Identification of IL12RB1 as a Novel Systemic Sclerosis Susceptibility Locus
López‐Isac, Elena, Bossini‐Castillo, Lara, Guerra, Sandra G., Denton, Christopher, Fonseca, Carmen, Assassi, Shervin, Zhou, Xiaodong, Mayes, Maureen D., Simeón, Carmen Pilar, Ortego‐Centeno, Norberto, Castellví, Iván, Carreira, Patricia, Gorlova, Olga, Beretta, Lorenzo, Santaniello, Alessandro, Lunardi, Claudio, Hesselstrand, Roger, Nordin, Annika, Riemekasten, Gabriela, Witte, Torsten, Hunzelmann, Nicolas, Kreuter, Alexander, Distler, Jörg H. W., Voskuyl, Alexandre E., Vries‐Bouwstra, Jeska, Koeleman, Bobby P., Herrick, Ariane, Worthington, Jane, Radstake, Timothy R. D. J., Martin, Javier
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.12.2014)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.12.2014)
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GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
López-Isac, Elena, Acosta-Herrera, Marialbert, Kerick, Martin, Assassi, Shervin, Satpathy, Ansuman T., Granja, Jeffrey, Mumbach, Maxwell R., Beretta, Lorenzo, Simeón, Carmen P., Carreira, Patricia, Ortego-Centeno, Norberto, Castellvi, Ivan, Bossini-Castillo, Lara, Carmona, F. David, Orozco, Gisela, Hunzelmann, Nicolas, Distler, Jörg H. W., Franke, Andre, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, de Vries-Bouwstra, Jeska, Wijmenga, Cisca, Koeleman, Bobby P. C., Nordin, Annika, Padyukov, Leonid, Hoffmann-Vold, Anna-Maria, Lie, Benedicte, Proudman, Susanna, Stevens, Wendy, Nikpour, Mandana, Vyse, Timothy, Herrick, Ariane L., Worthington, Jane, Denton, Christopher P., Allanore, Yannick, Brown, Matthew A., Radstake, Timothy R. D. J., Fonseca, Carmen, Chang, Howard Y., Mayes, Maureen D., Martin, Javier
Published in Nature communications (31.10.2019)
Published in Nature communications (31.10.2019)
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A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility
Carmona, F. David, Mackie, Sarah L., Martín, Jose-Ezequiel, Taylor, John C., Vaglio, Augusto, Eyre, Stephen, Bossini-Castillo, Lara, Castañeda, Santos, Cid, Maria C., Hernández-Rodríguez, José, Prieto-González, Sergio, Solans, Roser, Ramentol-Sintas, Marc, González-Escribano, M. Francisca, Ortiz-Fernández, Lourdes, Morado, Inmaculada C., Narváez, Javier, Miranda-Filloy, José A., Martínez-Berriochoa, Agustín, Unzurrunzaga, Ainhoa, Hidalgo-Conde, Ana, Madroñero-Vuelta, Ana B., Fernández-Nebro, Antonio, Ordóñez-Cañizares, M. Carmen, Escalante, Begoña, Marí-Alfonso, Begoña, Sopeña, Bernardo, Magro, César, Raya, Enrique, Grau, Elena, Román, José A., de Miguel, Eugenio, López-Longo, F. Javier, Martínez, Lina, Gómez-Vaquero, Carmen, Rodríguez-Rodríguez, Luis, Díaz-López, J. Bernardino, Caminal-Montero, Luis, Monfort, Jordi, Tío, Laura, Alegre-Sancho, Juan J., Sáez-Comet, Luis, Pérez-Conesa, Mercedes, Corbera-Bellalta, Marc, Fernández-Contreras, M. Encarnación, Sanchez-Pernaute, Olga, Blanco, Ricardo, Ortego-Centeno, Norberto, Ríos-Fernández, Raquel, Callejas, José L., Fanlo-Mateo, Patricia, Martínez-Taboada, Víctor M., Lunardi, Claudio, Cimmino, Marco A., Santilli, Daniele, Ramirez, Giuseppe A., Soriano, Alessandra, Muratore, Francesco, Pazzola, Giulia, Addimanda, Olga, Wijmenga, Cisca, Witte, Torsten, Schirmer, Jan H., Moosig, Frank, Franke, Andre, Molberg, Øyvind, Diamantopoulos, Andreas P., Carette, Simon, Cuthbertson, David, Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., McAlear, Carol A., Moreland, Larry, Monach, Paul A., Pagnoux, Christian, Seo, Philip, Spiera, Robert, Sreih, Antoine G., Ytterberg, Steven R., Gregersen, Peter K., Pease, Colin T., Gough, Andrew, Green, Michael, Hordon, Lesley, Jarrett, Stephen, Watts, Richard, Levy, Sarah, Patel, Yusuf, Kamath, Sanjeet, Dasgupta, Bhaskar, Worthington, Jane, Koeleman, Bobby P.C., de Bakker, Paul I.W., Barrett, Jennifer H., Merkel, Peter A., González-Gay, Miguel A., Morgan, Ann W., Martín, Javier
Published in American journal of human genetics (02.04.2015)
