Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)
Rice, Kenneth D, Aay, Naing, Anand, Neel K, Blazey, Charles M, Bowles, Owen J, Bussenius, Joerg, Costanzo, Simona, Curtis, Jeffry K, Defina, Steven C, Dubenko, Larisa, Engst, Stefan, Joshi, Anagha A, Kennedy, Abigail R, Kim, Angie I, Koltun, Elena S, Lougheed, Julie C, Manalo, Jean-Claire L, Martini, Jean-Francois, Nuss, John M, Peto, Csaba J, Tsang, Tsze H, Yu, Peiwen, Johnston, Stuart
Published in ACS medicinal chemistry letters (10.05.2012)
Published in ACS medicinal chemistry letters (10.05.2012)
Get full text
Journal Article
Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90
Bussenius, Joerg, Blazey, Charles M., Aay, Naing, Anand, Neel K., Arcalas, Arlyn, Baik, TaeGon, Bowles, Owen J., Buhr, Chris A., Costanzo, Simona, Curtis, Jeffrey K., DeFina, Steven C., Dubenko, Larisa, Heuer, Timothy S., Huang, Ping, Jaeger, Christopher, Joshi, Anagha, Kennedy, Abigail R., Kim, Angie I., Lara, Katherine, Lee, Jae, Li, Jonathan, Lougheed, Julie C., Ma, Sunghoon, Malek, Shiva, Manalo, Jean-Claire L., Martini, Jean-Francois, McGrath, Garth, Nicoll, Monique, Nuss, John M., Pack, Michael, Peto, Csaba J., Tsang, Tsze H., Wang, Longcheng, Womble, Scott W., Yakes, Michael, Zhang, Wentao, Rice, Kenneth D.
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Get full text
Journal Article
Pyrazolopyrimidines as dual Akt/p70S6K inhibitors
Rice, Kenneth D., Kim, Moon H., Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Canne-Bannen, Lynne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Klein, Rhett R., Laird, A.Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Get full text
Journal Article
Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors
Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Bannen, Lynne Canne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Kim, Moon H., Klein, Rhett R., Laird, Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei, Rice, Kenneth D.
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
Get full text
Journal Article
Tuning "kappticity" of tripodal ligands
Friesen, Dawn M, Bowles, Owen J, McDonald, Robert, Rosenberg, Lisa
Published in Dalton transactions : an international journal of inorganic chemistry (14.06.2006)
Published in Dalton transactions : an international journal of inorganic chemistry (14.06.2006)
Get more information
Journal Article
Anaplastic lymphoma kinase modulators and methods of use
KIM ANGIE I, BOWLES OWEN J, MANALO JEAN-CLAIRE L, COSTANZO SIMONA, KENNEDY ABIGAIL R, KHOURY RICHARD G, ANAND NEEL K, BUSSENIUS JOERG, CURTIS JEFFRY K, TSANG TSZE H, BLAZEY CHARLES M, PETO CSABA J, RICE KENNETH D, DUBENKO LARISA
Year of Publication 08.02.2007
Get full text
Year of Publication 08.02.2007
Patent
Raf Modulators and Methods of Use
KIM ANGIE I, JOSHI ANAGHA A, BOWLES OWEN J, MANALO JEAN-CLAIRE L, COSTANZO SIMONA, KENNEDY ABIGAIL R, ANAND NEEL K, BUSSENIUS JOERG, CURTIS JEFFRY K, TSANG TSZE H, DEFINA STEVEN C, BLAZEY CHARLES M, PETO CSABA J, RICE KENNETH D, DUBENKO LARISA
Year of Publication 10.01.2008
Get full text
Year of Publication 10.01.2008
Patent
COMPUESTO DE TROPANO COMO INHIBIDORES DE HSP90
BOWLES OWEN J, MANALO JEAN-CLAIRE, BAIK TAEGON, WANG LONGCHENG, ARCALAS ARLYN, PETO CSABA, AAY NAING, COSTANZO SIMONA, KENNEDY ABIGAIL R, DEFINA STEVEN, ANAND NEEL KUMAR, BUHR CHRIS A, CURTIS JEFF KIMO, BUSSENIUS JOERG, BLAZEY CHARLES M, LARA KATHERINE, RICE KENNETH D, DUBENKO LARISA, MA SUNGHOON
Year of Publication 20.09.2011
Get full text
Year of Publication 20.09.2011
Patent
AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES MEK
DeFina, Steven Charles SC, KENNEDY, Abigail R. AR, BOWLES, Owen Joseph OJ, AAY, Naing N, ANAND, Neel Kumar NK, MANALO, Jean-Claire Limun J-CL, DUBENKO, Larisa L, KIM, Angie Inyoung AI, COSTANZO, Simona S, KOLTUN, Elena E, JOSHI, Anagha Abhijit AA, BLAZEY, Charles M. CM, RICE, Kenneth D. KD, TSANG, Tsze H. TH, CURTIS, Jeffry Kimo JK, BUSSENIUS, Joerg J, PETO, Csaba J. CJ
Year of Publication 29.07.2016
Get full text
Year of Publication 29.07.2016
Patent