Affinity maturation of antibodies: optimized methods to generate high-quality ScFv libraries and isolate IgG candidates by high-throughput screening
Renaut, Laurence, Monnet, Céline, Dubreuil, Olivier, Zaki, Ouafa, Crozet, Fabien, Bouayadi, Khalil, Kharrat, Hakim, Mondon, Philippe
Published in Methods in molecular biology (Clifton, N.J.) (2012)
Published in Methods in molecular biology (Clifton, N.J.) (2012)
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Journal Article
Overexpression of DNA Polymerase β in Cell Results in a Mutator Phenotype and a Decreased Sensitivity to Anticancer Drugs
Canitrot, Yvan, Cazaux, Christophe, Frechet, Mathilde, Bouayadi, Khalil, Lesca, Claire, Salles, Bernard, Hoffmann, Jean-Sebastien
Published in Proceedings of the National Academy of Sciences - PNAS (13.10.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (13.10.1998)
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Combinatorial engineering to enhance thermostability of amylosucrase
Emond, Stéphane, André, Isabelle, Jaziri, Kais, Potocki‐Véronèse, Gabrielle, Mondon, Philippe, Bouayadi, Khalil, Kharrat, Hakim, Monsan, Pierre, Remaud‐Simeon, Magali
Published in Protein science (01.06.2008)
Published in Protein science (01.06.2008)
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A novel random mutagenesis approach using human mutagenic DNA polymerases to generate enzyme variant libraries
Emond, Stéphane, Mondon, Philippe, Pizzut-Serin, Sandra, Douchy, Laurent, Crozet, Fabien, Bouayadi, Khalil, Kharrat, Hakim, Potocki-Véronèse, Gabrielle, Monsan, Pierre, Remaud-Simeon, Magali
Published in Protein engineering, design and selection (01.04.2008)
Published in Protein engineering, design and selection (01.04.2008)
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Anti-HER3 Domain 1 and 3 Antibodies Reduce Tumor Growth by Hindering HER2/HER3 Dimerization and AKT-Induced MDM2, XIAP, and FoxO1 Phosphorylation
Lazrek, Yassamine, Dubreuil, Olivier, Garambois, Véronique, Gaborit, Nadège, Larbouret, Christel, Le Clorennec, Christophe, Thomas, Gaelle, Leconet, Wilhem, Jarlier, Marta, Pugnière, Martine, Vié, Nadia, Robert, Bruno, Monnet, Céline, Bouayadi, Khalil, Kharrat, Hakim, Mondon, Philippe, Pèlegrin, André, Chardès, Thierry
Published in Neoplasia (New York, N.Y.) (01.03.2013)
Published in Neoplasia (New York, N.Y.) (01.03.2013)
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Combined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody
Monnet, Céline, Jorieux, Sylvie, Souyris, Nathalie, Zaki, Ouafa, Jacquet, Alexandra, Fournier, Nathalie, Crozet, Fabien, de Romeuf, Christophe, Bouayadi, Khalil, Urbain, Rémi, Behrens, Christian K, Mondon, Philippe, Fontayne, Alexandre
Published in mAbs (01.03.2014)
Published in mAbs (01.03.2014)
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Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions
Monnet, Céline, Jorieux, Sylvie, Urbain, Rémi, Fournier, Nathalie, Bouayadi, Khalil, De Romeuf, Christophe, Behrens, Christian K, Fontayne, Alexandre, Mondon, Philippe
Published in Frontiers in immunology (04.02.2015)
Published in Frontiers in immunology (04.02.2015)
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Multiple mechanisms of resistance to cisplatin toxicity in an Escherichia coli K12 mutant
Salles, Bernard, Calsou, Patrick, Bouayadi, Khalil, Vinial, Hélène
Published in Toxicology (Amsterdam) (11.11.1994)
Published in Toxicology (Amsterdam) (11.11.1994)
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Human antibody libraries: a race to engineer and explore a larger diversity
Mondon, Philippe, Dubreuil, Olivier, Bouayadi, Khalil, Kharrat, Hakim
Published in Frontiers in bioscience (01.01.2008)
Published in Frontiers in bioscience (01.01.2008)
