RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
Picaud, Sarah, Wells, Christopher, Felletar, Ildiko, Brotherton, Deborah, Martin, Sarah, Savitsky, Pavel, Diez-Dacal, Beatriz, Philpott, Martin, Bountra, Chas, Lingard, Hannah, Fedorov, Oleg, Müller, Susanne, Brennan, Paul E., Knapp, Stefan, Filippakopoulos, Panagis
Published in Proceedings of the National Academy of Sciences - PNAS (03.12.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (03.12.2013)
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Mutant Prolactin Receptor and Familial Hyperprolactinemia
Newey, Paul J, Gorvin, Caroline M, Cleland, Stephen J, Willberg, Christian B, Bridge, Marcus, Azharuddin, Mohammed, Drummond, Russell S, van der Merwe, P. Anton, Klenerman, Paul, Bountra, Chas, Thakker, Rajesh V
Published in The New England journal of medicine (21.11.2013)
Published in The New England journal of medicine (21.11.2013)
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Journal Article
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells
Tumber, Anthony, Nuzzi, Andrea, Hookway, Edward S., Hatch, Stephanie B., Velupillai, Srikannathasan, Johansson, Catrine, Kawamura, Akane, Savitsky, Pavel, Yapp, Clarence, Szykowska, Aleksandra, Wu, Na, Bountra, Chas, Strain-Damerell, Claire, Burgess-Brown, Nicola A., Ruda, Gian Filippo, Fedorov, Oleg, Munro, Shonagh, England, Katherine S., Nowak, Radoslaw P., Schofield, Christopher J., La Thangue, Nicholas B., Pawlyn, Charlotte, Davies, Faith, Morgan, Gareth, Athanasou, Nick, Müller, Susanne, Oppermann, Udo, Brennan, Paul E.
Published in Cell chemical biology (16.03.2017)
Published in Cell chemical biology (16.03.2017)
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EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial
Rice, Andrew S C, Prof, Dworkin, Robert H, Prof, McCarthy, Tom D, PhD, Anand, Praveen, Prof, Bountra, Chas, Prof, McCloud, Philip I, PhD, Hill, Julie, MSc, Cutter, Gary, Prof, Kitson, Geoff, BM BS, Desem, Nuket, MBA, Raff, Milton, FCA [SA]
Published in The Lancet (British edition) (10.05.2014)
Published in The Lancet (British edition) (10.05.2014)
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Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states
Shintre, Chitra A., Pike, Ashley C. W., Li, Qiuhong, Kim, Jung-In, Barr, Alastair J., Goubin, Solenne, Shrestha, Leela, Yang, Jing, Berridge, Georgina, Ross, Jonathan, Stansfeld, Phillip J., Sansom, Mark S. P., Edwards, Aled M., Bountra, Chas, Marsden, Brian D., von Delft, Frank, Bullock, Alex N., Gileadi, Opher, Burgess-Brown, Nicola A., Carpenter, Elisabeth P.
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
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Journal Article
Mechanisms Underlying Clinical Efficacy of Angiotensin II Type 2 Receptor (AT2R) Antagonist EMA401 in Neuropathic Pain: Clinical Tissue and in Vitro Studies
Anand, Uma, Yiangou, Yiangos, Sinisi, Marco, Fox, Michael, MacQuillan, Anthony, Quick, Tom, Korchev, Yuri E, Bountra, Chas, McCarthy, Tom, Anand, Praveen
Published in Molecular pain (26.06.2015)
Published in Molecular pain (26.06.2015)
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COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
Yiangou, Yiangos, Facer, Paul, Durrenberger, Pascal, Chessell, Iain P, Naylor, Alan, Bountra, Chas, Banati, Richard R, Anand, Praveen
Published in BMC neurology (02.03.2006)
Published in BMC neurology (02.03.2006)
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Journal Article
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
CHESSELL, Iain P, HATCHER, Jonathan P, GRAHAMES, Caroline B. A, CASULA, Maria Anna, YIANGOU, Yiangos, BIRCH, Rolfe, ANAND, Praveen, BUELL, Gary N, BOUNTRA, Chas, MICHEL, Anton D, HUGHES, Jane P, GREEN, Paula, EGENON, Julie, MURFIN, Melanie, RICHARDSON, Jill, PECK, Wendy L
Published in Pain (Amsterdam) (01.04.2005)
Published in Pain (Amsterdam) (01.04.2005)
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Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy
Facer, Paul, Casula, Maria A, Smith, Graham D, Benham, Christopher D, Chessell, Iain P, Bountra, Chas, Sinisi, Marco, Birch, Rolfe, Anand, Praveen
Published in BMC neurology (23.05.2007)
Published in BMC neurology (23.05.2007)
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Journal Article
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors
Vazquez‐Rodriguez, Saleta, Wright, Miranda, Rogers, Catherine M., Cribbs, Adam P., Velupillai, Srikannathasan, Philpott, Martin, Lee, Henry, Dunford, James E., Huber, Kilian V. M., Robers, Matthew B., Vasta, James D., Thezenas, Marie‐Laetitia, Bonham, Sarah, Kessler, Benedikt, Bennett, James, Fedorov, Oleg, Raynaud, Florence, Donovan, Adam, Blagg, Julian, Bavetsias, Vassilios, Oppermann, Udo, Bountra, Chas, Kawamura, Akane, Brennan, Paul E.
