A first-in-human phase I dose-escalation, pharmacokinetic, and pharmacodynamic evaluation of intravenous LY2090314, a glycogen synthase kinase 3 inhibitor, administered in combination with pemetrexed and carboplatin
Gray, Jhanelle E., Infante, Jeffrey R., Brail, Les H., Simon, George R., Cooksey, Jennifer F., Jones, Suzanne F., Farrington, Daphne L., Yeo, Adeline, Jackson, Kimberley A., Chow, Kay H., Zamek-Gliszczynski, Maciej J., Burris, Howard A.
Published in Investigational new drugs (01.12.2015)
Published in Investigational new drugs (01.12.2015)
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A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours
Tolcher, Anthony, Goldman, Jonathan, Patnaik, Amita, Papadopoulos, Kyriakos P, Westwood, Paul, Kelly, Claudia S, Bumgardner, William, Sams, Lillian, Geeganage, Sandaruwan, Wang, Tao, Capen, Andrew R, Huang, Jianping, Joseph, Sajan, Miller, Joel, Benhadji, Karim A, Brail, Les H, Rosen, Lee S
Published in European journal of cancer (1990) (01.03.2014)
Published in European journal of cancer (1990) (01.03.2014)
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A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours
Hollebecque, Antoine, Houédé, Nadine, Cohen, Ezra E.W, Massard, Christophe, Italiano, Antoine, Westwood, Paul, Bumgardner, William, Miller, Joel, Brail, Les H, Benhadji, Karim A, Soria, Jean-Charles
Published in European journal of cancer (1990) (01.03.2014)
Published in European journal of cancer (1990) (01.03.2014)
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FRESCO: A phase 2, randomized study of duvelisib plus rituximab vs R-CHOP in patients with relapsed/refractory follicular lymphoma who have progressed within 24 months of receiving an alkylator-based chemotherapy regimen
Fowler, Nathan Hale, Pearlberg, Joseph, Brail, Les H., Shi, Weiliang, Jiang, Liewen, Condon, Carrie, Rummel, Mathias J.
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Initial results from first-in-human study of IPI-549, a tumor macrophage-targeting agent, combined with nivolumab in advanced solid tumors
Sullivan, Ryan J., Hong, David S., Tolcher, Anthony W., Patnaik, Amita, Shapiro, Geoffrey, Chmielowski, Bartosz, Ribas, Antoni, Brail, Les H., Roberts, Jennifer, Lee, Lucy, O'Connell, Brenda, Kutok, Jeffrey Lorne, Mahabhashyam, Suresh, Dansky Ullmann, Claudio, Postow, Michael A., Wolchok, Jedd D.
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Abstract 5006: Comprehensive gene expression analysis of the tumor microenvironment in patients with advanced cancer treated with a personalized neoantigen vaccine, NEO-PV-01, in combination with anti-PD1
Bushway, Meghan E., Ting, Ying Sonia, Besada, Rana H., Sciuto, Tracey E., Prabhakara, Jasmina, Scherer, Julian, Balogh, Kristen N., Lamb, April, Kaplan, Jennifer A., Cleary, Lisa D., Moles, Melissa A., Church, Sarah E., Ren, Yuqi, Ren, Xing, Gaynor, Richard B., Goldstein, Matthew J., Brail, Les H., Greshock, Joel, Srinivasan, Lakshmi
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 942: The personalized vaccine, NEO-PV-01 with anti-PD1, induces neoantigen-specific de novo immune responses in patients with advanced metastatic melanoma: Association with clinical outcomes
Hu-Lieskovan, Siwen, Ott, Patrick A., Naing, Aung, Besada, Rana H., Gates, Samantha J., Kohler, Victoria R., Curran, Riley R., Bushway, Meghan E., Scherer, Julian, Balogh, Kristen N., Sciuto, Tracey E., Ting, Ying S., Rooney, Michael S., Harjanto, Dewi, Huang, Zhengping, Huang, Yuting, Ware, Yvonne, Lamb, April, Cleary, Lisa D., Moles, Melissa A., Gaynor, Richard B., Goldstein, Matthew J., Brail, Les H., Greshock, Joel, Srinivasan, Lakshmi
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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IPI-549-01-A phase 1/1b first in human study of IPI-549, a PI3K-γ inhibitor, as monotherapy and in combination with pembrolizumab in subjects with advanced solid tumors
Tolcher, Anthony W., Hong, David S., Sullivan, Ryan J., Mier, James Walter, Shapiro, Geoffrey, Pearlberg, Joseph, Brail, Les H., Kharidia, Jahnavi, Han, Lixin, Dansky Ullmann, Claudio, Stern, Howard Marvin, Wolchok, Jedd D.
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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