Ataluren for the treatment of nonsense-mutation cystic fibrosis: a randomised, double-blind, placebo-controlled phase 3 trial
Kerem, Eitan, Konstan, Michael W, De Boeck, Kris, Accurso, Frank J, Sermet-Gaudelus, Isabelle, Wilschanski, Michael, Elborn, J Stuart, Melotti, Paola, Bronsveld, Inez, Fajac, Isabelle, Malfroot, Anne, Rosenbluth, Daniel B, Walker, Patricia A, McColley, Susanna A, Knoop, Christiane, Quattrucci, Serena, Rietschel, Ernst, Zeitlin, Pamela L, Barth, Jay, Elfring, Gary L, Welch, Ellen M, Branstrom, Arthur, Spiegel, Robert J, Peltz, Stuart W, Ajayi, Temitayo, Rowe, Steven M
Published in The lancet respiratory medicine (01.07.2014)
Published in The lancet respiratory medicine (01.07.2014)
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PTC124 targets genetic disorders caused by nonsense mutations
Chen, Guangming, Jacobson, Allan, Spatrick, Phyllis, Peltz, Stuart W, Conn, M. Morgan, Friesen, Westley J, Almstead, Neil G, Hedrick, Jean, Campbell, Jeffrey A, Mollin, Anna, Kawana, Masataka, Wilde, Richard G, Yeh, Shirley, Sweeney, H. Lee, Trotta, Christopher R, Khan, Atiyya, Welch, Ellen M, Barton, Elisabeth R, Hirawat, Samit, Turpoff, Anthony A, Weetall, Marla, Ren, Hongyu, Risher, Nicole, Tomizawa, Yuki, Northcutt, Valerie J, Miller, Langdon L, He, Feng, Jones, Stephen, Colacino, Joseph M, Feng, Huisheng, Branstrom, Arthur A, Corson, Donald, Zhuo, Jin, Ju, William D, Patel, Meenal, Moon, Young-Choon, Hwang, Seongwoo, Paushkin, Sergey, Babiak, John, Trifillis, Panayiota, Karp, Gary, Takasugi, James
Published in Nature (03.05.2007)
Published in Nature (03.05.2007)
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Ribonucleotide reductase, a novel drug target for gonorrhea
Narasimhan, Jana, Letinski, Suzanne, Jung, Stephen P, Gerasyuto, Aleksey, Wang, Jiashi, Arnold, Michael, Chen, Guangming, Hedrick, Jean, Dumble, Melissa, Ravichandran, Kanchana, Levitz, Talya, Cui, Chang, Drennan, Catherine L, Stubbe, JoAnne, Karp, Gary, Branstrom, Arthur
Published in eLife (09.02.2022)
Published in eLife (09.02.2022)
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Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent
Jernigan, Finith, Branstrom, Arthur, Baird, John D, Cao, Liangxian, Dali, Mandar, Furia, Bansri, Kim, Min Jung, O'Keefe, Kylie, Kong, Ronald, Laskin, Oscar L, Colacino, Joseph M, Pykett, Mark, Mollin, Anna, Sheedy, Josephine, Dumble, Melissa, Moon, Young-Choon, Sheridan, Richard, Mühlethaler, Tobias, Spiegel, Robert J, Prota, Andrea E, Steinmetz, Michel O, Weetall, Marla
Published in Molecular cancer therapeutics (01.10.2021)
Published in Molecular cancer therapeutics (01.10.2021)
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Inhibition of BMI1, a Therapeutic Approach in Endometrial Cancer
Buechel, Megan, Dey, Anindya, Dwivedi, Shailendra Kumar Dhar, Crim, Aleia, Ding, Kai, Zhang, Roy, Mukherjee, Priyabrata, Moore, Kathleen N, Cao, Liangxian, Branstrom, Arthur, Weetall, Marla, Baird, John, Bhattacharya, Resham
Published in Molecular cancer therapeutics (01.10.2018)
Published in Molecular cancer therapeutics (01.10.2018)
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Journal Article
Discovery and Optimization of Indolyl-Containing 4‑Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria
Gerasyuto, Aleksey I, Arnold, Michael A, Wang, Jiashi, Chen, Guangming, Zhang, Xiaoyan, Smith, Sean, Woll, Matthew G, Baird, John, Zhang, Nanjing, Almstead, Neil G, Narasimhan, Jana, Peddi, Srinivasa, Dumble, Melissa, Sheedy, Josephine, Weetall, Marla, Branstrom, Arthur A, Prasad, J. V. N, Karp, Gary M
Published in Journal of medicinal chemistry (24.05.2018)
Published in Journal of medicinal chemistry (24.05.2018)
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Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia
Branstrom, Arthur, Cao, Liangxian, Furia, Bansri, Trotta, Christopher, Santaguida, Marianne, Graci, Jason D, Colacino, Joseph M, Ray, Balmiki, Li, Wencheng, Sheedy, Josephine, Mollin, Anna, Yeh, Shirley, Kong, Ronald, Sheridan, Richard, Baird, John D, O'Keefe, Kylie, Spiegel, Robert, Goodwin, Elizabeth, Keating, Suzanne, Weetall, Marla
Published in Frontiers in oncology (09.02.2022)
Published in Frontiers in oncology (09.02.2022)
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Journal Article
Targeting of BMI-1 expression by the novel small molecule PTC596 in mantle cell lymphoma
Maeda, Aya, Nishida, Yuki, Weetall, Marla, Cao, Liangxian, Branstrom, Arthur, Ishizawa, Jo, Nii, Takenobu, Schober, Wendy D, Abe, Yoshiaki, Matsue, Kosei, Yoshimura, Mariko, Kimura, Shinya, Kojima, Kensuke
Published in Oncotarget (19.06.2018)
Published in Oncotarget (19.06.2018)
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4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis
Arnold, Michael A., Gerasyuto, Aleksey I., Wang, Jiashi, Du, Wu, Gorske, Yi Jin Kim, Arasu, Tamil, Baird, John, Almstead, Neil G., Narasimhan, Jana, Peddi, Srinivasa, Ginzburg, Olya, Lue, Stanley W., Hedrick, Jean, Sheedy, Josephine, Lagaud, Guy, Branstrom, Arthur A., Weetall, Marla, Prasad, J.V.N. Vara, Karp, Gary M.
