DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis
Mowbray, Charles E, Braillard, Stéphanie, Glossop, Paul A, Whitlock, Gavin A, Jacobs, Robert T, Speake, Jason, Pandi, Bharathi, Nare, Bakela, Maes, Louis, Yardley, Vanessa, Freund, Yvonne, Wall, Richard J, Carvalho, Sandra, Bello, Davide, Van den Kerkhof, Magali, Caljon, Guy, Gilbert, Ian H, Corpas-Lopez, Victoriano, Lukac, Iva, Patterson, Stephen, Zuccotto, Fabio, Wyllie, Susan
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
Get full text
Journal Article
Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity
Mowbray, Charles E, Braillard, Stéphanie, Speed, William, Glossop, Paul A, Whitlock, Gavin A, Gibson, Karl R, Mills, James E. J, Brown, Alan D, Gardner, J. Mark F, Cao, Yafeng, Hua, Wen, Morgans, Garreth L, Feijens, Pim-Bart, Matheeussen, An, Maes, Louis J
Published in Journal of medicinal chemistry (24.12.2015)
Published in Journal of medicinal chemistry (24.12.2015)
Get full text
Journal Article
Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis
Wijnant, Gert-Jan, Croft, Simon L, de la Flor, Raul, Alavijeh, Mo, Yardley, Vanessa, Braillard, Stéphanie, Mowbray, Charles, Van Bocxlaer, Katrien
Published in Antimicrobial agents and chemotherapy (01.09.2019)
Published in Antimicrobial agents and chemotherapy (01.09.2019)
Get full text
Journal Article
Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis
Van Bocxlaer, Katrien, Caridha, Diana, Black, Chad, Vesely, Brian, Leed, Susan, Sciotti, Richard J., Wijnant, Gert-Jan, Yardley, Vanessa, Braillard, Stéphanie, Mowbray, Charles E., Ioset, Jean-Robert, Croft, Simon L.
Published in International journal for parasitology -- drugs and drug resistance (01.12.2019)
Published in International journal for parasitology -- drugs and drug resistance (01.12.2019)
Get full text
Journal Article
Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series
Van den Kerkhof, Magali, Leprohon, Philippe, Mabille, Dorien, Hendrickx, Sarah, Tulloch, Lindsay B, Wall, Richard J, Wyllie, Susan, Chatelain, Eric, Mowbray, Charles E, Braillard, Stéphanie, Ouellette, Marc, Maes, Louis, Caljon, Guy
Published in Microorganisms (Basel) (29.06.2021)
Published in Microorganisms (Basel) (29.06.2021)
Get full text
Journal Article
Development and validation of LC–MS/MS method for determination of DNDI-VL-2098 in mouse, rat, dog and hamster blood
Patel, Bhavesh D, Uppal, Ritika, Pulakundam, Nageswararao, Patel, Jignesh P, Ramanathan, Vikram, Ameta, Rakshit, Launay, Delphine, Braillard, Stéphanie
Published in Bioanalysis (01.08.2019)
Published in Bioanalysis (01.08.2019)
Get full text
Journal Article
Enantiomers of nifurtimox do not exhibit stereoselective anti-Trypanosoma cruzi activity, toxicity, or pharmacokinetic properties
Moraes, Carolina B, White, Karen L, Braillard, Stéphanie, Perez, Catherine, Goo, Junghyun, Gaspar, Luis, Shackleford, David M, Cordeiro-da-Silva, Anabela, Thompson, R C Andrew, Freitas-Junior, Lucio, Charman, Susan A, Chatelain, Eric
Published in Antimicrobial agents and chemotherapy (01.06.2015)
Published in Antimicrobial agents and chemotherapy (01.06.2015)
Get full text
Journal Article
Inhibitors of bacterial virulence identified in a surrogate host model
Benghezal, Mohammed, Adam, Eric, Lucas, Aurore, Burn, Christine, Orchard, Michael G, Deuschel, Christine, Valentino, Emilio, Braillard, Stéphanie, Paccaud, Jean-Pierre, Cosson, Pierre
Published in Cellular microbiology (01.05.2007)
Published in Cellular microbiology (01.05.2007)
Get full text
Journal Article
Development of (6R)-2-Nitro-644-(trifluoromethoxy)phenoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis
Thompson, Andrew M., O'Connor, Patrick D., Marshall, Andrew J., Blaser, Adrian, Yardley, Vanessa, Maes, Louis, Gupta, Suman, Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Wan, Baojie, Franzblau, Scott G., Ma, Zhenkun, Cooper, Christopher B., Denny, William A.
