Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors
Waibel, Michaela, Solomon, Vanessa S., Knight, Deborah A., Ralli, Rachael A., Kim, Sang-Kyu, Banks, Kellie-Marie, Vidacs, Eva, Virely, Clemence, Sia, Keith C.S., Bracken, Lauryn S., Collins-Underwood, Racquel, Drenberg, Christina, Ramsey, Laura B., Meyer, Sara C., Takiguchi, Megumi, Dickins, Ross A., Levine, Ross, Ghysdael, Jacques, Dawson, Mark A., Lock, Richard B., Mullighan, Charles G., Johnstone, Ricky W.
Published in Cell reports (Cambridge) (27.11.2013)
Published in Cell reports (Cambridge) (27.11.2013)
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Evaluation of the in vitro and in vivo efficacy of the JAK inhibitor AZD1480 against JAK-mutated acute lymphoblastic leukemia
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Published in Molecular cancer therapeutics (01.02.2015)
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AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia
Moradi Manesh, Donya, El-Hoss, Jad, Evans, Kathryn, Richmond, Jennifer, Toscan, Cara E., Bracken, Lauryn S., Hedrick, Ashlee, Sutton, Rosemary, Marshall, Glenn M., Wilson, William R., Kurmasheva, Raushan T., Billups, Catherine, Houghton, Peter J., Smith, Malcolm A., Carol, Hernan, Lock, Richard B.
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Published in Blood (03.09.2015)
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ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling
Goossens, Steven, Radaelli, Enrico, Blanchet, Odile, Durinck, Kaat, Van der Meulen, Joni, Peirs, Sofie, Taghon, Tom, Tremblay, Cedric S., Costa, Magdaline, Ghahremani, Morvarid Farhang, De Medts, Jelle, Bartunkova, Sonia, Haigh, Katharina, Schwab, Claire, Farla, Natalie, Pieters, Tim, Matthijssens, Filip, Van Roy, Nadine, Best, J. Adam, Deswarte, Kim, Bogaert, Pieter, Carmichael, Catherine, Rickard, Adam, Suryani, Santi, Bracken, Lauryn S., Alserihi, Raed, Canté-Barrett, Kirsten, Haenebalcke, Lieven, Clappier, Emmanuelle, Rondou, Pieter, Slowicka, Karolina, Huylebroeck, Danny, Goldrath, Ananda W., Janzen, Viktor, McCormack, Matthew P., Lock, Richard B., Curtis, David J., Harrison, Christine, Berx, Geert, Speleman, Frank, Meijerink, Jules P. P., Soulier, Jean, Van Vlierberghe, Pieter, Haigh, Jody J.
Published in Nature communications (07.01.2015)
Published in Nature communications (07.01.2015)
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