Synthesis of 2,3,4,7-tetrahydro-1H-azepines as privileged ligand scaffolds for the design of aspartic protease inhibitors via a ring-closing metathesis approach
Brass, Sascha, Chan, Nan-Si, Gerlach, Christof, Luksch, Torsten, Boettcher, Jark, Diederich, Wlibke E.
Published in Journal of organometallic chemistry (01.12.2006)
Published in Journal of organometallic chemistry (01.12.2006)
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A Small Nonrule of 3 Compatible Fragment Library Provides High Hit Rate of Endothiapepsin Crystal Structures with Various Fragment Chemotypes
Köster, Helene, Craan, Tobias, Brass, Sascha, Herhaus, Christian, Zentgraf, Matthias, Neumann, Lars, Heine, Andreas, Klebe, Gerhard
Published in Journal of medicinal chemistry (24.11.2011)
Published in Journal of medicinal chemistry (24.11.2011)
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Computer-Aided Design and Synthesis of Nonpeptidic Plasmepsin II and IV Inhibitors
Luksch, Torsten, Chan, Nan-Si, Brass, Sascha, Sotriffer, Christoph A., Klebe, Gerhard, Diederich, Wibke E.
Published in ChemMedChem (15.09.2008)
Published in ChemMedChem (15.09.2008)
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Journal Article
Fragment-Based Lead Discovery: Screening and Optimizing Fragments for Thermolysin Inhibition
Englert, Lisa, Silber, Katrin, Steuber, Holger, Brass, Sascha, Over, Björn, Gerber, Hans-Dieter, Heine, Andreas, Diederich, Wibke E., Klebe, Gerhard
Published in ChemMedChem (07.06.2010)
Published in ChemMedChem (07.06.2010)
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Unexpected Novel Binding Mode of Pyrrolidine-Based Aspartyl Protease Inhibitors: Design, Synthesis and Crystal Structure in Complex with HIV Protease
Specker, Edgar, Böttcher, Jark, Brass, Sascha, Heine, Andreas, Lilie, Hauke, Schoop, Andreas, Müller, Gerhard, Griebenow, Nils, Klebe, Gerhard
Published in ChemMedChem (16.01.2006)
Published in ChemMedChem (16.01.2006)
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Journal Article
Synthesis of 2,3,4,7-tetrahydro-1 H-azepines as privileged ligand scaffolds for the design of aspartic protease inhibitors via a ring-closing metathesis approach
Brass, Sascha, Chan, Nan-Si, Gerlach, Christof, Luksch, Torsten, Böttcher, Jark, Diederich, Wibke E.
Published in Journal of organometallic chemistry (2006)
Published in Journal of organometallic chemistry (2006)
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Journal Article
Facile Synthesis of Substituted 2,3,4,7-Tetrahydro-1H-azepines (II) via Ring-Closing Metathesis
Brass, Sascha, Gerber, Hans-Dieter, Doerr, Stefanie, Diederich, Wibke E.
Published in ChemInform (13.06.2006)
Published in ChemInform (13.06.2006)
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