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
Get full text
Journal Article
7‑Substituted 2‑Nitro-5,6-dihydroimidazo[2,1‑b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis
Thompson, Andrew M, O’Connor, Patrick D, Marshall, Andrew J, Yardley, Vanessa, Maes, Louis, Gupta, Suman, Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Franzblau, Scott G, Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Cooper, Christopher B, Denny, William A
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
Get full text
Journal Article
Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis
Thompson, Andrew M, O'Connor, Patrick D, Marshall, Andrew J, Blaser, Adrian, Yardley, Vanessa, Maes, Louis, Gupta, Suman, Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Wan, Baojie, Franzblau, Scott G, Ma, Zhenkun, Cooper, Christopher B, Denny, William A
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
Get full text
Journal Article
Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal
Thompson, Andrew M., O’Connor, Patrick D., Marshall, Andrew J., Yardley, Vanessa, Maes, Louis, Gupta, Suman, Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Wan, Baojie, Franzblau, Scott G., Ma, Zhenkun, Cooper, Christopher B., Denny, William A.
Published in European journal of medicinal chemistry (01.01.2021)
Published in European journal of medicinal chemistry (01.01.2021)
Get full text
Journal Article
Short-course combination treatment for experimental chronic Chagas disease
González, Silvia, Wall, Richard J, Thomas, John, Braillard, Stephanie, Brunori, Gino, Camino Díaz, Isabel, Cantizani, Juan, Carvalho, Sandra, Castañeda Casado, Pablo, Chatelain, Eric, Cotillo, Ignacio, Fiandor, Jose M, Francisco, Amanda Fortes, Grimsditch, David, Keenan, Martine, Kelly, John M, Kessler, Albane, Luise, Chiara, Lyon, Jon J, MacLean, Lorna, Marco, Maria, Martin, J Julio, Martinez Martinez, Maria S, Paterson, Christy, Read, Kevin D, Santos-Villarejo, Angel, Zuccotto, Fabio, Wyllie, Susan, Miles, Tim J, De Rycker, Manu
Published in Science translational medicine (13.12.2023)
Published in Science translational medicine (13.12.2023)
Get more information
Journal Article
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides
Thompson, Andrew M., Marshall, Andrew J., Maes, Louis, Yarlett, Nigel, Bacchi, Cyrus J., Gaukel, Eric, Wring, Stephen A., Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Mowbray, Charles E., Denny, William A.
Published in Bioorganic & medicinal chemistry letters (15.01.2018)
Published in Bioorganic & medicinal chemistry letters (15.01.2018)
Get full text
Journal Article
Novel Linker Variants of Antileishmanial/Antitubercular 7‑Substituted 2‑Nitroimidazooxazines Offer Enhanced Solubility
Thompson, Andrew M, O’Connor, Patrick D, Yardley, Vanessa, Maes, Louis, Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Wan, Baojie, Franzblau, Scott G, Ma, Zhenkun, Cooper, Christopher B, Denny, William A
Published in ACS medicinal chemistry letters (11.02.2021)
Published in ACS medicinal chemistry letters (11.02.2021)
Get full text
Journal Article
Development of (6R)‑2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro‑5H‑imidazo[2,1‑b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis
Thompson, Andrew M, O’Connor, Patrick D, Marshall, Andrew J, Blaser, Adrian, Yardley, Vanessa, Maes, Louis, Gupta, Suman, Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Wan, Baojie, Franzblau, Scott G, Ma, Zhenkun, Cooper, Christopher B, Denny, William A
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
Get full text
Journal Article
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc 1
Braillard, Stéphanie, Keenan, Martine, Breese, Karen J, Heppell, Jacob, Abbott, Michael, Islam, Rafiqul, Shackleford, David M, Katneni, Kasiram, Crighton, Elly, Chen, Gong, Patil, Rahul, Lee, Given, White, Karen L, Carvalho, Sandra, Wall, Richard J, Chemi, Giulia, Zuccotto, Fabio, González, Silvia, Marco, Maria, Deakyne, Julianna, Standing, David, Brunori, Gino, Lyon, Jonathan J, Castañeda-Casado, Pablo, Camino, Isabel, Martinez Martinez, Maria S, Zulfiqar, Bilal, Avery, Vicky M, Feijens, Pim-Bart, Van Pelt, Natascha, Matheeussen, An, Hendrickx, Sarah, Maes, Louis, Caljon, Guy, Yardley, Vanessa, Wyllie, Susan, Charman, Susan A, Chatelain, Eric
Published in Science translational medicine (13.12.2023)
Published in Science translational medicine (13.12.2023)
Get more information
Journal Article