Targeting Mitosis in Cancer: Emerging Strategies
Dominguez-Brauer, Carmen, Thu, Kelsie L., Mason, Jacqueline M., Blaser, Heiko, Bray, Mark R., Mak, Tak W.
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Published in Molecular cell (19.11.2015)
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Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent
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Published in Cancer cell (11.08.2014)
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Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer
Mason, Jacqueline M., Wei, Xin, Fletcher, Graham C., Kiarash, Reza, Brokx, Richard, Hodgson, Richard, Beletskaya, Irina, Bray, Mark R., Mak, Tak W.
Published in Proceedings of the National Academy of Sciences - PNAS (21.03.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (21.03.2017)
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Fcmr regulates mononuclear phagocyte control of anti-tumor immunity
Kubli, Shawn P, Vornholz, Larsen, Duncan, Gordon, Zhou, Wenjing, Ramachandran, Parameswaran, Fortin, Jerome, Cox, Maureen, Han, SeongJun, Nechanitzky, Robert, Nechanitzky, Duygu, Snow, Bryan E, Jones, Lisa, Li, Wanda Y, Haight, Jillian, Wakeham, Andrew, Bray, Mark R, Mak, Tak W
Published in Nature communications (18.06.2019)
Published in Nature communications (18.06.2019)
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The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3‑(4-(heterocyclyl)phenyl)‑1H‑indazole-5-carboxamides as Anticancer Agents
Liu, Yong, Lang, Yunhui, Patel, Narendra Kumar, Ng, Grace, Laufer, Radoslaw, Li, Sze-Wan, Edwards, Louise, Forrest, Bryan, Sampson, Peter B, Feher, Miklos, Ban, Fuqiang, Awrey, Donald E, Beletskaya, Irina, Mao, Guodong, Hodgson, Richard, Plotnikova, Olga, Qiu, Wei, Chirgadze, Nickolay Y, Mason, Jacqueline M, Wei, Xin, Lin, Dan Chi-Chia, Che, Yi, Kiarash, Reza, Madeira, Brian, Fletcher, Graham C, Mak, Tak W, Bray, Mark R, Pauls, Henry W
Published in Journal of medicinal chemistry (23.04.2015)
Published in Journal of medicinal chemistry (23.04.2015)
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2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation
Duncan, Gordon S., Brenner, Dirk, Tusche, Michael W., Brüstle, Anne, Knobbe, Christiane B., Elia, Andrew J., Mock, Thomas, Bray, Mark R., Krammer, Peter H., Mak, Tak W.
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2012)
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Author Correction: Fcmr regulates mononuclear phagocyte control of anti-tumor immunity
Kubli, Shawn P, Vornholz, Larsen, Duncan, Gordon, Zhou, Wenjing, Ramachandran, Parameswaran, Fortin, Jerome, Cox, Maureen, Han, SeongJun, Nechanitzky, Robert, Nechanitzky, Duygu, Snow, Bryan E, Jones, Lisa, Li, Wanda Y, Haight, Jillian, Wakeham, Andrew, Bray, Mark R, Mak, Tak W
Published in Nature communications (03.09.2019)
Published in Nature communications (03.09.2019)
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Predictive Biomarkers of Sensitivity to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Breast Cancer Models
DIAMOND, Jennifer R, GAIL ECKHARDT, S, FLETCHER, Graham C, TENTLER, John J, CHOON TAN, Aik, NEWTON, Timothy P, SELBY, Heather M, BRUNKOW, Kelsey L, KACHAEVA, Maria I, VARELLA-GARCIA, Marileila, PITTS, Todd M, BRAY, Mark R
Published in Clinical cancer research (01.01.2013)
Published in Clinical cancer research (01.01.2013)
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ENMD-2076, an oral inhibitor of angiogenic and proliferation kinases, has activity in recurrent, platinum resistant ovarian cancer
Matulonis, Ursula A, Lee, Julie, Lasonde, Brian, Tew, William P, Yehwalashet, Afra, Matei, Daniela, Behbakht, Kian, Grothusen, Jill, Fleming, Gini, Lee, Nita K, Arnott, Jamie, Bray, Mark R, Fletcher, Graham, Brokx, Richard D, Castonguay, Vincent, Mackay, Helen, Sidor, Carolyn F, Oza, Amit M
Published in European journal of cancer (1990) (01.01.2013)
Published in European journal of cancer (1990) (01.01.2013)
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Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD‐2076, against multiple myeloma
Wang, Xiaojing, Sinn, Anthony L., Pollok, Karen, Sandusky, George, Zhang, Shuhong, Chen, Li, Liang, Jing, Crean, Colin D., Suvannasankha, Attaya, Abonour, Rafat, Sidor, Carolyn, Bray, Mark R., Farag, Sherif S.