Published in American journal of human genetics (02.04.2015)
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Histone modifications underlie monocyte dysregulation in patients with systemic sclerosis, underlining the treatment potential of epigenetic targeting
van der Kroef, Maarten, Castellucci, Monica, Mokry, Michal, Cossu, Marta, Garonzi, Marianna, Bossini-Castillo, Lara M, Chouri, Eleni, Wichers, Catharina G K, Beretta, Lorenzo, Trombetta, Elena, Silva-Cardoso, Sandra, Vazirpanah, Nadia, Carvalheiro, Tiago, Angiolilli, Chiara, Bekker, Cornelis P J, Affandi, Alsya J, Reedquist, Kris A, Bonte-Mineur, Femke, Zirkzee, Els J M, Bazzoni, Flavia, Radstake, Timothy R D J, Rossato, Marzia
Published in Annals of the rheumatic diseases (01.04.2019)
Published in Annals of the rheumatic diseases (01.04.2019)
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Association of MicroRNA‐618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis
Rossato, Marzia, Affandi, Alsya J., Thordardottir, Soley, Wichers, Catharina G. K., Cossu, Marta, Broen, Jasper C. A., Moret, Frederique M., Bossini‐Castillo, Lara, Chouri, Eleni, van Bon, Lenny, Wolters, Femke, Marut, Wioleta, van der Kroef, Maarten, Silva‐Cardoso, Sandra, Bekker, Cornelis P. J., Dolstra, Harry, van Laar, Jacob M., Martin, Javier, van Roon, Joel A. G., Reedquist, Kris A., Beretta, Lorenzo, Radstake, Timothy R. D. J.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.09.2017)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.09.2017)
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Celiac Disease Is a Risk Factor for Mature T and NK Cell Lymphoma: A Mendelian Randomization Study
Martín-Masot, Rafael, Herrador-López, Marta, Navas-López, Víctor Manuel, Carmona, Francisco David, Nestares, Teresa, Bossini-Castillo, Lara
Published in International journal of molecular sciences (01.04.2023)
Published in International journal of molecular sciences (01.04.2023)
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Unraveling the genetic component of systemic sclerosis
Martin, Jose Ezequiel, Bossini-Castillo, Lara, Martin, Javier
Published in Human genetics (01.07.2012)
Published in Human genetics (01.07.2012)
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GNAI2 variants predict nonsteroidal anti‐inflammatory drug hypersensitivity in a genome‐wide study
Blanca, Miguel, Oussalah, Abderrahim, Cornejo‐García, José Antonio, Blanca‐López, Natalia, Guéant‐Rodriguez, Rosa‐Maria, Doña, Inmaculada, Mayorga, Cristobalina, Chery, Celine, Rouyer, Pierre, Carmona, Francisco David, Bossini Castillo, Lara, Canto, Gabriela, Martin, Javier, Torres, María José, Guéant, Jean‐Louis
Published in Allergy (Copenhagen) (01.05.2020)
Published in Allergy (Copenhagen) (01.05.2020)
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Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations
Gorlova, Olga Y, Li, Yafang, Gorlov, Ivan, Ying, Jun, Chen, Wei V, Assassi, Shervin, Reveille, John D, Arnett, Frank C, Zhou, Xiaodong, Bossini-Castillo, Lara, Lopez-Isac, Elena, Acosta-Herrera, Marialbert, Gregersen, Peter K, Lee, Annette T, Steen, Virginia D, Fessler, Barri J, Khanna, Dinesh, Schiopu, Elena, Silver, Richard M, Molitor, Jerry A, Furst, Daniel E, Kafaja, Suzanne, Simms, Robert W, Lafyatis, Robert A, Carreira, Patricia, Simeon, Carmen Pilar, Castellvi, Ivan, Beltran, Emma, Ortego, Norberto, Amos, Christopher I, Martin, Javier, Mayes, Maureen D
Published in PloS one (02.01.2018)
Published in PloS one (02.01.2018)
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Immune disease variants modulate gene expression in regulatory CD4+ T cells
Bossini-Castillo, Lara, Glinos, Dafni A., Kunowska, Natalia, Golda, Gosia, Lamikanra, Abigail A., Spitzer, Michaela, Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Cattermole, Claire, Alasoo, Kaur, Mann, Alice, Kundu, Kousik, Lorenc, Anna, Soranzo, Nicole, Dunham, Ian, Roberts, David J., Trynka, Gosia
Published in Cell genomics (13.04.2022)
Published in Cell genomics (13.04.2022)
