Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1‑(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y1 Antagonist
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Biomarker Optimization to Track the Antithrombotic and Hemostatic Effects of Clopidogrel in Rats
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Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits
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Identification of 6‑Hydroxypyrimidin-4(1H)‑one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists
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Bird, Eileen, Tamura, James, Bostwick, Jeffrey S, Steinbacher, Thomas E, Stewart, Anne, Liu, Yizhi, Baumann, Jergen, Feyen, Jean, Tamasi, Joseph, Schumacher, William A
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Identification of 1-{2-[4-chloro-1 '-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4 '-piperidine]-1-yl] phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent
Jeon, Yoon T., Yang, Wu, Qiao, Jennifer X., Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C., Wang, Yufeng, Liu, Yajun, Clark, Charles G., Wong, Henry S., Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A., Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S., Schumacher, William A., Bostwick, Jeffrey S., Stewart, Anne B., Price, Laura A., Hua, Ji, Li, Danshi, Levesque, Paul C., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
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Wang, Tammy C., Qia, Jennifer X., Clark, Charles G., Jua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Everlof, Gerry, Schumacher, William A., Wong, Pancras C., Seiffert, Dietmar A., Stewart, Anne B., Bostwick, Jeffrey S., Crain, Earl J., Watson, Carol A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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Discovery of diarylurea P2Y1 antagonists with improved aqueous solubility
Wang, Tammy C., Qiao, Jennifer X., Clark, Charles G., Jua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Everlof, Gerry, Schumacher, William A., Wong, Pancras C., Seiffert, Dietmar A., Stewart, Anne B., Bostwick, Jeffrey S., Crain, Earl J., Watson, Carol A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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4-Benzothiazole-7-hydroxyindolinyl Diaryl Ureas Are Potent P2Y1 Antagonists with Favorable Pharmacokinetics: Low Clearance and Small Volume of Distribution
Qiao, Jennifer X., Wang, Tammy C., Hiebert, Sheldon, Hu, Carol H., Schumacher, William A., Spronk, Steven A., Clark, Charles G., Han, Ying, Hua, Ji, Price, Laura A., Shen, Hong, Chacko, Silvi A., Everlof, Gerry, Bostwick, Jeffrey S., Steinbacher, Thomas E., Li, Yi-Xin, Huang, Christine S., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
Published in ChemMedChem (01.10.2014)
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Inhibition of Repetitive Thrombus Formation in the Stenosed Canine Coronary Artery by Enoxaparin, But Not by Unfractionated Heparin
Leadley, Robert J, Kasiewski, Charles J, Bostwick, Jeffrey S, Bentley, Ross, Dunwiddie, Christopher T, Perrone, Mark H
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RPR120844, a novel, specific inhibitor of coagulation factor Xa inhibits venous thrombosis in the rabbit
Bostwick, J S, Bentley, R, Morgan, S, Brown, K, Chu, V, Ewing, W R, Spada, A P, Pauls, H, Perrone, M H, Dunwiddie, C T, Leadley, Jr, R J
Published in Thrombosis and haemostasis (01.01.1999)
Published in Thrombosis and haemostasis (01.01.1999)
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Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1-(2-(1 '-Neopentylspiro[indoline-3,4 '-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y(1) Antagonist
Qiao, Jennifer X., Wang, Tammy C., Ruel, Rejean, Thibeault, Carl, L'Heureux, Alexandre, Schumacher, William A., Spronk, Steven A., Hiebert, Sheldon, Bouthillier, Gilles, Lloyd, John, Pi, Zulan, Schnur, Dora M., Abell, Lynn M., Hua, Ji, Price, Laura A., Liu, Eddie, Wu, Qimin, Steinbacher, Thomas E., Bostwick, Jeffrey S., Chang, Ming, Zheng, Joanna, Gao, Qi, Ma, Baoqing, McDonnell, Patricia A., Huang, Christine S., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
Published in Journal of medicinal chemistry (28.11.2013)
Published in Journal of medicinal chemistry (28.11.2013)
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