Enhancing the stability and solubility of TEV protease using in silico design
Cabrita, Lisa D., Gilis, Dimitri, Robertson, Amy L., Dehouck, Yves, Rooman, Marianne, Bottomley, Stephen P.
Published in Protein science (01.11.2007)
Published in Protein science (01.11.2007)
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Journal Article
Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation
Robertson, Amy L, Headey, Stephen J, Saunders, Helen M, Ecroyd, Heath, Scanlon, Martin J, Carver, John A, Bottomley, Stephen P
Published in Proceedings of the National Academy of Sciences - PNAS (08.06.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (08.06.2010)
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Journal Article
Enhanced Molecular Mobility of Ordinarily Structured Regions Drives Polyglutamine Disease
Lupton, Christopher J., Steer, David L., Wintrode, Patrick L., Bottomley, Stephen P., Hughes, Victoria A., Ellisdon, Andrew M.
Published in The Journal of biological chemistry (02.10.2015)
Published in The Journal of biological chemistry (02.10.2015)
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Journal Article
The Z mutation alters the global structural dynamics of α1-antitrypsin
Hughes, Victoria A, Meklemburg, Robert, Bottomley, Stephen P, Wintrode, Patrick L
Published in PloS one (2014)
Published in PloS one (2014)
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Journal Article
Nucleocytoplasmic Coagulation: An Injury-Induced Aggregation Event that Disulfide Crosslinks Proteins and Facilitates Their Removal by Plasmin
Samson, Andre L., Knaupp, Anja S., Sashindranath, Maithili, Borg, Rachael J., Au, Amanda E.-L., Cops, Elisa J., Saunders, Helen M., Cody, Stephen H., McLean, Catriona A., Nowell, Cameron J., Hughes, Victoria A., Bottomley, Stephen P., Medcalf, Robert L.
Published in Cell reports (Cambridge) (25.10.2012)
Published in Cell reports (Cambridge) (25.10.2012)
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Journal Article
Smoothing a rugged protein folding landscape by sequence-based redesign
Porebski, Benjamin T., Keleher, Shani, Hollins, Jeffrey J., Nickson, Adrian A., Marijanovic, Emilia M., Borg, Natalie A., Costa, Mauricio G. S., Pearce, Mary A., Dai, Weiwen, Zhu, Liguang, Irving, James A., Hoke, David E., Kass, Itamar, Whisstock, James C., Bottomley, Stephen P., Webb, Geoffrey I., McGowan, Sheena, Buckle, Ashley M.
Published in Scientific reports (26.09.2016)
Published in Scientific reports (26.09.2016)
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Journal Article
The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates
Kennan, Ruth M, Wong, Wilson, Dhungyel, Om P, Han, Xiaoyan, Wong, David, Parker, Dane, Rosado, Carlos J, Law, Ruby H P, McGowan, Sheena, Reeve, Shane B, Levina, Vita, Powers, Glenn A, Pike, Robert N, Bottomley, Stephen P, Smith, A Ian, Marsh, Ian, Whittington, Richard J, Whisstock, James C, Porter, Corrine J, Rood, Julian I
Published in PLoS pathogens (01.11.2010)
Published in PLoS pathogens (01.11.2010)
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Journal Article
Conformational behavior and aggregation of ataxin-3 in SDS
Saunders, Helen M, Hughes, Victoria A, Cappai, Roberto, Bottomley, Stephen P
Published in PloS one (22.07.2013)
Published in PloS one (22.07.2013)
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Journal Article
The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes
Paxman, Jason J., Borg, Natalie A., Horne, James, Thompson, Philip E., Chin, Yanni, Sharma, Pooja, Simpson, Jamie S., Wielens, Jerome, Piek, Susannah, Kahler, Charlene M., Sakellaris, Harry, Pearce, Mary, Bottomley, Stephen P., Rossjohn, Jamie, Scanlon, Martin J.
Published in The Journal of biological chemistry (26.06.2009)
Published in The Journal of biological chemistry (26.06.2009)
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Journal Article
Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells
Samson, Andre L., Ho, Bosco, Au, Amanda E., Schoenwaelder, Simone M., Smyth, Mark J., Bottomley, Stephen P., Kleifeld, Oded, Medcalf, Robert L.
Published in Open biology (01.11.2016)
Published in Open biology (01.11.2016)
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Journal Article
DNA Accelerates the Inhibition of Human Cathepsin V by Serpins
Ong, Poh Chee, McGowan, Sheena, Pearce, Mary C., Irving, James A., Kan, Wan-Ting, Grigoryev, Sergei A., Turk, Boris, Silverman, Gary A., Brix, Klaudia, Bottomley, Stephen P., Whisstock, James C., Pike, Robert N.
Published in The Journal of biological chemistry (21.12.2007)
Published in The Journal of biological chemistry (21.12.2007)
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Journal Article
Crystal Structure of a UDP-glucose-specific Glycosyltransferase from a Mycobacterium Species
Fulton, Zara, McAlister, Adrian, Wilce, Matthew C.J., Brammananth, Rajini, Zaker-Tabrizi, Leyla, Perugini, Matthew A., Bottomley, Stephen P., Coppel, Ross L., Crellin, Paul K., Rossjohn, Jamie, Beddoe, Travis
Published in The Journal of biological chemistry (10.10.2008)
Published in The Journal of biological chemistry (10.10.2008)
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Journal Article
MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-κB Proinflammatory Responses
Verstak, Brett, Nagpal, Kamalpreet, Bottomley, Stephen P., Golenbock, Douglas T., Hertzog, Paul J., Mansell, Ashley
Published in The Journal of biological chemistry (04.09.2009)
Published in The Journal of biological chemistry (04.09.2009)
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Journal Article
The High Resolution Crystal Structure of the Human Tumor Suppressor Maspin Reveals a Novel Conformational Switch in the G-helix
Law, Ruby H.P., Irving, James A., Buckle, Ashley M., Ruzyla, Katya, Buzza, Marguerite, Bashtannyk-Puhalovich, Tanya A., Beddoe, Travis C., Nguyen, Kim, Worrall, D. Margaret, Bottomley, Stephen P., Bird, Phillip I., Rossjohn, Jamie, Whisstock, James C.
Published in The Journal of biological chemistry (10.06.2005)
Published in The Journal of biological chemistry (10.06.2005)
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Journal Article