An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma
Bai, Yujing, Xu, Jing, Brahimi, Fouad, Zhuo, Yehong, Sarunic, Marinko V, Saragovi, H Uri
Published in Investigative ophthalmology & visual science (01.09.2010)
Published in Investigative ophthalmology & visual science (01.09.2010)
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Journal Article
GD2 and GD3 gangliosides as diagnostic biomarkers for all stages and subtypes of epithelial ovarian cancer
Galan, Alba, Papaluca, Arturo, Nejatie, Ali, Matanes, Emad, Brahimi, Fouad, Tong, Wenyong, Hachim, Ibrahim Yaseen, Yasmeen, Amber, Carmona, Euridice, Klein, Kathleen Oros, Billes, Sonja, Dawod, Ahmed E, Gawande, Prasad, Jeter, Anna Milik, Mes-Masson, Anne-Marie, Greenwood, Celia M T, Gotlieb, Walter H, Saragovi, H Uri
Published in Frontiers in oncology (14.04.2023)
Published in Frontiers in oncology (14.04.2023)
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Journal Article
Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation
Farnós, Omar, Venereo-Sánchez, Alina, Xu, Xingge, Chan, Cindy, Dash, Shantoshini, Chaabane, Hanan, Sauvageau, Janelle, Brahimi, Fouad, Saragovi, Uri, Leclerc, Denis, Kamen, Amine A
Published in Vaccines (Basel) (04.11.2020)
Published in Vaccines (Basel) (04.11.2020)
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Journal Article
Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors
Brahimi, Fouad, Ko, Eunhwa, Malakhov, Andrey, Burgess, Kevin, Saragovi, H Uri
Published in PloS one (06.03.2014)
Published in PloS one (06.03.2014)
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Journal Article
The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS
Brahimi, Fouad, Maira, Mario, Barcelona, Pablo F, Galan, Alba, Aboulkassim, Tahar, Teske, Katrina, Rogers, Mary-Louise, Bertram, Lisa, Wang, Jing, Yousefi, Masoud, Rush, Robert, Fabian, Marc, Cashman, Neil, Saragovi, H Uri
Published in PloS one (03.10.2016)
Published in PloS one (03.10.2016)
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Journal Article
The Combi-Targeting Concept: Synthesis of Stable Nitrosoureas Designed to Inhibit the Epidermal Growth Factor Receptor (EGFR)
Domarkas, Juozas, Dudouit, Fabienne, Williams, Christopher, Qiyu, Qiu, Banerjee, Ranjita, Brahimi, Fouad, Jean-Claude, Bertrand Jacques
Published in Journal of medicinal chemistry (15.06.2006)
Published in Journal of medicinal chemistry (15.06.2006)
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Journal Article
Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands
Brahimi, Fouad, Galan, Alba, Jmaeff, Sean, Barcelona, Pablo F., De Jay, Nicolas, Dejgaard, Kurt, Young, Jason C., Kleinman, Claudia L., Thomas, David Y., Saragovi, H. Uri
Published in iScience (25.09.2020)
Published in iScience (25.09.2020)
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Journal Article
The Combi-Targeting Concept: In vitro and In vivo Fragmentation of a Stable Combi-Nitrosourea Engineered to Interact with the Epidermal Growth Factor Receptor while Remaining DNA Reactive
Qiu, Qiyu, Domarkas, Juozas, Banerjee, Ranjita, Merayo, Nuria, Brahimi, Fouad, McNamee, James P, Gibbs, Bernard F, Jean-Claude, Bertrand J
Published in Clinical cancer research (01.01.2007)
Published in Clinical cancer research (01.01.2007)
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Journal Article
GD2 and GD3 tumor gangliosides as diagnostic markers for all subtypes and stages of ovarian cancer (OC) in liquid biopsies (1310)
Jeter, Anna, Galan, Alba, Papaluca, Arturo, Nejatie, Ali, Matanes, Emad, Fouad, Brahimi, Gawande, Prasad, Greenwood, Celia, Gotlieb, Walter, Saragovi, H. Uri
Published in Gynecologic oncology (01.09.2023)
Published in Gynecologic oncology (01.09.2023)
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Journal Article
Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor
Brahimi, Fouad, Galan, Alba, Siegel, Sairey, Szobota, Stephanie, Sarunic, Marinko V., Foster, Alan C., Saragovi, H. Uri