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Alternative-splicing-based bicistronic vectors for ratio-controlled protein expression and application to recombinant antibody production
Fallot, Stéphanie, Ben Naya, Raouia, Hieblot, Corinne, Mondon, Philippe, Lacazette, Eric, Bouayadi, Khalil, Kharrat, Abdelhakim, Touriol, Christian, Prats, Hervé
Published in Nucleic acids research (01.11.2009)
Published in Nucleic acids research (01.11.2009)
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A cytoplasmic protein–protein interaction detection method based on reporter translation
Renaut, Laurence, Bouayadi, Khalil, Kharrat, Hakim, Mondon, Philippe
Published in Analytical biochemistry (15.01.2009)
Published in Analytical biochemistry (15.01.2009)
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Optimized FC variants
JORIEUX SYLVIE, MONNET MARS CELINE, KHARRAT ABDELHAKIM, BOUAYADI KHALIL, BEHRENS CHRISTIAN, MONDON PHILIPPE
Year of Publication 20.12.2016
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Year of Publication 20.12.2016
Patent
Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and AKT-induced MDM2, XIAP, and FoxO1 phosphorylation: Anti-HER3 antibodies in cancer therapy
Lazrek, Yassamine, Dubreuil, Olivier, Garambois, Véronique, Gaborit, Nadège, Larbouret, Christel, Le Clorennec, Christophe, Thomas, Gaelle, Leconet, Wilhem, Jarlier, Marta, Pugnière, Martine, Vié, Nadia, Robert, Bruno, Monnet, Céline, Bouayadi, Khalil, Kharrat, Hakim, Mondon, Philippe, Pèlegrin, André, Chardès, Thierry
Published in Neoplasia (New York, N.Y.) (01.03.2013)
Published in Neoplasia (New York, N.Y.) (01.03.2013)
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Journal Article
Anti-HER3 Domain 1 and 3 Antibodies Reduce Tumor Growth by Hindering HER2/HER3 Dimerization and AKT-Induced MDM2, XIAP, and FoxO1 Phosphorylation12
Lazrek, Yassamine, Dubreuil, Olivier, Garambois, Véronique, Gaborit, Nadège, Larbouret, Christel, Le Clorennec, Christophe, Thomas, Gaelle, Leconet, Wilhem, Jarlier, Marta, Pugnière, Martine, Vié, Nadia, Robert, Bruno, Monnet, Céline, Bouayadi, Khalil, Kharrat, Hakim, Mondon, Philippe, Pèlegrin, André, Chardès, Thierry
Published in Neoplasia (New York, N.Y.) (01.03.2013)
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Published in Neoplasia (New York, N.Y.) (01.03.2013)
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OPTIMIZED FC VARIANTS
JORIEUX SYLVIE, MONNET MARS CELINE, KHARRAT ABDELHAKIM, BOUAYADI KHALIL, BEHRENS CHRISTIAN, MONDON PHILIPPE
Year of Publication 06.09.2016
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Year of Publication 06.09.2016
Patent
Method for generation of human hyperdiversified antibody fragment library
Mondon, Philippe, Souyris, Nathalie, Douchy, Laurent, Crozet, Fabien, Bouayadi, Khalil, Kharrat, Hakim
Published in Biotechnology journal (01.01.2007)
Published in Biotechnology journal (01.01.2007)
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Journal Article
Optimized and automated protocols for high-throughput screening of amylosucrase libraries
Emond, Stéphane, Potocki-Véronèse, Gabrielle, Mondon, Philippe, Bouayadi, Khalil, Kharrat, Hakim, Monsan, Pierre, Remaud-Simeon, Magali
Published in Journal of biomolecular screening (01.08.2007)
Published in Journal of biomolecular screening (01.08.2007)
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OPTIMIZED FC VARIANTS
JORIEUX SYLVIE, MONNET MARS CELINE, KHARRAT ABDELHAKIM, BOUAYADI KHALIL, BEHRENS CHRISTIAN, MONDON PHILIPPE
Year of Publication 30.11.2011
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Year of Publication 30.11.2011
Patent
Resistance to cisplatin in an E. coli B/r NalR mutant
Bouayadi, Khalil, Villani, Giuseppe, Salles, Bernard
Published in Mutation research. DNA repair (01.06.1993)
Published in Mutation research. DNA repair (01.06.1993)
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