Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins
O'Neill, Paul M, Amewu, Richard K, Nixon, Gemma L, Bousejra ElGarah, Fatima, Mungthin, Mathirut, Chadwick, James, Shone, Alison E, Vivas, Livia, Lander, Hollie, Barton, Victoria, Muangnoicharoen, Sant, Bray, Patrick G, Davies, Jill, Park, B. Kevin, Wittlin, Sergio, Brun, Reto, Preschel, Michael, Zhang, Kesheng, Ward, Stephen A
Published in Angewandte Chemie (International ed.) (02.08.2010)
Published in Angewandte Chemie (International ed.) (02.08.2010)
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Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance
Bray, Patrick G., Martin, Rowena E., Tilley, Leann, Ward, Stephen A., Kirk, Kiaran, Fidock, David A.
Published in Molecular microbiology (01.04.2005)
Published in Molecular microbiology (01.04.2005)
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Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress
van Schalkwyk, Donelly A, Saliba, Kevin J, Biagini, Giancarlo A, Bray, Patrick G, Kirk, Kiaran
Published in PloS one (11.03.2013)
Published in PloS one (11.03.2013)
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Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs
Stocks, Paul A., Bray, Patrick G., Barton, Victoria E., Al‐Helal, Mohammed, Jones, Michael, Araujo, Nuna C., Gibbons, Peter, Ward, Stephen A., Hughes, Ruth H., Biagini, Giancarlo A., Davies, Jill, Amewu, Richard, Mercer, Amy E., Ellis, Gemma, O'Neill, Paul M.
Published in Angewandte Chemie International Edition (01.01.2007)
Published in Angewandte Chemie International Edition (01.01.2007)
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A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance
Lakshmanan, Viswanathan, Bray, Patrick G, Verdier-Pinard, Dominik, Johnson, David J, Horrocks, Paul, Muhle, Rebecca A, Alakpa, George E, Hughes, Ruth H, Ward, Steve A, Krogstad, Donald J, Sidhu, Amar Bir Singh, Fidock, David A
Published in The EMBO journal (06.07.2005)
Published in The EMBO journal (06.07.2005)
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Journal Article
Evidence for a Central Role for PfCRT in Conferring Plasmodium falciparum Resistance to Diverse Antimalarial Agents
Johnson, David J., Fidock, David A., Mungthin, Mathirut, Lakshmanan, Viswanathan, Sidhu, Amar Bir Singh, Bray, Patrick G., Ward, Stephen A.
Published in Molecular cell (24.09.2004)
Published in Molecular cell (24.09.2004)
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Pentamidine uptake and resistance in pathogenic protozoa: past, present and future
Bray, Patrick G., Barrett, Michael P., Ward, Stephen A., de Koning, Harry P.
Published in Trends in parasitology (01.05.2003)
Published in Trends in parasitology (01.05.2003)
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Acridinediones: Selective and Potent Inhibitors of the Malaria Parasite Mitochondrial bc1 Complex
Biagini, Giancarlo A, Fisher, Nicholas, Berry, Neil, Stocks, Paul A, Meunier, Brigitte, Williams, Dominic P, Bonar-Law, Richard, Bray, Patrick G, Owen, Andrew, O'Neill, Paul M, Ward, Stephen A
Published in Molecular pharmacology (01.05.2008)
Published in Molecular pharmacology (01.05.2008)
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Journal Article
Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century
O’Neill, Paul M, Park, B. Kevin, Shone, Alison E, Maggs, James L, Roberts, Phillip, Stocks, Paul A, Biagini, Giancarlo A, Bray, Patrick G, Gibbons, Peter, Berry, Neil, Winstanley, Peter A, Mukhtar, Amira, Bonar-Law, Richard, Hindley, Stephen, Bambal, Ramesh B, Davis, Charles B, Bates, Martin, Hart, Timothy K, Gresham, Stephanie L, Lawrence, Ron M, Brigandi, Richard A, Gomez-delas-Heras, Federico M, Gargallo, Domingo V, Ward, Stephen A
Published in Journal of medicinal chemistry (12.03.2009)
Published in Journal of medicinal chemistry (12.03.2009)
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Journal Article
Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum
Chaijaroenkul, Wanna, Ward, Stephen A, Mungthin, Mathirut, Johnson, David, Owen, Andrew, Bray, Patrick G, Na-Bangchang, Kesara
Published in Malaria journal (15.02.2011)
Published in Malaria journal (15.02.2011)
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Journal Article
PfCRT and the trans‐vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX
Bray, Patrick G., Mungthin, Mathirut, Hastings, Ian M., Biagini, Giancarlo A., Saidu, Dauda K., Lakshmanan, Viswanathan, Johnson, David J., Hughes, Ruth H., Stocks, Paul A., O'Neill, Paul M., Fidock, David A., Warhurst, David C., Ward, Stephen A.
