Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened
Munchhof, Michael J, Li, Qifang, Shavnya, Andrei, Borzillo, Gary V, Boyden, Tracey L, Jones, Christopher S, LaGreca, Susan D, Martinez-Alsina, Luis, Patel, Nandini, Pelletier, Kathleen, Reiter, Larry A, Robbins, Michael D, Tkalcevic, George T
Published in ACS medicinal chemistry letters (09.02.2012)
Published in ACS medicinal chemistry letters (09.02.2012)
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Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Helal, Christopher J, Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A, Fennell, Kimberly F, Forman, Michael D, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, LaChapelle, Erik A, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O’Connor, Rebecca E, Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W, Schmidt, Christopher J, Ueno, Hirokazu, Verhoest, Patrick R, Yang, Edward X
Published in Journal of medicinal chemistry (26.04.2018)
Published in Journal of medicinal chemistry (26.04.2018)
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Metabolism Distribution and Excretion of a Matrix Metalloproteinase-13 Inhibitor, 4-[4-(4-Fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic Acid Hydroxyamide (CP-544439), in Rats and Dogs: Assessment of the Metabolic Profile of CP-544439 in Plasma and Urine of Humans
DALVIE, Deepak, COSKER, Theresa, BOYDEN, Tracey, ZHOU, Sue, SCHROEDER, Clinton, POTCHOIBA, Michael J
Published in Drug metabolism and disposition (01.09.2008)
Published in Drug metabolism and disposition (01.09.2008)
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Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Helal, Christopher J, Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A, Fennell, Kimberly F, Forman, Michael D, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O’Connor, Rebecca E, Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W, Schmidt, Christopher J, Ueno, Hirokazu, Verhoest, Patrick R, Yang, Edward X
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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Investigating CNS distribution of PF‐05212377, a P‐glycoprotein substrate, by translation of 5‐HT6 receptor occupancy from non‐human primates to humans
Sawant‐Basak, Aarti, Chen, Laigao, Lockwood, Peter, Boyden, Tracey, Doran, Angela C., Mancuso, Jessica, Zasadny, Kenneth, McCarthy, Timothy, Morris, Evan D., Carson, Richard E., Esterlis, Irina, Huang, Yiyun, Nabulsi, Nabeel, Planeta, Beata, Fullerton, Terence
Published in Biopharmaceutics & drug disposition (01.02.2023)
Published in Biopharmaceutics & drug disposition (01.02.2023)
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Journal Article
Investigating CNS distribution of PF-05212377, a P-glycoprotein substrate, by translation of 5-HT 6 receptor occupancy from non-human primates to humans
Sawant-Basak, Aarti, Chen, Laigao, Lockwood, Peter, Boyden, Tracey, Doran, Angela C, Mancuso, Jessica, Zasadny, Kenneth, McCarthy, Timothy, Morris, Evan D, Carson, Richard E, Esterlis, Irina, Huang, Yiyun, Nabulsi, Nabeel, Planeta, Beata, Fullerton, Terence
Published in Biopharmaceutics & drug disposition (01.02.2023)
Published in Biopharmaceutics & drug disposition (01.02.2023)
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Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate
Helal, Christopher J, Arnold, Eric, Boyden, Tracey, Chang, Cheng, Chappie, Thomas A, Fisher, Ethan, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Pandit, Jayvardhan, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, McGinnis, Dina, O’Connor, Rebecca E, O’Donnell, Christopher J, Ogden, Adam, Piotrowski, Mary, Schmidt, Christopher J, Seymour, Patricia A, Ueno, Hirokazu, Vansell, Nichole, Verhoest, Patrick R, Yang, Edward X
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Preclinical Evaluation of 18 F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme
Chen, Laigao, Nabulsi, Nabeel, Naganawa, Mika, Zasadny, Kenneth, Skaddan, Marc B., Zhang, Lei, Najafzadeh, Soheila, Lin, Shu-fei, Helal, Christopher J., Boyden, Tracey L., Chang, Cheng, Ropchan, Jim, Carson, Richard E., Villalobos, Anabella, Huang, Yiyun
Published in Journal of Nuclear Medicine (01.09.2016)
Published in Journal of Nuclear Medicine (01.09.2016)
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Preclinical Evaluation of ^sup 18^F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme
Chen, Laigao, Nabulsi, Nabeel, Naganawa, Mika, Zasadny, Kenneth, Skaddan, Marc B, Zhang, Lei, Najafzadeh, Soheila, Lin, Shu-fei, Helal, Christopher J, Boyden, Tracey L, Chang, Cheng, Ropchan, Jim, Carson, Richard E, Villalobos, Anabella, Huang, Yiyun
Published in The Journal of nuclear medicine (1978) (01.09.2016)
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Published in The Journal of nuclear medicine (1978) (01.09.2016)
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Preclinical Evaluation of super( 18)F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme
Chen, Laigao, Nabulsi, Nabeel, Naganawa, Mika, Zasadny, Kenneth, Skaddan, Marc B, Zhang, Lei, Najafzadeh, Soheila, Lin, Shu-fei, Helal, Christopher J, Boyden, Tracey L, Chang, Cheng, Ropchan, Jim, Carson, Richard E, Villalobos, Anabella, Huang, Yiyun
Published in The Journal of nuclear medicine (1978) (01.09.2016)
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Published in The Journal of nuclear medicine (1978) (01.09.2016)
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Inhaled PYY(3-36) dry-powder formulation for appetite suppression
Kuehl, Philip J, Boyden, Tracey, Dobry, Dan E, Doyle-Eisele, Melanie, Friesen, Dwayne T, McDonald, Jacob D, Murri, Brice G, Vodak, David T, Lyon, David K
Published in Drug development and industrial pharmacy (02.01.2016)
Published in Drug development and industrial pharmacy (02.01.2016)
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P4‐253: Receptor occupancy of the 5‐HT6 receptor antagonist SAM‐760 in non‐human primates and healthy human volunteers
Comery, Thomas, Zasadny, Kenneth, Morris, Evan, Antinew, Jeremias, Bell, Joanne, Billing, Bill, Boyden, Tracey, Esterlis, Irene, Huang, Yiyun, Kupiec, James, Kuszpit, Kyle, Leil, Tarek, Nabulsi, Nabeel, Planeta‐Wilson, Beata, Plotka, Anna, Skaddan, Marc, Vandal, Grace, Carson, Richard, Katz, Elyse, McCarthy, Timothy
Published in Alzheimer's & dementia (01.07.2011)
Published in Alzheimer's & dementia (01.07.2011)
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Receptor occupancy of the 5-HT6 receptor antagonist SAM-760 in non-human primates and healthy human volunteers
Comery, Thomas, Zasadny, Kenneth, Morris, Evan, Antinew, Jeremias, Bell, Joanne, Billing, Bill, Boyden, Tracey, Esterlis, Irene, Huang, Yiyun, Kupiec, James, Kuszpit, Kyle, Leil, Tarek, Nabulsi, Nabeel, Planeta-Wilson, Beata, Plotka, Anna, Skaddan, Marc, Vandal, Grace, Carson, Richard, Katz, Elyse, McCarthy, Timothy
Published in Alzheimer's & dementia (01.07.2011)
Published in Alzheimer's & dementia (01.07.2011)
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