Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors
Etsè, Koffi Sénam, Dorosz, Jerzy, McLain Christensen, Katrine, Thomas, Jean-Yves, Botez Pop, Iuliana, Goffin, Eric, Colson, Thomas, Lestage, Pierre, Danober, Laurence, Pirotte, Bernard, Kastrup, Jette Sandholm, Francotte, Pierre
Published in ACS chemical neuroscience (21.07.2021)
Published in ACS chemical neuroscience (21.07.2021)
Get full text
Journal Article
Web Resource
Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro‑2H‑1,2,4-benzothiadiazine 1,1-Dioxide Scaffold
Nørholm, Ann-Beth, Francotte, Pierre, Olsen, Lars, Krintel, Christian, Frydenvang, Karla, Goffin, Eric, Challal, Sylvie, Danober, Laurence, Botez-Pop, Iuliana, Lestage, Pierre, Pirotte, Bernard, Kastrup, Jette S
Published in Journal of medicinal chemistry (14.11.2013)
Published in Journal of medicinal chemistry (14.11.2013)
Get full text
Journal Article
Web Resource
Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces
Nørholm, Ann-Beth, Francotte, Pierre, Goffin, Eric, Botez, Iuliana, Danober, Laurence, Lestage, Pierre, Pirotte, Bernard, Kastrup, Jette S, Olsen, Lars, Oostenbrink, Chris
Published in Journal of chemical information and modeling (22.12.2014)
Published in Journal of chemical information and modeling (22.12.2014)
Get full text
Journal Article
Web Resource
Positive Allosteric Modulators of 2‑Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4‑Cyclopropyl-3,4-dihydro‑2H‑1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4‑Cyclopropyl-3,4-dihydro‑2H‑1,2,4-benzothiadiazine 1,1-Dioxides
Francotte, Pierre, Nørholm, Ann-Beth, Deva, Taru, Olsen, Lars, Frydenvang, Karla, Goffin, Eric, Fraikin, Pierre, de Tullio, Pascal, Challal, Sylvie, Thomas, Jean-Yves, Iop, Fabrice, Louis, Caroline, Botez-Pop, Iuliana, Lestage, Pierre, Danober, Laurence, Kastrup, Jette S, Pirotte, Bernard
Published in Journal of medicinal chemistry (26.11.2014)
Published in Journal of medicinal chemistry (26.11.2014)
Get full text
Journal Article
Web Resource
Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxide Scaffold
Nørholm, Ann-Beth, Francotte, Pierre, Olsen, Lars, Krintel, Christian, Frydenvang, Karla, Goffin, Eric, Challal, Sylvie, Danober, Laurence, Botez-Pop, Iuliana, Lestage, Pierre, Pirotte, Bernard, Kastrup, Jette S.
Published in Journal of medicinal chemistry (14.11.2013)
Published in Journal of medicinal chemistry (14.11.2013)
Get full text
Journal Article
Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2 H -1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxides
Francotte, Pierre, Nørholm, Ann-Beth, Deva, Taru, Olsen, Lars, Frydenvang, Karla, Goffin, Eric, Fraikin, Pierre, de Tullio, Pascal, Challal, Sylvie, Thomas, Jean-Yves, Iop, Fabrice, Louis, Caroline, Botez-Pop, Iuliana, Lestage, Pierre, Danober, Laurence, Kastrup, Jette S., Pirotte, Bernard
Published in Journal of medicinal chemistry (26.11.2014)
Published in Journal of medicinal chemistry (26.11.2014)
Get full text
Journal Article
5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis
Alvey, Luke Jonathan, De Ceuninck, Frédéric André, Deprez, Pierre Marc Marie Joseph, Amantini, David, Peixoto, Christophe, Brebion, Franck Laurent, Jary, Hélène Marie, Pop-Botez, Iuliana Ecaterina, Gosmini, Romain Luc Marie, Varin, Marie Laurence Claire
Year of Publication 08.08.2023
Get full text
Year of Publication 08.08.2023
Patent
5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
DE CEUNINCK, FREDERIC ANDRE, JARY, HELENE MARIE, VARIN, MARIE LAURENCE CLAIRE, AMANTINI, DAVID, POP-BOTEZ, IULIANA ECATERINA, GOSMINI, ROMAIN LUC MARIE, BREBION, FRANCK LAURENT, DEPREZ, PIERRE MARC MARIE JOSEPH, ALVEY, LUKE JONATHAN, PEIXOTO, CHRISTOPHE
Year of Publication 16.05.2023
Get full text
Year of Publication 16.05.2023
Patent
5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
POP-BOTEZ, Iuliana Ecaterina, DEPREZ, Pierre Marc Marie Joseph, DE CEUNINCK, Frédéric André, AMANTINI, David, BREBION, Franck Laurent, GOSMINI, Romain Luc Marie, VARIN, Marie Laurence Claire, ALVEY, Luke Jonathan, JARY, Helène Marie, PEIXOTO, Christophe
Year of Publication 30.03.2022
Get full text
Year of Publication 30.03.2022
Patent
5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
