8‑Substituted Pyrido[3,4‑d]pyrimidin-4(3H)‑one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors
Bavetsias, Vassilios, Lanigan, Rachel M, Ruda, Gian Filippo, Atrash, Butrus, McLaughlin, Mark G, Tumber, Anthony, Mok, N. Yi, Le Bihan, Yann-Vaï, Dempster, Sally, Boxall, Katherine J, Jeganathan, Fiona, Hatch, Stephanie B, Savitsky, Pavel, Velupillai, Srikannathasan, Krojer, Tobias, England, Katherine S, Sejberg, Jimmy, Thai, Ching, Donovan, Adam, Pal, Akos, Scozzafava, Giuseppe, Bennett, James M, Kawamura, Akane, Johansson, Catrine, Szykowska, Aleksandra, Gileadi, Carina, Burgess-Brown, Nicola A, von Delft, Frank, Oppermann, Udo, Walters, Zoe, Shipley, Janet, Raynaud, Florence I, Westaway, Susan M, Prinjha, Rab K, Fedorov, Oleg, Burke, Rosemary, Schofield, Christopher J, Westwood, Isaac M, Bountra, Chas, Müller, Susanne, van Montfort, Rob L. M, Brennan, Paul E, Blagg, Julian
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5‑b]pyridine Derivatives as Highly Selective Inhibitors of Aurora‑A Kinase in Cells
Bavetsias, Vassilios, Faisal, Amir, Crumpler, Simon, Brown, Nathan, Kosmopoulou, Magda, Joshi, Amar, Atrash, Butrus, Pérez-Fuertes, Yolanda, Schmitt, Jessica A, Boxall, Katherine J, Burke, Rosemary, Sun, Chongbo, Avery, Sian, Bush, Katherine, Henley, Alan, Raynaud, Florence I, Workman, Paul, Bayliss, Richard, Linardopoulos, Spiros, Blagg, Julian
Published in Journal of medicinal chemistry (27.11.2013)
Published in Journal of medicinal chemistry (27.11.2013)
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CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors
ANDERSON, Victoria E, WALTON, Michael I, GARRETT, Michelle D, EVE, Paul D, BOXALL, Katherine J, ANTONI, Laurent, CALDWELL, John J, AHERNE, Wynne, PEARL, Laurence H, OLIVER, Antony W, COLLINS, Ian
Published in Cancer research (Chicago, Ill.) (15.01.2011)
Published in Cancer research (Chicago, Ill.) (15.01.2011)
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Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)‑5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)
Osborne, James D, Matthews, Thomas P, McHardy, Tatiana, Proisy, Nicolas, Cheung, Kwai-Ming J, Lainchbury, Michael, Brown, Nathan, Walton, Michael I, Eve, Paul D, Boxall, Katherine J, Hayes, Angela, Henley, Alan T, Valenti, Melanie R, De Haven Brandon, Alexis K, Box, Gary, Jamin, Yann, Robinson, Simon P, Westwood, Isaac M, van Montfort, Rob L. M, Leonard, Philip M, Lamers, Marieke B. A. C, Reader, John C, Aherne, G. Wynne, Raynaud, Florence I, Eccles, Suzanne A, Garrett, Michelle D, Collins, Ian
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
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Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange
Oliver, Antony W, Paul, Angela, Boxall, Katherine J, Barrie, S Elaine, Aherne, G Wynne, Garrett, Michelle D, Mittnacht, Sibylle, Pearl, Laurence H
Published in The EMBO journal (12.07.2006)
Published in The EMBO journal (12.07.2006)
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The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors
Cheung, Kwai-Ming J., Matthews, Thomas P., James, Karen, Rowlands, Martin G., Boxall, Katherine J., Sharp, Swee Y., Maloney, Alison, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence H., Aherne, G. Wynne, McDonald, Edward, Workman, Paul
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
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Microfluidic Mobility Shift Assay for Real-Time Analysis of Peptide N-Palmitoylation
Lanyon-Hogg, Thomas, Patel, Neki V., Ritzefeld, Markus, Boxall, Katherine J., Burke, Rosemary, Blagg, Julian, Magee, Anthony I., Tate, Edward W.
Published in SLAS discovery (01.04.2017)
Published in SLAS discovery (01.04.2017)
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CCT241533 is a potent and selective inhibitor of CHK2 which potentiates the cytotoxicity of PARP inhibitors
Anderson, Victoria E, Walton, Michael I, Eve, Paul D, Boxall, Katherine J, Antoni, Laurent, Caldwell, John J, Pearl, Laurence H, Oliver, Antony W, Collins, Ian, Garrett, Michelle D
Published in Cancer research (Chicago, Ill.) (15.01.2011)
Published in Cancer research (Chicago, Ill.) (15.01.2011)
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