RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation
Fontaine, Valérie, Boumedine, Thinhinane, Monteiro, Elodie, Fournié, Mylène, Gersende, Gendre, Sahel, José-Alain, Picaud, Serge, Veillet, Stanislas, Lafont, René, Latil, Mathilde, Dilda, Pierre J, Camelo, Serge
Published in International journal of molecular sciences (01.03.2024)
Published in International journal of molecular sciences (01.03.2024)
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Journal Article
Anti-Inflammatory Effects and Photo- and Neuro-Protective Properties of BIO203, a New Amide Conjugate of Norbixin, in Development for the Treatment of Age-Related Macular Degeneration (AMD)
Fontaine, Valérie, Balducci, Christine, Dinan, Laurence, Monteiro, Elodie, Boumedine, Thinhinane, Fournié, Mylène, Nguyen, Vincent, Guibout, Louis, Clatot, Justine, Latil, Mathilde, Veillet, Stanislas, Sahel, José-Alain, Lafont, René, Dilda, Pierre J, Camelo, Serge
Published in International journal of molecular sciences (01.03.2023)
Published in International journal of molecular sciences (01.03.2023)
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Journal Article
A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin
Fontaine, Valérie, Fournié, Mylène, Monteiro, Elodie, Boumedine, Thinhinane, Balducci, Christine, Guibout, Louis, Latil, Mathilde, Sahel, José-Alain, Veillet, Stanislas, Dilda, Pierre J, Lafont, René, Camelo, Serge
Published in Aging (Albany, NY.) (20.09.2021)
Published in Aging (Albany, NY.) (20.09.2021)
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Journal Article
In vitro and in vivo characterization of BIO203, a new amide norbixin conjugate with improved pharmacokinetic profile. Potential for oral treatment of age‐related retinal degeneration
Fontaine, Valérie, Camelo, Serge, Christine, Balducci, Laurence, Dinan, Monteiro, Elodie, Boumedine, Thinhinane, Nguyen, Vincent, Fournié, Mylene, Clatot, Justine, Latil, Mathilde, Veillet, Stanislas, Lafont, René, Dilda, Pierre
Published in Acta ophthalmologica (Oxford, England) (01.12.2022)
Published in Acta ophthalmologica (Oxford, England) (01.12.2022)
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Journal Article
Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease
Fontaine, Valérie, Monteiro, Elodie, Fournié, Mylène, Brazhnikova, Elena, Boumedine, Thinhinane, Vidal, Cécile, Balducci, Christine, Guibout, Louis, Latil, Mathilde, Dilda, Pierre J, Veillet, Stanislas, Sahel, José-Alain, Lafont, René, Camelo, Serge
Published in Aging (Albany, NY.) (07.04.2020)
Published in Aging (Albany, NY.) (07.04.2020)
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Journal Article
A2E induces the transactivation of RARs, PPARs and RXRs and its effects are counteracted by norbixin in retinal pigment epithelium cells in vitro
Fontaine, Valerie, Fournie, Mylène, Monteiro, Elodie, Boumedine, Thinhinane, Balducci, Christine, Guibout, Louis, Latil, Mathilde, Dilda, Pierre J, José Alain Sahel, Veillet, Stanislas, Lafont, René, Camelo, Serge
Published in bioRxiv (01.04.2020)
Published in bioRxiv (01.04.2020)
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