Published in Angewandte Chemie International Edition (08.01.2019)
Published in Angewandte Chemie International Edition (08.01.2019)
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Journal Article
Collaboration and knowledge integration for successful brain therapeutics - lessons learned from the pandemic
Loza, Maria Isabel, Hmeljak, Julija, Bountra, Chas, Audia, James E, Chowdhury, Sohini, Weiman, Shannon, Merchant, Kalpana, Blanco, Maria-Jesus
Published in Disease models & mechanisms (01.12.2022)
Published in Disease models & mechanisms (01.12.2022)
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Journal Article
The Structural Basis of ZMPSTE24-Dependent Laminopathies
Quigley, Andrew, Dong, Yin Yao, Pike, Ashley C. W., Dong, Liang, Shrestha, Leela, Berridge, Georgina, Stansfeld, Phillip J., Sansom, Mark S. P., Edwards, Aled M., Bountra, Chas, von Delft, Frank, Bullock, Alex N., Burgess-Brown, Nicola A., Carpenter, Elisabeth P.
Published in Science (American Association for the Advancement of Science) (29.03.2013)
Published in Science (American Association for the Advancement of Science) (29.03.2013)
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Leveraging crowdsourcing to facilitate the discovery of new medicines
Norman, Thea C, Bountra, Chas, Edwards, Aled M, Yamamoto, Keith R, Friend, Stephen H
Published in Science translational medicine (22.06.2011)
Published in Science translational medicine (22.06.2011)
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Journal Article
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance
Fedorov, Oleg, Castex, Josefina, Tallant, Cynthia, Owen, Dafydd R, Martin, Sarah, Aldeghi, Matteo, Monteiro, Octovia, Filippakopoulos, Panagis, Picaud, Sarah, Trzupek, John D, Gerstenberger, Brian S, Bountra, Chas, Willmann, Dominica, Wells, Christopher, Philpott, Martin, Rogers, Catherine, Biggin, Philip C, Brennan, Paul E, Bunnage, Mark E, Schüle, Roland, Günther, Thomas, Knapp, Stefan, Müller, Susanne
Published in Science advances (01.11.2015)
Published in Science advances (01.11.2015)
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Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity
West, Clare E., Karim, Mohd, Falaguera, Maria J., Speidel, Leo, Green, Charlotte J., Logie, Lisa, Schwartzentruber, Jeremy, Ochoa, David, Lord, Janet M., Ferguson, Michael A. J., Bountra, Chas, Wilkinson, Graeme F., Vaughan, Beverley, Leach, Andrew R., Dunham, Ian, Marsden, Brian D.
Published in Scientific data (25.09.2023)
Published in Scientific data (25.09.2023)
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Journal Article
Use of the novel Contact Heat Evoked Potential Stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre counts
Atherton, Duncan D, Facer, Paul, Roberts, Katherine M, Misra, V Peter, Chizh, Boris A, Bountra, Chas, Anand, Praveen
Published in BMC neurology (03.08.2007)
Published in BMC neurology (03.08.2007)
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Open innovation in neuroscience research and drug discovery
Hunter, Ann J., Lee, Wen H., Bountra, Chas
Published in Brain and Neuroscience Advances (01.01.2018)
Published in Brain and Neuroscience Advances (01.01.2018)
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Book Review
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