The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists
Rech, Jason C., Bhattacharya, Anindya, Branstetter, Bryan J., Love, Christopher J., Leenaerts, Joseph E., Cooymans, Ludwig P., Eckert, William A., Ao, Hong, Wang, Qi, Chaplan, Sandra R., Wickenden, Alan D., Lebsack, Alec D., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4- d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist
Maher, Michael P., Bhattacharya, Anindya, Ao, Hong, Swanson, Nadia, Wu, Nyan-Tsz, Freedman, Jamie, Kansagara, Mena, Scott, Brian, Li, Dong H., Eckert, William A., Liu, Yi, Sepassi, Kia, Rizzolio, Michele, Fitzgerald, Anne, Liu, Jing, Branstetter, Bryan J., Rech, Jason C., Lebsack, Alec D., Breitenbucher, J. Guy, Wickenden, Alan D., Chaplan, Sandra R.
Published in European journal of pharmacology (01.08.2011)
Published in European journal of pharmacology (01.08.2011)
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Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists
HAWRYLUK, Natalie A, MERIT, Jeffrey E, FREEDMAN, Jamie M, SCOTT, Brian P, WICKENDEN, Alan D, CHAPLAN, Sandra R, BREITENBUCHER, J. Guy, LEBSACK, Alec D, BRANSTETTER, Bryan J, HACK, Michael D, SWANSON, Nadia, HONG AO, MAHER, Michael P, BHATTACHARYA, Anindya, QI WANG
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Identification and synthesis of 2,7-diamino-thiazolo[5,4- d]pyrimidine derivatives as TRPV1 antagonists
Lebsack, Alec D., Branstetter, Bryan J., Hack, Michael D., Xiao, Wei, Peterson, Matthew L., Nasser, Nadia, Maher, Michael P., Ao, Hong, Bhattacharya, Anindya, Kansagara, Mena, Scott, Brian P., Luo, Lin, Rynberg, Raymond, Rizzolio, Michele, Chaplan, Sandra R., Wickenden, Alan D., Guy Breitenbucher, J.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties
LEBSACK, Alec D, RECH, Jason C, HONG AO, MAHER, Michael P, HERRMANN, Michelle, FREEDMAN, Jamie, SCOTT, Brian P, LIN LUO, BHATTACHARYA, Anindya, QI WANG, CHAPLAN, Sandra R, WICKENDEN, Alan D, BRANSTETTER, Bryan J, BREITENBUCHER, J. Guy, HAWRYLUK, Natalie A, MERIT, Jeffrey E, ALLISON, Brett, RYNBERG, Raymond, BUMA, Johnathan, RIZZOLIO, Michele, SWANSON, Nadia
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties
Dyck, Brian, Branstetter, Bryan, Gharbaoui, Tawfik, Hudson, Andrew R, Breitenbucher, J. Guy, Gomez, Laurent, Botrous, Iriny, Marrone, Tami, Barido, Richard, Allerston, Charles K, Cedervall, E. Peder, Xu, Rui, Sridhar, Vandana, Barker, Ryan, Aertgeerts, Kathleen, Schmelzer, Kara, Neul, David, Lee, Dong, Massari, Mark Eben, Andersen, Carsten B, Sebring, Kristen, Zhou, Xianbo, Petroski, Robert, Limberis, James, Augustin, Martin, Chun, Lawrence E, Edwards, Thomas E, Peters, Marco, Tabatabaei, Ali
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Journal Article
The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)p y rimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists
Rech, Jason C, Bhattacharya, Anindya, Branstetter, Bryan J, Love, Christopher J, Leenaerts, Joseph E, Cooymans, Ludwig P, Eckert, William A, Ao, Hong, Wang, Qi, Chaplan, Sandra R, Wickenden, Alan D, Lebsack, Alec D, Breitenbucher, JGuy
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Acid-Catalyzed Reactions of Aromatic Aldehydes with Ethyl Diazoacetate: An Investigation on the Synthesis of 3-Hydroxy-2-arylacrylic Acid Ethyl Esters
Dudley, Matthew E, Morshed, Md. Monzur, Brennan, Courtney L, Islam, M. Shahidul, Ahmad, M. Syarhabil, Atuu, Mary-Rose, Branstetter, Bryan, Hossain, M. Mahmun
Published in Journal of organic chemistry (29.10.2004)
Published in Journal of organic chemistry (29.10.2004)
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SUBSTITUTED THIOPHENE- AND FURAN-FUSED AZOLOPYRIMIDINE-5-(6H)-ONE COMPOUNDS