Published in Molecular microbiology (01.10.2006)
Published in Molecular microbiology (01.10.2006)
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Antitumour and antimalarial activity of artemisinin-acridine hybrids
JONES, Michael, MERCER, Amy E, BRAY, Patrick G, RAWE, Sarah L, BAIRD, Jonathan, CHARIDZA, Tafadzwa, JANNEH, Omar, O'NEILL, Paul M, STOCKS, Paul A, LA PENSEE, Louise J. I, COSSTICK, Rick, PARK, B. Kevin, KENNEDY, Miriam E, PIANTANIDA, Ivo, WARD, Stephen A, DAVIES, Jill
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
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A comprehensive model of purine uptake by the malaria parasite Plasmodium falciparum: identification of four purine transport activities in intraerythrocytic parasites
Quashie, Neils B, Dorin-Semblat, Dominique, Bray, Patrick G, Biagini, Giancarlo A, Doerig, Christian, Ranford-Cartwright, Lisa C, De Koning, Harry P
Published in Biochemical journal (15.04.2008)
Published in Biochemical journal (15.04.2008)
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Journal Article
Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics
Arshad, Usman, Pertinez, Henry, Box, Helen, Tatham, Lee, Rajoli, Rajith K. R., Curley, Paul, Neary, Megan, Sharp, Joanne, Liptrott, Neill J., Valentijn, Anthony, David, Christopher, Rannard, Steve P., O’Neill, Paul M., Aljayyoussi, Ghaith, Pennington, Shaun H., Ward, Stephen A., Hill, Andrew, Back, David J., Khoo, Saye H., Bray, Patrick G., Biagini, Giancarlo A., Owen, Andrew
Published in Clinical pharmacology and therapeutics (01.10.2020)
Published in Clinical pharmacology and therapeutics (01.10.2020)
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P-glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells : potential for accelerated viral drug resistance?
JONES, Kevin, BRAY, Patrick G, KHOO, Saye H, DAVEY, Ross A, MEADEN, E. Rhiannon, WARD, Stephen A, BACK, David J
Published in AIDS (London) (27.07.2001)
Published in AIDS (London) (27.07.2001)
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Heme Binding Contributes to Antimalarial Activity of Bis-Quaternary Ammoniums
Biagini, Giancarlo A, Richier, Eric, Bray, Patrick G, Calas, Michèle, Vial, Henri, Ward, Stephen A
Published in Antimicrobial Agents and Chemotherapy (01.08.2003)
Published in Antimicrobial Agents and Chemotherapy (01.08.2003)
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Journal Article
Enantiomeric 1,2,4-Trioxanes Display Equivalent in vitro Antimalarial Activity Versus Plasmodium falciparum Malaria Parasites: Implications for the Molecular Mechanism of Action of the Artemisinins
O'Neill, Paul M, Rawe, Sarah L, Borstnik, Kristina, Miller, Alison, Ward, Stephen A, Bray, Patrick G, Davies, Jill, Oh, Chang Ho, Posner, Gary H
Published in Chembiochem : a European journal of chemical biology (01.11.2005)
Published in Chembiochem : a European journal of chemical biology (01.11.2005)
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