POP-BOTEZ, Iuliana Ecaterina, DEPREZ, Pierre Marc Marie Joseph, JARY, Hélène Marie, DE CEUNINCK, Frédéric André, AMANTINI, David, BREBION, Franck Laurent, GOSMINI, Romain Luc Marie, VARIN, Marie Laurence Claire, ALVEY, Luke Jonathan, PEIXOTO, Christophe
Year of Publication 07.10.2021
Get full text
Year of Publication 07.10.2021
Patent
5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as adamts inhibitors for the treatment of osteoarthritis
Pop-Botez, Iuliana, Alvey, Luke, De Ceuninck, Frédéric, Amantini, David, Peixoto, Christophe, Jary, Helène, Brebion, Franck, Deprez, Pierre, Gosmini, Romain, Varin, Marie
Year of Publication 28.08.2020
Get full text
Year of Publication 28.08.2020
Patent
5-[(piperazin-l-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis
Alvey, Luke Jonathan, De Ceuninck, Frédéric André, Deprez, Pierre Marc Marie Joseph, Amantini, David, Peixoto, Christophe, Brebion, Franck Laurent, Jary, Hélène Marie, Pop-Botez, Iuliana Ecaterina, Gosmini, Romain Luc Marie, Varin, Marie Laurence Claire
Year of Publication 09.03.2021
Get full text
Year of Publication 09.03.2021
Patent
5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS
BREBION, Franck, Laurent, DE CEUNINCK, Frédéric, André, ALVEY, Luke, Jonathan, VARIN, Marie, Laurence, Claire, AMANTINI, David, JARY, Hélène, LABÉGUÈRE, Frédéric, Gilbert, GOSMINI, Romain, Luc, Marie, DEPREZ, Pierre, Marc, Marie, Joseph, HENG, Rama, PEIXOTO, Christophe, POP-BOTEZ, Iuliana, Ecaterina
Year of Publication 06.01.2021
Get full text
Year of Publication 06.01.2021
Patent
5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
GOSMINI, Romain, VARIN, Marie, POP-BOTEZ, Iuliana, DEPREZ, Pierre, AMANTINI, David, JARY, Hélène, BREBION, Franck, De CEUNINCK, Frédéric, ALVEY, Luke, PEIXOTO, Christophe
Year of Publication 04.12.2019
Get full text
Year of Publication 04.12.2019
Patent
5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
DE CEUNINCK, Frederic, GOSMINI, Romain, VARIN, Marie, POP-BOTEZ, Iuliana, DEPREZ, Pierre, AMANTINI, David, BREBION, Franck, ALVEY, Luke, PEIXOTO, Christophe, JARY, Helene
Year of Publication 29.07.2019
Get full text
Year of Publication 29.07.2019
Patent
5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
POP-BOTEZ, Iuliana Ecaterina, DEPREZ, Pierre Marc Marie Joseph, JARY, Hélène Marie, DE CEUNINCK, Frédéric André, AMANTINI, David, BREBION, Franck Laurent, GOSMINI, Romain Luc Marie, VARIN, Marie Laurence Claire, ALVEY, Luke Jonathan, PEIXOTO, Christophe
Year of Publication 09.07.2020
Get full text
Year of Publication 09.07.2020
Patent
5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS
BREBION, Franck, Laurent, DE CEUNINCK, Frédéric, André, ALVEY, Luke, Jonathan, VARIN, Marie, Laurence, Claire, AMANTINI, David, JARY, Hélène, LABÉGUÈRE, Frédéric, Gilbert, GOSMINI, Romain, Luc, Marie, DEPREZ, Pierre, Marc, Marie, Joseph, HENG, Rama, PEIXOTO, Christophe, POP-BOTEZ, Iuliana, Ecaterina
Year of Publication 10.06.2020
Get full text
Year of Publication 10.06.2020
Patent
5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
GOSMINI, Romain, VARIN, Marie, POP-BOTEZ, Iuliana, DEPREZ, Pierre, JARY, Helène, AMANTINI, David, DE CEUNINCK, Frédéric, BREBION, Franck, ALVEY, Luke, PEIXOTO, Christophe
Year of Publication 25.03.2019
Get full text
Year of Publication 25.03.2019
Patent
5-[3-[piperzin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating E.G. osteoarthritis
De Ceuninck, Frédéric André, Alvey, Luke Jonathan, Deprez, Pierre Marc Marie Joseph, Labéguère, Frédéric Gilbert, Heng, Rama, Amantini, David, Peixoto, Christophe, Brebion, Franck Laurent, Jary, Hélène Marie, Pop-Botez, Iuliana Ecaterina, Gosmini, Romain Luc Marie, Varin, Marie Laurence Claire
Year of Publication 04.02.2020
Get full text
Year of Publication 04.02.2020
Patent
5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
POP-BOTEZ, Iuliana Ecaterina, DEPREZ, Pierre Marc Marie Joseph, DE CEUNINCK, Frédéric André, AMANTINI, David, BREBION, Franck Laurent, GOSMINI, Romain Luc Marie, VARIN, Marie Laurence Claire, ALVEY, Luke Jonathan, JARY, Helène Marie, PEIXOTO, Christophe
Year of Publication 20.01.2020
Get full text
Year of Publication 20.01.2020
Patent