Published in British journal of haematology (01.08.2010)
Published in British journal of haematology (01.08.2010)
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Assessment of the In vivo Antitumor Effects of ENMD-2076, a Novel Multitargeted Kinase Inhibitor, against Primary and Cell Line-Derived Human Colorectal Cancer Xenograft Models
TENTLER, John J, BRADSHAW-PIERCE, Erica L, SERKOVA, Natalie J, HASEBROOCK, Kendra M, PITTS, Todd M, DIAMOND, Jennifer R, FLETCHER, Graham C, BRAY, Mark R, ECKHARDT, S. Gail
Published in Clinical cancer research (01.06.2010)
Published in Clinical cancer research (01.06.2010)
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Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial
Veitch, Zachary W, Cescon, David W, Denny, Trisha, Yonemoto, Lisa-Maria, Fletcher, Graham, Brokx, Richard, Sampson, Peter, Li, Sze-Wan, Pugh, Trevor J, Bruce, Jeffrey, Bray, Mark R, Slamon, Dennis J, Mak, Tak W, Wainberg, Zev A, Bedard, Philippe L
Published in British journal of cancer (01.08.2019)
Published in British journal of cancer (01.08.2019)
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Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma
Lee, Horace H.Y., Chow, Kin Long, Wong, Ho Shing, Chong, Tsz Yan, Wong, Alice S.T., Cheng, Grace H.W., Ko, Jasmine M.K., Siu, Hoi Cheong, Yeung, Maximus C.F., Huen, Michael S.Y., Tse, Ka Yu, Bray, Mark R., Mak, Tak Wah, Leung, Suet Yi, Ip, Philip P.C.
Published in Clinical cancer research (03.09.2024)
Published in Clinical cancer research (03.09.2024)
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Analysis of binding of the family 2a carbohydrate-binding module from Cellulomonas fimi xylanase 10A to cellulose: specificity and identification of functionally important amino acid residues
McLean, B W, Bray, M R, Boraston, A B, Gilkes, N R, Haynes, C A, Kilburn, D G
Published in Protein engineering (01.11.2000)
Published in Protein engineering (01.11.2000)
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Polo-like kinase 4 inhibitor CFI-400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity
Chan, Cerise Yuen-Ki, Yuen, Vincent Wai-Hin, Chiu, David Kung-Chun, Goh, Chi-Ching, Thu, Kelsie L, Cescon, David W, Soria-Bretones, Isabel, Law, Cheuk-Ting, Cheu, Jacinth Wing-Sum, Lee, Derek, Tse, Aki Pui-Wah, Tan, Kel Vin, Zhang, Misty Shuo, Wong, Bowie Po-Yee, Wong, Chun-Ming, Khong, Pek-Lan, Ng, Irene Oi-Lin, Bray, Mark R, Mak, Tak Wah, Yau, Thomas Chung-Cheung, Wong, Carmen Chak-Lui
Published in Hepatology (Baltimore, Md.) (01.03.2023)
Published in Hepatology (Baltimore, Md.) (01.03.2023)
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Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms
Murphy, Tracy, Mason, Jacqueline M, Leber, Brian, Bray, Mark R, Chan, Steven M, Gupta, Vikas, Khalaf, Dina, Maze, Dawn, McNamara, Caroline J, Schimmer, Aaron D, Schuh, Andre C, Sibai, Hassan, Trus, Michael, Valiquette, Debbie, Martin, Kylie, Nguyen, Linh, Li, Xuan, Mak, Tak W, Minden, Mark D, Yee, Karen W L
Published in Leukemia (01.03.2024)
Published in Leukemia (01.03.2024)
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Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification
Zhang, Christopher, Wu, Benson Z, Di Ciano-Oliveira, Caterina, Wu, Yin Fang, Khavkine Binstock, Sharon S, Soria-Bretones, Isabel, Pham, Nhu-An, Elia, Andrew J, Chari, Raj, Lam, Wan L, Bray, Mark R, Mak, Tak W, Tsao, Ming-Sound, Cescon, David W, Thu, Kelsie L
Published in Cancer gene therapy (24.08.2024)
Published in Cancer gene therapy (24.08.2024)
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ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action
Fletcher, Graham C, Brokx, Richard D, Denny, Trisha A, Hembrough, Todd A, Plum, Stacy M, Fogler, William E, Sidor, Carolyn F, Bray, Mark R
Published in Molecular cancer therapeutics (01.01.2011)
Published in Molecular cancer therapeutics (01.01.2011)
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DJ-1, a novel regulator of the tumor suppressor PTEN
Kim, Raymond H., Peters, Malte, Jang, YingJu, Shi, Wei, Pintilie, Melania, Fletcher, Graham C., DeLuca, Carmela, Liepa, Jennifer, Zhou, Lily, Snow, Bryan, Binari, Richard C., Manoukian, Armen S., Bray, Mark R., Liu, Fei-Fei, Tsao, Ming-Sound, Mak, Tak W.
Published in Cancer cell (01.03.2005)
Published in Cancer cell (01.03.2005)
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Overexpression of AKT2/protein kinase Bβ leads to up-regulation of β1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
ARBOLEDA, M. Jane, LYONS, John F, KABBINAVAR, Fairooz F, BRAY, Mark R, SNOW, Bryan E, AYALA, Raul, DANINO, Mordechai, KARLAN, Beth Y, SLAMON, Dennis J
Published in Cancer research (Chicago, Ill.) (2003)
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Published in Cancer research (Chicago, Ill.) (2003)
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