The shieldin complex mediates 53BP1-dependent DNA repair
Noordermeer, Sylvie M., Adam, Salomé, Setiaputra, Dheva, Barazas, Marco, Pettitt, Stephen J., Ling, Alexanda K., Olivieri, Michele, Álvarez-Quilón, Alejandro, Moatti, Nathalie, Zimmermann, Michal, Annunziato, Stefano, Krastev, Dragomir B., Song, Feifei, Brandsma, Inger, Frankum, Jessica, Brough, Rachel, Sherker, Alana, Landry, Sébastien, Szilard, Rachel K., Munro, Meagan M., McEwan, Andrea, Goullet de Rugy, Théo, Lin, Zhen-Yuan, Hart, Traver, Moffat, Jason, Gingras, Anne-Claude, Martin, Alberto, van Attikum, Haico, Jonkers, Jos, Lord, Christopher J., Rottenberg, Sven, Durocher, Daniel
Published in Nature (London) (01.08.2018)
Published in Nature (London) (01.08.2018)
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Journal Article
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
Pettitt, Stephen J., Krastev, Dragomir B., Brandsma, Inger, Dréan, Amy, Song, Feifei, Aleksandrov, Radoslav, Harrell, Maria I., Menon, Malini, Brough, Rachel, Campbell, James, Frankum, Jessica, Ranes, Michael, Pemberton, Helen N., Rafiq, Rumana, Fenwick, Kerry, Swain, Amanda, Guettler, Sebastian, Lee, Jung-Min, Swisher, Elizabeth M., Stoynov, Stoyno, Yusa, Kosuke, Ashworth, Alan, Lord, Christopher J.
Published in Nature communications (10.05.2018)
Published in Nature communications (10.05.2018)
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Journal Article
Directing the use of DDR kinase inhibitors in cancer treatment
Brandsma, Inger, Fleuren, Emmy D G, Williamson, Chris T, Lord, Christopher J
Published in Expert opinion on investigational drugs (02.12.2017)
Published in Expert opinion on investigational drugs (02.12.2017)
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Journal Article
Modeling Therapy Resistance in BRCA1/2 -Mutant Cancers
Dréan, Amy, Williamson, Chris T, Brough, Rachel, Brandsma, Inger, Menon, Malini, Konde, Asha, Garcia-Murillas, Isaac, Pemberton, Helen N, Frankum, Jessica, Rafiq, Rumana, Badham, Nicholas, Campbell, James, Gulati, Aditi, Turner, Nicholas C, Pettitt, Stephen J, Ashworth, Alan, Lord, Christopher J
Published in Molecular cancer therapeutics (01.09.2017)
Published in Molecular cancer therapeutics (01.09.2017)
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Journal Article
REV7 counteracts DNA double-strand break resection and affects PARP inhibition
Xu, Guotai, Chapman, J. Ross, Brandsma, Inger, Yuan, Jingsong, Mistrik, Martin, Bouwman, Peter, Bartkova, Jirina, Gogola, Ewa, Warmerdam, Daniël, Barazas, Marco, Jaspers, Janneke E., Watanabe, Kenji, Pieterse, Mark, Kersbergen, Ariena, Sol, Wendy, Celie, Patrick H. N., Schouten, Philip C., van den Broek, Bram, Salman, Ahmed, Nieuwland, Marja, de Rink, Iris, de Ronde, Jorma, Jalink, Kees, Boulton, Simon J., Chen, Junjie, van Gent, Dik C., Bartek, Jiri, Jonkers, Jos, Borst, Piet, Rottenberg, Sven
Published in Nature (London) (28.05.2015)
Published in Nature (London) (28.05.2015)
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Journal Article
HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis
Brandsma, Inger, Sato, Koichi, van Rossum-Fikkert, Sari E., van Vliet, Nicole, Sleddens, Esther, Reuter, Marcel, Odijk, Hanny, van den Tempel, Nathalie, Dekkers, Dick H.W., Bezstarosti, Karel, Demmers, Jeroen A.A., Maas, Alex, Lebbink, Joyce, Wyman, Claire, Essers, Jeroen, van Gent, Dik C., Baarends, Willy M., Knipscheer, Puck, Kanaar, Roland, Zelensky, Alex N.
