A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors
Jimeno, Antonio, Gordon, Michael, Chugh, Rashmi, Messersmith, Wells, Mendelson, David, Dupont, Jakob, Stagg, Robert, Kapoun, Ann M, Xu, Lu, Uttamsingh, Shailaja, Brachmann, Rainer K, Smith, David C
Published in Clinical cancer research (15.12.2017)
Published in Clinical cancer research (15.12.2017)
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Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer
Diamond, Jennifer R., Becerra, Carlos, Richards, Donald, Mita, Alain, Osborne, Cynthia, O’Shaughnessy, Joyce, Zhang, Chun, Henner, Randall, Kapoun, Ann M., Xu, Lu, Stagg, Bob, Uttamsingh, Shailaja, Brachmann, Rainer K., Farooki, Azeez, Mita, Monica
Published in Breast cancer research and treatment (01.11.2020)
Published in Breast cancer research and treatment (01.11.2020)
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Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer
Dotan, Efrat, Cardin, Dana B, Lenz, Heinz-Josef, Messersmith, Wells, O'Neil, Bert, Cohen, Steven J, Denlinger, Crystal S, Shahda, Safi, Astsaturov, Igor, Kapoun, Ann M, Brachmann, Rainer K, Uttamsingh, Shailaja, Stagg, Robert J, Weekes, Colin
Published in Clinical cancer research (15.10.2020)
Published in Clinical cancer research (15.10.2020)
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Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53
Wang, Ting, Zeng, Jue, Lowe, Craig B, Sellers, Robert G, Salama, Sofie R, Yang, Min, Burgess, Shawn M, Brachmann, Rainer K, Haussler, David
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2007)
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Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models
SPOERKE, Jill M, O'BRIEN, Carol, FRIEDMAN, Lori S, ROSS, Leanne, HAMPTON, Garret M, AMLER, Lukas C, SHAMES, David S, LACKNER, Mark R, HUW, Ling, KOEPPEN, Hartmut, FRIDLYAND, Jane, BRACHMANN, Rainer K, HAVERTY, Peter M, PANDITA, Ajay, MOHAN, Sankar, SAMPATH, Deepak
Published in Clinical cancer research (15.12.2012)
Published in Clinical cancer research (15.12.2012)
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A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors
Weekes, Colin D., Beeram, Muralidhar, Tolcher, Anthony W., Papadopoulos, Kyriakos P., Gore, Lia, Hegde, Priti, Xin, Yan, Yu, Ron, Shih, L. Mason, Xiang, Hong, Brachmann, Rainer K., Patnaik, Amita
Published in Investigational new drugs (01.08.2014)
Published in Investigational new drugs (01.08.2014)
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A Phase Ib study evaluating MNRP1685A, a fully human anti-NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors
Patnaik, Amita, LoRusso, Patricia M., Messersmith, Wells A., Papadopoulos, Kyriakos P., Gore, Lia, Beeram, Muralidhar, Ramakrishnan, Vanitha, Kim, Amy H., Beyer, Joseph C., Mason Shih, L., Darbonne, Walter C., Xin, Yan, Yu, Ron, Xiang, Hong, Brachmann, Rainer K., Weekes, Colin D.
Published in Cancer chemotherapy and pharmacology (01.05.2014)
Published in Cancer chemotherapy and pharmacology (01.05.2014)
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Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers
Dearth, Lawrence R., Qian, Hua, Wang, Ting, Baroni, Timothy E., Zeng, Jue, Chen, Stephanie W., Yi, Sun Young, Brachmann, Rainer K.
Published in Carcinogenesis (New York) (01.02.2007)
Published in Carcinogenesis (New York) (01.02.2007)
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Anti-Neuropilin-1 (MNRP1685A): Unexpected Pharmacokinetic Differences Across Species, from Preclinical Models to Humans
Xin, Yan, Bai, Shuang, Damico-Beyer, Lisa A., Jin, Denise, Liang, Wei-Ching, Wu, Yan, Theil, Frank-Peter, Joshi, Amita, Lu, Yanmei, Lowe, John, Maia, Mauricio, Brachmann, Rainer K., Xiang, Hong
Published in Pharmaceutical research (01.09.2012)
Published in Pharmaceutical research (01.09.2012)
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p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5
Kobayashi, Takahiko, Ishida, Junich, Musashi, Manabu, Ota, Shuichi, Yoshida, Takeshi, Shimizu, Yuichi, Chuma, Makoto, Kawakami, Hiroshi, Asaka, Masahiro, Tanaka, Junji, Imamura, Masahiro, Kobayashi, Masanobu, Itoh, Hiroshi, Edamatsu, Hironori, Sutherland, Leslie C., Brachmann, Rainer K.
Published in International journal of cancer (15.01.2011)
Published in International journal of cancer (15.01.2011)
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A Global Suppressor Motif for p53 Cancer Mutants
Baroni, Timothy E., Wang, Ting, Qian, Hua, Dearth, Lawrence R., Truong, Lan N., Zeng, Jue, Denes, Alec E., Chen, Stephanie W., Brachmann, Rainer K., Korsmeyer, Stanley J.
Published in Proceedings of the National Academy of Sciences - PNAS (06.04.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (06.04.2004)
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Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins
Zeng, Jue, Yan, Jizhou, Wang, Ting, Mosbrook-Davis, Deborah, Dolan, Kyle T, Christensen, Ryan, Stormo, Gary D, Haussler, David, Lathrop, Richard H, Brachmann, Rainer K, Burgess, Shawn M
Published in Nucleic acids research (01.01.2008)
Published in Nucleic acids research (01.01.2008)
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Overexpression of the oncoprotein prothymosin α triggers a p53 response that involves p53 acetylation
KOBAYASHI, Takahiko, TING WANG, TANAKA, Junji, IMAMURA, Masahiro, HASEGAWA, Kiminori, TANAKA, Yoshiyuki, BRACHMANN, Rainer K, MAEZAWA, Masaji, KOBAYASHI, Masanobu, OHNISHI, Shunsuke, HATANAKA, Kazuteru, HIGE, Shuhei, SHIMIZU, Yuichi, KATO, Mototsugu, ASAKA, Masahiro
Published in Cancer research (Chicago, Ill.) (15.03.2006)
Published in Cancer research (Chicago, Ill.) (15.03.2006)
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Journal Article
hADA3 is required for p53 activity
Wang, Ting, Kobayashi, Takahiko, Takimoto, Rishu, Denes, Alec E., Snyder, Eric L., el-Deiry, Wafik S., Brachmann, Rainer K.
Published in The EMBO journal (15.11.2001)
Published in The EMBO journal (15.11.2001)
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Journal Article
Dominant-Negative p53 Mutations Selected in Yeast Hit Cancer Hot Spots
Brachmann, Rainer K., Vidal, Marc, Boeke, Jef D.
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.1996)
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