MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Coll, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B., Schroder, Kate
Published in Nature chemical biology (01.06.2019)
Published in Nature chemical biology (01.06.2019)
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Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
Santos, José Carlos, Boucher, Dave, Schneider, Larisa Kapinos, Demarco, Benjamin, Dilucca, Marisa, Shkarina, Kateryna, Heilig, Rosalie, Chen, Kaiwen W., Lim, Roderick Y. H., Broz, Petr
Published in Nature communications (24.06.2020)
Published in Nature communications (24.06.2020)
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Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
Boucher, Dave, Monteleone, Mercedes, Coll, Rebecca C, Chen, Kaiwen W, Ross, Connie M, Teo, Jessica L, Gomez, Guillermo A, Holley, Caroline L, Bierschenk, Damien, Stacey, Katryn J, Yap, Alpha S, Bezbradica, Jelena S, Schroder, Kate
Published in The Journal of experimental medicine (05.03.2018)
Published in The Journal of experimental medicine (05.03.2018)
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Journal Article
Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps
Chen, Kaiwen W, Monteleone, Mercedes, Boucher, Dave, Sollberger, Gabriel, Ramnath, Divya, Condon, Nicholas D, von Pein, Jessica B, Broz, Petr, Sweet, Matthew J, Schroder, Kate
Published in Science immunology (24.08.2018)
Published in Science immunology (24.08.2018)
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Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion
Monteleone, Mercedes, Stanley, Amanda C., Chen, Kaiwen W., Brown, Darren L., Bezbradica, Jelena S., von Pein, Jessica B., Holley, Caroline L., Boucher, Dave, Shakespear, Melanie R., Kapetanovic, Ronan, Rolfes, Verena, Sweet, Matthew J., Stow, Jennifer L., Schroder, Kate
Published in Cell reports (Cambridge) (07.08.2018)
Published in Cell reports (Cambridge) (07.08.2018)
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Journal Article
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5
Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B., Tanzer, Maria C., Monteleone, Mercedes, Robertson, Avril A. B., Cooper, Matthew A., Alvarez‐Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate, Masters, Seth L.
Published in European journal of immunology (01.10.2015)
Published in European journal of immunology (01.10.2015)
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Mathematical modelling of activation-induced heterogeneity in TNF, IL6, NOS2, and IL1β expression reveals cell state transitions underpinning macrophage responses to LPS
Dey, Shoumit, Boucher, Dave, Pitchford, Jon, Lagos, Dimitris
Published in Wellcome open research (01.07.2022)
Published in Wellcome open research (01.07.2022)
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Journal Article
Measuring Non-canonical Inflammasome Activation in Neutrophils
Monteleone, Mercedes, Boucher, Dave
Published in Methods in molecular biology (Clifton, N.J.) (2022)
Published in Methods in molecular biology (Clifton, N.J.) (2022)
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Gasdermin D Cleavage Assay Following Inflammasome Activation
Kamajaya, Louisa Janice, Boucher, Dave
Published in Methods in molecular biology (Clifton, N.J.) (2022)
Published in Methods in molecular biology (Clifton, N.J.) (2022)
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Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes
Ross, Connie, Chan, Amy H, von Pein, Jessica B, Maddugoda, Madhavi P, Boucher, Dave, Schroder, Kate
Published in Annual review of immunology (26.04.2022)
Published in Annual review of immunology (26.04.2022)
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Journal Article
Great balls of fire: activation and signalling of inflammatory caspases
Bateman, Georgia, Hill, Benjamin, Knight, Ryan, Boucher, Dave
Published in Biochemical Society transactions (30.06.2021)
Published in Biochemical Society transactions (30.06.2021)
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Extracorporeal Membrane Oxygenation-Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy
Amali, Aseervatham Anusha, Ravikumar, Sharada, Chew, Wei Leong, Tan, Zhaohong, Sam, Qi Hui, Chen, Kaiwen W, Boucher, Dave, MacLaren, Graeme, Chai, Louis Yi Ann
Published in Clinical infectious diseases (25.01.2024)
Published in Clinical infectious diseases (25.01.2024)
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