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
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Journal Article
Correction to Discovery and Optimization of Indolyl-Containing 4‑Hydroxy-2-pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-Negative Bacteria
Gerasyuto, Aleksey I, Arnold, Michael A, Wang, Jiashi, Chen, Guangming, Zhang, Xiaoyan, Smith, Sean, Woll, Matthew G, Baird, John, Zhang, Nanjing, Almstead, Neil G, Narasimhan, Jana, Peddi, Srinivasa, Dumble, Melissa, Sheedy, Josephine, Weetall, Marla, Branstrom, Arthur A, Prasad, J. V. N, Karp, Gary M
Published in Journal of medicinal chemistry (25.10.2018)
Published in Journal of medicinal chemistry (25.10.2018)
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Journal Article
Genetic Basis for Activity Differences between Vancomycin and Glycolipid Derivatives of Vancomycin
Eggert, Ulrike S., Ruiz, Natividad, Falcone, Brian V., Branstrom, Arthur A., Goldman, Robert C., Silhavy, Thomas J., Kahne, Daniel
Published in Science (American Association for the Advancement of Science) (12.10.2001)
Published in Science (American Association for the Advancement of Science) (12.10.2001)
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Chlorobiphenyl-desleucyl-vancomycin inhibits the transglycosylation process required for peptidoglycan synthesis in bacteria in the absence of dipeptide binding
Goldman, Robert C, Baizman, Eugene R, Longley, Clifford B, Branstrom, Arthur A
Published in FEMS microbiology letters (15.02.2000)
Published in FEMS microbiology letters (15.02.2000)
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Structure of Francisella tularensis peptidyl-tRNA hydrolase
Clarke, Teresa E., Romanov, Vladimir, Lam, Robert, Gothe, Scott A., Peddi, Srinivasa R., Razumova, Ekaterina B., Lipman, Richard S. A., Branstrom, Arthur A., Chirgadze, Nickolay Y.
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.04.2011)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.04.2011)
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Antibacterial activity of synthetic analogues based on the disaccharide structure of moenomycin, an inhibitor of bacterial transglycosylase
Baizman, Eugene R, Branstrom, Arthur A, Longley, Clifford B, Allanson, Nigel, Sofia, Michael J, Gange, David, Goldman, Robert C
Published in Microbiology (Society for General Microbiology) (01.12.2000)
Published in Microbiology (Society for General Microbiology) (01.12.2000)
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Journal Article
In situ assay for identifying inhibitors of bacterial transglycosylase
Branstrom, Arthur A, Midha, Sunita, Goldman, Robert C
Published in FEMS microbiology letters (15.10.2000)
Published in FEMS microbiology letters (15.10.2000)
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Journal Article
Synthesis and Mode of Action of Hydrophobic Derivatives of the Glycopeptide Antibiotic Eremomycin and Des-(N-methyl-d-leucyl)eremomycin against Glycopeptide-Sensitive and -Resistant Bacteria
Printsevskaya, Svetlana S, Pavlov, Andrey Y, Olsufyeva, Evgenia N, Mirchink, Elena P, Isakova, Elena B, Reznikova, Marina I, Goldman, Robert C, Branstrom, Arthur A, Baizman, Eugene R, Longley, Clifford B, Sztaricskai, Ferenc, Batta, Gyula, Preobrazhenskaya, Maria N
Published in Journal of medicinal chemistry (14.03.2002)
Published in Journal of medicinal chemistry (14.03.2002)
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Journal Article
Chlorobiphenyl-desleucyl-vancomycin inhibits the transglycosylation process required for peptidoglycan synthesis in bacteria in the absence of dipeptide binding
Goldman, Robert C., Baizman, Eugene R., Longley, Clifford B., Branstrom, Arthur A.
Published in FEMS microbiology letters (01.02.2000)
Published in FEMS microbiology letters (01.02.2000)
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Chemical modifications of G418 (geneticin): Synthesis of novel readthrough aminoglycosides results in an improved in vitro safety window but no improvements in vivo
Baiazitov, Ramil Y., Friesen, Westley, Johnson, Briana, Mollin, Anna, Sheedy, Josephine, Sierra, Jairo, Weetall, Marla, Branstrom, Arthur, Welch, Ellen, Moon, Young-Choon
Published in Carbohydrate research (01.09.2020)
Published in Carbohydrate research (01.09.2020)
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