Published in Molecular pharmacology (01.11.2021)
Published in Molecular pharmacology (01.11.2021)
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Journal Article
GD2 and GD3 gangliosides as diagnostic biomarkers for all stages and subtypes of ovarian cancer
Jeter, Anna, Galan, Alba, Papaluca, Arturo, Nejatie, Ali, Matanes, Emad, Brahimi, Fouad, Yasmeen, Amber, Carmona, Euridice, Klein, Kathleen Oros, Billes, Sonja, Dawod, Ahmed E., Gawande, Prasad, Mes-Masson, Anne-Marie, Greenwood, Celia, Gotlieb, Walter H., Saragovi, H. Uri
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
Vaccination with Tumor-Ganglioside Glycomimetics Activates a Selective Immunity that Affords Cancer Therapy
Tong, Wenyong, Maira, Mario, Roychoudhury, Rajarshi, Galan, Alba, Brahimi, Fouad, Gilbert, Michel, Cunningham, Anna-Maria, Josephy, Sylvia, Pirvulescu, Iulia, Moffett, Serge, Saragovi, H Uri
Published in Cell chemical biology (18.07.2019)
Published in Cell chemical biology (18.07.2019)
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Journal Article
A Combinatorial Method for Solution-Phase Synthesis of Labeled Bivalent β-Turn Mimics
Angell, Yu, Chen, Dianjun, Brahimi, Fouad, Saragovi, H. Uri, Burgess, Kevin
Published in Journal of the American Chemical Society (16.01.2008)
Published in Journal of the American Chemical Society (16.01.2008)
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Journal Article
Bivalent Diketopiperazine-Based Tropomysin Receptor Kinase C (TrkC) Antagonists
Liu, Jing, Brahimi, Fouad, Saragovi, H. Uri, Burgess, Kevin
Published in Journal of medicinal chemistry (08.07.2010)
Published in Journal of medicinal chemistry (08.07.2010)
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Journal Article
Ligand-dependent TrkA activity in brain differentially affects spatial learning and long-term memory
Aboulkassim, Tahar, Tong, Xin-Kang, Tse, Yiu Chung, Wong, Tak-Pan, Woo, Sang B, Neet, Kenneth E, Brahimi, Fouad, Hamel, Edith, Saragovi, H Uri
Published in Molecular pharmacology (01.09.2011)
Published in Molecular pharmacology (01.09.2011)
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Journal Article
Bivalent Peptidomimetic Ligands of TrkC Are Biased Agonists and Selectively Induce Neuritogenesis or Potentiate Neurotrophin-3 Trophic Signals
Chen, Dianjun, Brahimi, Fouad, Angell, Yu, Li, Yu-Chin, Moscowicz, Jennifer, Saragovi, H. Uri, Burgess, Kevin
Published in ACS chemical biology (18.09.2009)
Published in ACS chemical biology (18.09.2009)
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Journal Article
Novel Nitrogen Mustard-Armed Combi-Molecules for the Selective Targeting of Epidermal Growth Factor Receptor Overexperessing Solid Tumors: Discovery of an Unusual Structure−Activity Relationship
Rachid, Zakaria, Brahimi, Fouad, Qiu, Qiyu, Williams, Christopher, Hartley, Janet M, Hartley, John A, Jean-Claude, Bertrand J
Published in Journal of medicinal chemistry (31.05.2007)
Published in Journal of medicinal chemistry (31.05.2007)
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Journal Article
A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist
Brahimi, Fouad, Liu, Jing, Malakhov, Andrey, Chowdhury, Shafinaz, Purisima, Enrico O., Ivanisevic, Ljubica, Caron, Antoine, Burgess, Kevin, Saragovi, H. Uri
Published in Biochimica et biophysica acta (01.09.2010)
Published in Biochimica et biophysica acta (01.09.2010)
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Journal Article
A bioanalytical investigation on the exquisitely strong in vitro potency of the EGFR–DNA targeting type II combi-molecule ZR2003 and its mitigated in vivo antitumour activity
Golabi, Nahid, Brahimi, Fouad, Huang, Ying, Rachid, Zakaria, Qiu, Qiyu, Larroque-Lombard, Anne-Laure, Jean-Claude, Bertrand J.
Published in Journal of pharmaceutical and biomedical analysis (01.11.2011)
Published in Journal of pharmaceutical and biomedical analysis (01.11.2011)
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