Identification of a Potential Antimalarial Drug Candidate from a Series of 2‑Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle
Le Manach, Claire, Nchinda, Aloysius T, Paquet, Tanya, Gonzàlez Cabrera, Diego, Younis, Yassir, Han, Ze, Bashyam, Sridevi, Zabiulla, Mohammed, Taylor, Dale, Lawrence, Nina, White, Karen L, Charman, Susan A, Waterson, David, Witty, Michael J, Wittlin, Sergio, Botha, Mariëtte E, Nondaba, Sindisiswe H, Reader, Janette, Birkholtz, Lyn-Marie, Jiménez-Díaz, María Belén, Martínez, María Santos, Ferrer, Santiago, Angulo-Barturen, Iñigo, Meister, Stephan, Antonova-Koch, Yevgeniya, Winzeler, Elizabeth A, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (10.11.2016)
Published in Journal of medicinal chemistry (10.11.2016)
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Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination
Reader, Janette, Botha, Mariëtte, Theron, Anjo, Lauterbach, Sonja B, Rossouw, Claire, Engelbrecht, Dewaldt, Wepener, Melanie, Smit, Annél, Leroy, Didier, Mancama, Dalu, Coetzer, Theresa L, Birkholtz, Lyn-Marie
Published in Malaria journal (22.05.2015)
Published in Malaria journal (22.05.2015)
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A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail
Burger, Pieter B, Williams, Marni, Sprenger, Janina, Reeksting, Shaun B, Botha, Mariëtte, Müller, Ingrid B, Joubert, Fourie, Birkholtz, Lyn-Marie, Louw, Abraham I
Published in Malaria journal (05.02.2015)
Published in Malaria journal (05.02.2015)
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Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
Paquet, Tanya, Le Manach, Claire, Cabrera, Diego González, Younis, Yassir, Henrich, Philipp P, Abraham, Tara S, Lee, Marcus C S, Basak, Rajshekhar, Ghidelli-Disse, Sonja, Lafuente-Monasterio, María José, Bantscheff, Marcus, Ruecker, Andrea, Blagborough, Andrew M, Zakutansky, Sara E, Zeeman, Anne-Marie, White, Karen L, Shackleford, David M, Mannila, Janne, Morizzi, Julia, Scheurer, Christian, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura María, Gamo, Francisco Javier, Reader, Janette, Botha, Mariette, Dechering, Koen J, Sauerwein, Robert W, Tungtaeng, Anchalee, Vanachayangkul, Pattaraporn, Lim, Chek Shik, Burrows, Jeremy, Witty, Michael J, Marsh, Kennan C, Bodenreider, Christophe, Rochford, Rosemary, Solapure, Suresh M, Jiménez-Díaz, María Belén, Wittlin, Sergio, Charman, Susan A, Donini, Cristina, Campo, Brice, Birkholtz, Lyn-Marie, Hanson, Kirsten K, Drewes, Gerard, Kocken, Clemens H M, Delves, Michael J, Leroy, Didier, Fidock, David A, Waterson, David, Street, Leslie J, Chibale, Kelly
Published in Science translational medicine (26.04.2017)
Published in Science translational medicine (26.04.2017)
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Antimalarial Pyrido[1,2‑a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model
Singh, Kawaljit, Okombo, John, Brunschwig, Christel, Ndubi, Ferdinand, Barnard, Linley, Wilkinson, Chad, Njogu, Peter M, Njoroge, Mathew, Laing, Lizahn, Machado, Marta, Prudêncio, Miguel, Reader, Janette, Botha, Mariette, Nondaba, Sindisiwe, Birkholtz, Lyn-Marie, Lauterbach, Sonja, Churchyard, Alisje, Coetzer, Theresa L, Burrows, Jeremy N, Yeates, Clive, Denti, Paolo, Wiesner, Lubbe, Egan, Timothy J, Wittlin, Sergio, Chibale, Kelly
Published in Journal of medicinal chemistry (23.02.2017)
Published in Journal of medicinal chemistry (23.02.2017)
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A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum -Infected Mouse Models from Structure–Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines
Le Manach, Claire, Paquet, Tanya, Brunschwig, Christel, Njoroge, Mathew, Han, Ze, Gonzàlez Cabrera, Diego, Bashyam, Sridevi, Dhinakaran, Rajkumar, Taylor, Dale, Reader, Janette, Botha, Mariette, Churchyard, Alisje, Lauterbach, Sonja, Coetzer, Theresa L, Birkholtz, Lyn-Marie, Meister, Stephan, Winzeler, Elizabeth A, Waterson, David, Witty, Michael J, Wittlin, Sergio, Jiménez-Díaz, María-Belén, Santos Martínez, María, Ferrer, Santiago, Angulo-Barturen, Iñigo, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (12.11.2015)
Published in Journal of medicinal chemistry (12.11.2015)
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Struikelblokke in kruislinguistiese en -kulturele pediatriese spraak-taalterapie en strategieë vir die bevordering van kultuurveilige praktyke: 'n omvangsbepaling
Botha, Mariëtte, Gerber, Berna, van der Merwe, Anita
Published in Litnet Akademies : 'n Joernaal vir die Geesteswetenskappe, Natuurwetenskappe, Regte en Godsdienswetenskappe (01.12.2021)
Published in Litnet Akademies : 'n Joernaal vir die Geesteswetenskappe, Natuurwetenskappe, Regte en Godsdienswetenskappe (01.12.2021)
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