EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL
Brach, Dorothy, Johnston-Blackwell, Danielle, Drew, Allison, Lingaraj, Trupti, Motwani, Vinny, Warholic, Natalie M, Feldman, Igor, Plescia, Christopher, Smith, Jesse J, Copeland, Robert A, Keilhack, Heike, Chan-Penebre, Elayne, Knutson, Sarah K, Ribich, Scott A, Raimondi, Alejandra, Thomenius, Michael J
Published in Molecular cancer therapeutics (01.11.2017)
Published in Molecular cancer therapeutics (01.11.2017)
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Journal Article
Abstract B011: Synergistic activity of tazemetostat in combination with androgen signaling inhibitors in preclinical models of prostate cancer demonstrates potential for clinical expansion
Motwani, Vinny, Brach, Dorothy, Pantano, Chloe, Estanek, Vania, Keats, Jeffrey A., Dransfield, Daniel T., Raimondi, Alejandra
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Pharmacologic Inhibition of the Histone Methyltransferase SETD2 with EZM0414 As a Novel Therapeutic Strategy in Relapsed or Refractory Multiple Myeloma and Diffuse Large B-Cell Lymphoma
Totman, Jennifer, Brach, Dorothy, Motwani, Vinny, Howe, Selene, Deutschman, Emily, Lampe, John, Riera, Thomas V., Tang, Cuyue, Eckley, Sean T., Alford, Josh, Duncan, Kenneth W., Farrow, Neil A., Dransfield, Daniel T., Raimondi, Alejandra, Thomeius, Michael J., Cosmopoulos, Kat, Kutok, Jeffery L
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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SETD2 억제제를 사용한 조합 요법
RAIMONDI MARIA ALEJANDRA, COSMOPOULOS KATHERINE LOUISE, TOTMAN JENNIFER ANNE, MOTWANI VINNY, BRACH DOROTHY, DRANSFIELD DANIEL T
Year of Publication 14.02.2024
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Year of Publication 14.02.2024
Patent
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation
Thomenius, Michael J, Totman, Jennifer, Harvey, Darren, Mitchell, Lorna H, Riera, Thomas V, Cosmopoulos, Kat, Grassian, Alexandra R, Klaus, Christine, Foley, Megan, Admirand, Elizabeth A, Jahic, Haris, Majer, Christina, Wigle, Tim, Jacques, Suzanne L, Gureasko, Jodi, Brach, Dorothy, Lingaraj, Trupti, West, Kip, Smith, Sherri, Rioux, Nathalie, Waters, Nigel J, Tang, Cuyue, Raimondi, Alejandra, Munchhof, Michael, Mills, James E, Ribich, Scott, Porter Scott, Margaret, Kuntz, Kevin W, Janzen, William P, Moyer, Mikel, Smith, Jesse J, Chesworth, Richard, Copeland, Robert A, Boriack-Sjodin, P Ann
Published in PloS one (01.06.2018)
Published in PloS one (01.06.2018)
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Abstract 1768: Identification of a potent, orally-available SMARCA2/4 inhibitor with in vitro and in vivo activity in preclinical models of SMARCA4-mutant NSCLC
Drew, Allison E., Jacques, Suzanne L., Eichinger, Lindsey W., Pantano, Chloe, Motwani, Vinny, Tang, Cuyue, Farrow, Neil, Brach, Dorothy, Howe, Selene, Raimondi, Alejandra, Dransfield, Daniel T., Duncan, Kenneth W., Stickland, Kim, Huang, Liyue, Lampe, John
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 2924: Aberrant SWI/SNF complexes lacking SMARCA2 or SMARCA4 differentially affect cell state and response to a novel SMARCA2/4 inhibitor
Eichinger, Lindsey W., Pantano, Chloe, Motwani, Vinny, Brach, Dorothy, Howe, Selene, Raimondi, Alejandra, Dransfield, Daniel T., Duncan, Kenneth W., Stickland, Kim, Tang, Cuyue, Farrow, Neil A., Lampe, John, Jacques, Suzanne L., Drew, Allison E.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Identification of a First-in-Class SETD2 Inhibitor That Shows Potent and Selective Anti-Proliferative Activity in t(4;14) Multiple Myeloma: T(4;14) Multiple Myeloma Cells Are Dependent on Both H3K36 Di and Tri-Methylation
Thomenius, Michael J, Totman, Jennifer, Cosmopoulos, Kat, Brach, Dorothy, Ci, Lei, Farrow, Neil, Smith, Jesse J, Chesworth, Richard, Duncan, Kenneth W., Tang, Cuyue, Riera, Thomas, Lampe, John
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies
Alford, Joshua S., Lampe, John W., Brach, Dorothy, Chesworth, Richard, Cosmopoulos, Kat, Duncan, Kenneth W., Eckley, Sean T., Kutok, Jeffrey L., Raimondi, Alejandra, Riera, Thomas V., Shook, Brian, Tang, Cuyue, Totman, Jennifer, Farrow, Neil A.
Published in ACS medicinal chemistry letters (14.07.2022)
Published in ACS medicinal chemistry letters (14.07.2022)
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Journal Article
Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies
Lampe, John W, Alford, Joshua S, Boriak-Sjodin, P. Ann, Brach, Dorothy, Cosmopoulos, Kat, Duncan, Kenneth W, Eckley, Sean T, Foley, Megan A, Harvey, Darren M, Motwani, Vinny, Munchhof, Michael J, Raimondi, Alejandra, Riera, Thomas V, Tang, Cuyue, Thomenius, Michael J, Totman, Jennifer, Farrow, Neil A
Published in ACS medicinal chemistry letters (14.10.2021)
Published in ACS medicinal chemistry letters (14.10.2021)
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Journal Article
Abstract 3345: Selective killing of SMARCA2- and SMARCA4-deficient tumors by inhibition of EZH2: In vitro and in vivo preclinical models
Chan-Penebre, Elayne, Armstrong, Kelli, Drew, Allison, Grassian, Alexandra R., Feldman, Igor, Roche, Maria, Ho, Peter, Brach, Dorothy, Raimondi, Alejandra, Copeland, Robert A., Chesworth, Richard, Smith, Jesse J., Ribich, Scott A.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Reawakening of Human Fetal Hemoglobin and an Epigenetic Path to the Clinic for Sickle Cell Disease and Beta-Thalassemia: Identification of an Orally-Available, Potent, and Selective Euchromatic Histone Lysine Methyltransferase 1 and 2 (EHMT1/2) Inhibitor
Chan-Penebre, Elayne, Gibaja, Veronica, Campbell, John, Olu, Ogunbodede, Admirand, Elizabeth, Brach, Dorothy, Tang, Cuyue, Raimondi, Alejandra, Hood, Tami, Cocozaki, Alexis, Karaman, Sule, Stickland, Kimberly, Plescia, Christopher, Munchhof, Michael, Armstrong, Kelli, Riera, Thomas, Orkin, Stuart, Boriack-Sjodin, Ann, Janzen, William, Blakemore, Stephen, Ribich, Scott A, Chesworth, Richard, Smith, Jesse J, Duncan, Kenneth W
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Abstract B85: EZH2 plays a critical role in B-cell maturation and in non-Hodgkin's lymphoma: Interplay between EZH2 function and B-cell activation
Johnston, Danielle, Brach, Dorothy, Plescia, Christopher, Drew, Alison, Lingaraj, Trupti, Warholic, Natalie, Smith, Jesse J., Copeland, Robert A., Keilhack, Heike, Penebre, Elayne, Knutson, Sarah K., Ribich, Scott, Thomenius, Michael J., Raimondi, Alejandra
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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