Published in Data in brief (01.09.2016)
Published in Data in brief (01.09.2016)
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DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions
Sandoval-Pérez, Angélica, Berger, Ricarda M L, Garaizar, Adiran, Farr, Stephen E, Brehm, Maria A, König, Gesa, Schneider, Stefan W, Collepardo-Guevara, Rosana, Huck, Volker, Rädler, Joachim O, Aponte-Santamaría, Camilo
Published in Nucleic acids research (27.07.2020)
Published in Nucleic acids research (27.07.2020)
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Journal Article
Structure and dynamics of the von Willebrand Factor C6 domain
Chen, Po-chia, Kutzki, Fabian, Mojzisch, Angelika, Simon, Bernd, Xu, Emma-Ruoqi, Aponte-Santamaría, Camilo, Horny, Kai, Jeffries, Cy, Schneppenheim, Reinhard, Wilmanns, Matthias, Brehm, Maria A., Gräter, Frauke, Hennig, Janosch
Published in Journal of structural biology (01.12.2022)
Published in Journal of structural biology (01.12.2022)
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Journal Article
Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping
Tischer, Alexander, Machha, Venkata R., Frontroth, Juan P., Brehm, Maria A., Obser, Tobias, Schneppenheim, Reinhard, Mayne, Leland, Walter Englander, S., Auton, Matthew
Published in Journal of molecular biology (07.07.2017)
Published in Journal of molecular biology (07.07.2017)
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