BREITENBUCHER JAMES, PETERS MARCO, VICKERS TROY, DYCK BRIAN, HUDSON ANDREW RICHARD, GOMEZ LAURENT, BRANSTETTER BRYAN, MARRONE TAMI JO
Year of Publication 08.06.2015
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Year of Publication 08.06.2015
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SUBSTITUTED PYRIDINE AZOLOPYRIMIDINE-5-(6H)-ONE COMPOUNDS
PETERS MARCO, ALLAN AMY, DYCK BRIAN, GOMEZ LAURENT, BRANSTETTER BRYAN, WEINHOUSE MICHAEL I, MARRONE TAMI JO
Year of Publication 08.06.2015
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Year of Publication 08.06.2015
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Discovery and synthesis of 6,7,8,9-tetrahydro-5 H-pyrimido-[4,5- d]azepines as novel TRPV1 antagonists
Hawryluk, Natalie A., Merit, Jeffrey E., Lebsack, Alec D., Branstetter, Bryan J., Hack, Michael D., Swanson, Nadia, Ao, Hong, Maher, Michael P., Bhattacharya, Anindya, Wang, Qi, Freedman, Jamie M., Scott, Brian P., Wickenden, Alan D., Chaplan, Sandra R., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5 H-pyrimido[4,5- d]azepines as TRPV1 antagonists with improved properties
Lebsack, Alec D., Rech, Jason C., Branstetter, Bryan J., Hawryluk, Natalie A., Merit, Jeffrey E., Allison, Brett, Rynberg, Raymond, Buma, Johnathan, Rizzolio, Michele, Swanson, Nadia, Ao, Hong, Maher, Michael P., Herrmann, Michelle, Freedman, Jamie, Scott, Brian P., Luo, Lin, Bhattacharya, Anindya, Wang, Qi, Chaplan, Sandra R., Wickenden, Alan D., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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QUINOLINE OR ISOQUINOLINE SUBSTITUTED P2X7 ANTAGONISTS
GLEASON ELIZABETH ANN, VENABLE JENNIFER DIANE, COOYMANS LUDWIG PAUL, LEENAERTS JOSEPH ELISABETH, LOVE CHRISTOPHER JOHN, SMITH DEBORAH MARGARET, RECH JASON CHRISTOPHER, BREITENBUCHER JAMES GUY, BRANSTETTER BRYAN JAMES, WIENER DANIELLE, LEBSACK ALEC DONALD
Year of Publication 07.02.2011
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Year of Publication 07.02.2011
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Year of Publication 16.02.2022
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BRANSTETTER, Bryan, PETERS, Marco, MARRONE, Tami, Jo, WEINHOUSE, Michael, I, DYCK, Brian, ALLAN, Amy, GOMEZ, Laurent
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Year of Publication 10.01.2022
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PHARMACEUTICAL COMPOSITIONS OF 6H-PYRIDO[3,2-E][1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-5-ONE AND [1,2,4]TRIAZOLO[1,5-C]PTERIDIN-5(6H)-ONE DERIVATIVES AS PDE1 INHIBITORS FOR TREATING E.G. NEUROLOGICAL DISORDERS
BRANSTETTER, Bryan, PETERS, Marco, MARRONE, Tami, Jo, WEINHOUSE, Michael, I, DYCK, Brian, ALLAN, Amy, GOMEZ, Laurent
Year of Publication 13.10.2021
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Year of Publication 13.10.2021
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Reclaiming storage resources
Hiregoudar, Mahesh S, Krishnamurthy, Pradeep, Shantharam, Srinivasa, Pichai, Raghavan, Desai, Asit, Aithal, Prasanna, Jangam, Prasad Rao, Branstetter, Bryan, Pasalkar, Rohan
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Year of Publication 24.05.2022
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SUBSTITUTED METHYL PYRAZOLOPYRIMIDINONE AND METHYL IMIDAZOPYRAZINONE COMPOUNDS AS PDE1 INHIBITORS
Weinhouse, Michael, Botrous, Iriny, Bookser, Brett, Branstetter, Bryan, Dyck, Brian
Year of Publication 13.06.2019
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Year of Publication 13.06.2019
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