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Published in Current opinion in chemical biology (01.10.2021)
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A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed
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Published in Cell reports (Cambridge) (01.12.2015)
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Optimizing human α-galactosidase for treatment of Fabry disease
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Dual Small-Molecule Targeting of Procaspase‑3 Dramatically Enhances Zymogen Activation and Anticancer Activity
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Published in Journal of the American Chemical Society (29.01.2014)
Published in Journal of the American Chemical Society (29.01.2014)
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Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients
Tonogai, Emily J, Huang, Shan, Botham, Rachel C, Berry, Matthew R, Joslyn, Stephen K, Daniel, Gregory B, Chen, Zixin, Rao, Jianghong, Zhang, Xiang, Basuli, Falguni, Rossmeisl, John H, Riggins, Gregory J, LeBlanc, Amy K, Fan, Timothy M, Hergenrother, Paul J
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Published in Neuro-oncology (Charlottesville, Va.) (01.10.2021)
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Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients
Joshi, Avadhut D, Botham, Rachel C, Schlein, Lisa J, Roth, Howard S, Mangraviti, Antonella, Borodovsky, Alexandra, Tyler, Betty, Joslyn, Steve, Looper, Jayme S, Podell, Michael, Fan, Timothy M, Hergenrother, Paul J, Riggins, Gregory J
Published in Oncotarget (06.10.2017)
Published in Oncotarget (06.10.2017)
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Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics
Roth, Howard S, Botham, Rachel C, Schmid, Steven C, Fan, Timothy M, Dirikolu, Levent, Hergenrother, Paul J
Published in Journal of medicinal chemistry (14.05.2015)
Published in Journal of medicinal chemistry (14.05.2015)
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Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis
Hergenrother, Paul J, Peterson, Quinn P, Goode, David R, West, Diana C, Botham, Rachel C
Published in Nature protocols (01.02.2010)
Published in Nature protocols (01.02.2010)
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Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1)
Hsu, Danny C, Roth, Howard S, West, Diana C, Botham, Rachel C, Novotny, Chris J, Schmid, Steven C, Hergenrother, Paul J
Published in ACS combinatorial science (09.01.2012)
Published in ACS combinatorial science (09.01.2012)
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HaloTag as a substrate-based macroautophagy reporter
Xiao, Qiang, Cruz, Gabrielle, Botham, Rachel, Fox, Susan G, Yu, Anan, Allen, Seth, Morimoto, Richard I, Kelly, Jeffery W
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2024)
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Engineering α-glucosidase to improve protein stability and cellular uptake for the potential treatment of Pompe disease
Botham, Rachel C., Hallows, William C., Reddy, Charu, Dellas, Nikki, Homan, David, Lao, Jessica, Zhu, Cynthia, Chng, Chinping, Sero, Antoinette, Miller, Matt, Choi, Su Jin, Sun, Baodong, McCluskie, Kerryn, Huisman, Gjalt, Silverman, Adam P.
Published in Molecular genetics and metabolism (01.02.2021)
Published in Molecular genetics and metabolism (01.02.2021)
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Engineering α-galactosidase A (GLA) to improve protein stability, efficacy and reduced immune response for the treatment of Fabry disease
Hallows, William Casey, Skvorak, Kristen, Zhu, Cynthia Yu, Sero, Antoinette, Botham, Rachel, Agard, Nicholas, Chng, Chinping, Dellas, Nikki, Miller, Matt, Shin, Jinsong, Viduya, Judy, Zhang, Xiyun, Schiffmann, Raphael, Huisman, Gjalt, McCluskie, Kerryn, Alaoui, Hicham
Published in Molecular genetics and metabolism (01.02.2020)
Published in Molecular genetics and metabolism (01.02.2020)
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Abstract 3620: An oral procaspase activating drug, PAC-1, shows preclinical promise for glioblastoma therapy
Joshi, Avadhut D., Botham, Rachel C., Roth, Howard S., Fan, Timothy M., Tarasow, Theodore M., Hergenrother, Paul J., Riggins, Gregory J.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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인간 알파-갈락토시다제 변이체
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Year of Publication 01.11.2022
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Year of Publication 01.11.2022
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조작된 산성 알파-글루코시다제 변이체
ZHU YU, HUISMAN GJALT W, VROOM JONATHAN, ALAOUI ISMAILI MOULAY HICHAM, HALLOWS WILLIAM CASEY, HOMAN DAVID WILLIAM, CHNG CHINPING, BOTHAM RACHEL CATHLEEN, DELLAS NIKKI, SILVERMAN ADAM P, LAO JESSICA P
Year of Publication 23.09.2022
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Year of Publication 23.09.2022
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인간 알파 갈락토시다제 변이체
ZHU YU, HUISMAN GJALT W, SERO ANTOINETTE, ALAOUI ISMAILI MOULAY HICHAM, HALLOWS WILLIAM CASEY, CHNG CHINPING, VIDUYA JUDY VICTORIA ANTONIO, VALLIEU KRISTEN JEAN, BOTHAM RACHEL CATHLEEN, DELLAS NIKKI
Year of Publication 30.08.2021
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Year of Publication 30.08.2021
Patent
Preparation of the Caspase-3/-7 substrate Ac-DEVD-pNA via Solution-Phase Peptide Synthesis
Peterson, Quinn P., Goode, David R., West, Diana C., Botham, Rachel C., Hergenrother, Paul J.
Published in Nature protocols (01.01.2010)
Published in Nature protocols (01.01.2010)
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