Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis
Coakley, John D, Breen, Eamon P, Moreno-Olivera, Ana, Al-Harbi, Alhanouf I, Melo, Ashanty M, O'Connell, Brian, McManus, Ross, Doherty, Derek G, Ryan, Thomas
Published in PloS one (28.10.2019)
Published in PloS one (28.10.2019)
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Trained immunity is induced in humans after immunization with an adenoviral vector COVID-19 vaccine
Murphy, Dearbhla M, Cox, Donal J, Connolly, Sarah A, Breen, Eamon P, Brugman, Aenea Ai, Phelan, James J, Keane, Joseph, Basdeo, Sharee A
Published in The Journal of clinical investigation (15.01.2023)
Published in The Journal of clinical investigation (15.01.2023)
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Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia
Larkin, Caroline M, Hante, Nadhim Kamil, Breen, Eamon P, Tomaszewski, Krzysztof A, Eisele, Simon, Radomski, Marek W, Ryan, Thomas A, Santos-Martinez, Maria-Jose
Published in PloS one (07.05.2018)
Published in PloS one (07.05.2018)
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Human Vδ3+ γδ T cells induce maturation and IgM secretion by B cells
Petrasca, Andreea, Melo, Ashanty M., Breen, Eamon P., Doherty, Derek G.
Published in Immunology letters (01.04.2018)
Published in Immunology letters (01.04.2018)
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The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3
Higgs, Rowan, Ní Gabhann, Joan, Ben Larbi, Nadia, Breen, Eamon P, Fitzgerald, Katherine A, Jefferies, Caroline A
Published in The Journal of immunology (1950) (01.08.2008)
Published in The Journal of immunology (1950) (01.08.2008)
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von Willebrand factor links primary hemostasis to innate immunity
Drakeford, Clive, Aguila, Sonia, Roche, Fiona, Hokamp, Karsten, Fazavana, Judicael, Cervantes, Mariana P., Curtis, Annie M., Hawerkamp, Heike C., Dhami, Sukhraj Pal Singh, Charles-Messance, Hugo, Hackett, Emer E., Chion, Alain, Ward, Soracha, Ahmad, Azaz, Schoen, Ingmar, Breen, Eamon, Keane, Joe, Murphy, Ross, Preston, Roger J. S., O’Sullivan, Jamie M., Sheedy, Frederick J., Fallon, Padraic, O’Donnell, James S.
Published in Nature communications (03.11.2022)
Published in Nature communications (03.11.2022)
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Hepatocyte entry leads to degradation of autoreactive CD8 T cells
Benseler, Volker, Warren, Alessandra, Vo, Michelle, Holz, Lauren E, Tay, Szun S, Le Couteur, David G, Breen, Eamon, Allison, Anthony C, van Rooijen, Nico, McGuffog, Claire, Schlitt, Hans J, Bowen, David G, McCaughan, Geoffrey W, Bertolino, Patrick
Published in Proceedings of the National Academy of Sciences - PNAS (04.10.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (04.10.2011)
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CD1d expression and invariant natural killer T-cell numbers are reduced in patients with upper gastrointestinal cancers and are further impaired by commonly used chemotherapies
Melo, Ashanty M., Conroy, Melissa J., Foley, Emma K., Dockry, Éilis, Breen, Eamon P., Reynolds, John V., Lysaght, Joanne, Doherty, Derek G.
Published in Cancer Immunology, Immunotherapy (01.06.2020)
Published in Cancer Immunology, Immunotherapy (01.06.2020)
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Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin
MacDonagh, Lauren, Santiago, Rhyla Mae, Gray, Steven G., Breen, Eamon, Cuffe, Sinead, Finn, Stephen P., O'Byrne, Kenneth J., Barr, Martin P.