Published in Cell reports (Cambridge) (25.06.2019)
Published in Cell reports (Cambridge) (25.06.2019)
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Journal Article
On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation
van den Tempel, Nathalie, Zelensky, Alex N, Odijk, Hanny, Laffeber, Charlie, Schmidt, Christine K, Brandsma, Inger, Demmers, Jeroen, Krawczyk, Przemek M, Kanaar, Roland
Published in Cancers (15.01.2019)
Published in Cancers (15.01.2019)
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Journal Article
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells
Nikkilä, Jenni, Kumar, Rahul, Campbell, James, Brandsma, Inger, Pemberton, Helen N, Wallberg, Fredrik, Nagy, Kinga, Scheer, Ildikó, Vertessy, Beata G, Serebrenik, Artur A, Monni, Valentina, Harris, Reuben S, Pettitt, Stephen J, Ashworth, Alan, Lord, Christopher J
Published in British journal of cancer (23.05.2017)
Published in British journal of cancer (23.05.2017)
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Journal Article
Attenuated XPC expression is not associated with impaired DNA repair in bladder cancer
Naipal, Kishan A T, Raams, Anja, Bruens, Serena T, Brandsma, Inger, Verkaik, Nicole S, Jaspers, Nicolaas G J, Hoeijmakers, Jan H J, van Leenders, Geert J L H, Pothof, Joris, Kanaar, Roland, Boormans, Joost, van Gent, Dik C
Published in PloS one (30.04.2015)
Published in PloS one (30.04.2015)
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Journal Article
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1
Drost, Rinske, Dhillon, Kiranjit K., van der Gulden, Hanneke, van der Heijden, Ingrid, Brandsma, Inger, Cruz, Cristina, Chondronasiou, Dafni, Castroviejo-Bermejo, Marta, Boon, Ute, Schut, Eva, van der Burg, Eline, Wientjens, Ellen, Pieterse, Mark, Klijn, Christiaan, Klarenbeek, Sjoerd, Loayza-Puch, Fabricio, Elkon, Ran, van Deemter, Liesbeth, Rottenberg, Sven, van de Ven, Marieke, Dekkers, Dick H.W., Demmers, Jeroen A.A., van Gent, Dik C., Agami, Reuven, Balmaña, Judith, Serra, Violeta, Taniguchi, Toshiyasu, Bouwman, Peter, Jonkers, Jos
Published in The Journal of clinical investigation (01.08.2016)
Published in The Journal of clinical investigation (01.08.2016)
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Journal Article
Genotoxicity evaluation of 2,4-D, dicamba and glyphosate alone or in combination with cell reporter assays for DNA damage, oxidative stress and unfolded protein response
Mesnage, Robin, Brandsma, Inger, Moelijker, Nynke, Zhang, Gaonan, Antoniou, Michael N.
Published in Food and chemical toxicology (01.11.2021)
Published in Food and chemical toxicology (01.11.2021)
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Journal Article
A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 2 b: Reactive cobalt substances induce oxidative stress in ToxTracker and activate hypoxia target genes
Derr, Remco, Moelijker, Nynke, Hendriks, Giel, Brandsma, Inger
Published in Regulatory toxicology and pharmacology (01.03.2022)
Published in Regulatory toxicology and pharmacology (01.03.2022)
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Journal Article
Genotoxicity assessment of potentially mutagenic nucleoside analogues using ToxTracker
Brandsma, Inger, Derr, Remco, Zhang, Gaonan, Moelijker, Nynke, Hendriks, Giel, Østerlund, Torben
Published in Toxicology letters (01.06.2022)
Published in Toxicology letters (01.06.2022)
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Journal Article
Comparative Toxicogenomics of Glyphosate and Roundup Herbicides by Mammalian Stem Cell-Based Genotoxicity Assays and Molecular Profiling in Sprague-Dawley Rats
Mesnage, Robin, Ibragim, Mariam, Mandrioli, Daniele, Falcioni, Laura, Tibaldi, Eva, Belpoggi, Fiorella, Brandsma, Inger, Bourne, Emma, Savage, Emanuel, Mein, Charles A, Antoniou, Michael N
Published in Toxicological sciences (28.02.2022)
Published in Toxicological sciences (28.02.2022)
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Journal Article
The surfactant co-formulant POEA in the glyphosate-based herbicide RangerPro but not glyphosate alone causes necrosis in Caco-2 and HepG2 human cell lines and ER stress in the ToxTracker assay
Mesnage, Robin, Ferguson, Scarlett, Brandsma, Inger, Moelijker, Nynke, Zhang, Gaonan, Mazzacuva, Francesca, Caldwell, Anna, Halket, John, Antoniou, Michael N.
Published in Food and chemical toxicology (01.10.2022)
Published in Food and chemical toxicology (01.10.2022)
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Journal Article