Published in Translational oncology (01.04.2021)
Published in Translational oncology (01.04.2021)
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Novel thioglycoside analogs of α-galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells
Melo, Ashanty M, Zhang, Lei, Dockry, Éilis F, Petrasca, Andreea, Ghnewa, Yasmeen G, Breen, Eamon P, Morrissey, Maria E, O'Reilly, Ciara, Bruen, Robyn, O'Meara, Andrew, Lysaght, Joanne, Zhu, Xiangming, Doherty, Derek G
Published in Glycobiology (Oxford) (01.07.2018)
Published in Glycobiology (Oxford) (01.07.2018)
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Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation
Brennan, Kiva, O'Leary, Bobby D, Mc Laughlin, Danielle, Breen, Eamon P, Connolly, Emma, Ali, Nusrat, O'Driscoll, David N, Ozaki, Ema, Mahony, Rebecca, Mulfaul, Kelly, Ryan, Aoife M, Ni Chianain, Aine, McHugh, Alison, Molloy, Eleanor J, Hogan, Andrew E, Paran, Sri, McAuliffe, Fionnuala M, Doyle, Sarah L
Published in The Journal of immunology (1950) (15.08.2018)
Published in The Journal of immunology (1950) (15.08.2018)
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Platelet microaggregation in sepsis examined by quartz crystal microbalance with dissipation technology
Larkin, Caroline M, Breen, Eamon P, Tomaszewski, Krzysztof A, Eisele, Simon, Radomski, Marek W, Ryan, Thomas A, Santos-Martinez, Maria-Jose
Published in Platelets (Edinburgh) (01.05.2018)
Published in Platelets (Edinburgh) (01.05.2018)
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Journal Article
Innate Lymphocyte Th1 and Th17 Responses in Elderly Hospitalised Patients with Infection and Sepsis
Coakley, John Davis, Breen, Eamon P., Moreno-Olivera, Ana, Al-Harbi, Alhanouf I., Melo, Ashanty M., O’Connell, Brian, McManus, Ross, Doherty, Derek G., Ryan, Thomas
Published in Vaccines (Basel) (17.06.2020)
Published in Vaccines (Basel) (17.06.2020)
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pSTAT3 Levels Have Divergent Expression Patterns and Associations with Survival in Squamous Cell Carcinoma and Adenocarcinoma of the Oesophagus
O' Sullivan, Katie E, Michielsen, Adriana J, O' Regan, Esther, Cathcart, Mary C, Moore, Gillian, Breen, Eamon, Segurado, Ricardo, Reynolds, John V, Lysaght, Joanne, O' Sullivan, Jacintha
Published in International journal of molecular sciences (10.06.2018)
Published in International journal of molecular sciences (10.06.2018)
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Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells
Azzu, Vian, Affourtit, Charles, Breen, Eamon P., Parker, Nadeene, Brand, Martin D.
Published in Biochimica et biophysica acta (01.10.2008)
Published in Biochimica et biophysica acta (01.10.2008)
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Study protocol for the St James's Hospital, Tallaght University Hospital, Trinity College Dublin Allied Researchers' (STTAR) Bioresource for COVID-19
O'Doherty, Laura, Hendricken Phelan, Stuart, Wood, Nicole, O'Brien, Sorcha, Sui, Jacklyn, Mangan, Cian, Howley, Fergal, O'Regan, Siobhan, Razif, Noor Adeebah Mohamed, Conlan, Ciara, Argue, Ruth, Holohan, Samuel, Dyer, Adam, Salleh, Fara, Townsend, Liam, Hughes, Gerard, Kerr, Colm, Reidy, Derval, Sanz, Alberto, Connolly, Emma, Kelly, Andrea, Leacy, Emma, Reddy, Conor, Gargan, Siobhan, Breen, Eamon, Hawerkamp, Heike, Dunne, Jean, Martin-Loeches, Ignacio, McLaughlin, Anne Marie, Long, Aideen, Shiels, Orla, Fallon, Padraic, Hennessy, Martina, Romero-Ortuno, Roman, Bannan, Ciaran, Prior, Anna Rose, Rakovac, Ana, McCormack, William, McManus, Ross, Donnelly, Seamus, Bergin, Colm, Little, Mark, Ní Cheallaigh, Clíona, Conlon, Niall
Published in HRB open research (2022)
Published in HRB open research (2022)
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A new automated technique for the reconstitution of hydrophobic proteins into planar bilayer membranes. Studies of human recombinant uncoupling protein 1
Beck, Valeri, Jabůrek, Martin, Breen, Eamon P., Porter, Richard K., Ježek, Petr, Pohl, Elena E.
Published in Biochimica et biophysica acta (01.05.2006)
Published in Biochimica et biophysica acta (01.05.2006)
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Identification of a Functioning Mitochondrial Uncoupling Protein 1 in Thymus
Carroll, Audrey M., Haines, Lee R., Pearson, Terry W., Fallon, Padraic G., Walsh, Caitríona M., Brennan, Clare M., Breen, Eamon P., Porter, Richard K.
Published in The Journal of biological chemistry (22.04.2005)
Published in The Journal of biological chemistry (22.04.2005)
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On the Mechanism of Mitochondrial Uncoupling Protein 1 Function
Breen, Eamon P., Gouin, Sebastien G., Murphy, Andrew F., Haines, Lee R., Jackson, Angela M., Pearson, Terry W., Murphy, Paul V., Porter, Richard K.
Published in The Journal of biological chemistry (27.01.2006)
Published in The Journal of biological chemistry (27.01.2006)
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