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Analysis of ATP8B4 F436L Missense Variant in a Large Systemic Sclerosis Cohort
López‐Isac, Elena, Bossini‐Castillo, Lara, Palma, Ana B., Assassi, Shervin, Mayes, Maureen D., Simeón, Carmen P., Ortego‐Centeno, Norberto, Vicente, Esther, Tolosa, Carlos, Rubio‐Rivas, Manuel, Román‐Ivorra, José A., Beretta, Lorenzo, Moroncini, Gianluca, Hunzelmann, Nicolas, Distler, Jörg H. W., Riemekasten, Gabriella, de Vries‐Bouwstra, Jeska, Voskuyl, Alexandre E., Radstake, Timothy R. D. J., Herrick, Ariane, Denton, Christopher P., Fonseca, Carmen, Martín, Javier
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2017)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2017)
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Single Nucleotide Polymorphism Clustering in Systemic Autoimmune Diseases
Charlon, Thomas, Martínez-Bueno, Manuel, Bossini-Castillo, Lara, Carmona, F David, Di Cara, Alessandro, Wojcik, Jérôme, Voloshynovskiy, Sviatoslav, Martín, Javier, Alarcón-Riquelme, Marta E
Published in PloS one (04.08.2016)
Published in PloS one (04.08.2016)
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A multicenter study confirms CD226gene association with systemic sclerosis-related pulmonary fibrosis
Bossini-Castillo, Lara, Simeon, Carmen P, Beretta, Lorenzo, Broen, Jasper C, Vonk, Madelon C, Ríos-Fernández, Raquel, Espinosa, Gerard, Carreira, Patricia, Camps, María T, Castillo, Maria J, González-Gay, Miguel A, Beltrán, Emma, Carmen Freire, María del, Narváez, Javier, Tolosa, Carlos, Witte, Torsten, Kreuter, Alexander, Schuerwegh, Annemie J, Hoffmann-Vold, Anna-Maria, Hesselstrand, Roger, Lunardi, Claudio, van Laar, Jacob M, Chee, Meng May, Herrick, Ariane, Koeleman, Bobby PC, Denton, Christopher P, Fonseca, Carmen, Radstake, Timothy RDJ, Martin, Javier
Published in Arthritis research & therapy (24.04.2012)
Published in Arthritis research & therapy (24.04.2012)
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Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation
Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Ambridge, Kirsty, Ke, Ziying, Matte, Julie C., Bossini-Castillo, Lara, Kaplanis, Joanna, Ramirez-Navarro, Lucia, Lorenc, Anna, Nakic, Nikolina, Esparza-Gordillo, Jorge, Rowan, Wendy, Wille, David, Tough, David F., Bronson, Paola G., Trynka, Gosia
Published in Nature genetics (01.06.2022)
Published in Nature genetics (01.06.2022)
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Gene expression variability across cells and species shapes innate immunity
Hagai, Tzachi, Chen, Xi, Miragaia, Ricardo J., Rostom, Raghd, Gomes, Tomás, Kunowska, Natalia, Henriksson, Johan, Park, Jong-Eun, Proserpio, Valentina, Donati, Giacomo, Bossini-Castillo, Lara, Vieira Braga, Felipe A., Naamati, Guy, Fletcher, James, Stephenson, Emily, Vegh, Peter, Trynka, Gosia, Kondova, Ivanela, Dennis, Mike, Haniffa, Muzlifah, Nourmohammad, Armita, Lässig, Michael, Teichmann,Sarah A.
Published in Nature (London) (01.11.2018)
Published in Nature (London) (01.11.2018)
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Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases
Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Rowan, Wendy C., Nakic, Nikolina, Esparza-Gordillo, Jorge, Bossini-Castillo, Lara, Tough, David F., Larminie, Christopher G. C., Bronson, Paola G., Willé, David, Trynka, Gosia
Published in Nature genetics (01.10.2019)
Published in Nature genetics (01.10.2019)
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Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk
Pouget, Jennie G, Han, Buhm, Wu, Yang, Mignot, Emmanuel, Ollila, Hanna M, Barker, Jonathan, Spain, Sarah, Dand, Nick, Trembath, Richard, Martin, Javier, Mayes, Maureen D, Bossini-Castillo, Lara, López-Isac, Elena, Jin, Ying, Santorico, Stephanie A, Spritz, Richard A, Hakonarson, Hakon, Polychronakos, Constantin, Raychaudhuri, Soumya, Knight, Jo
Published in Human molecular genetics (15.10.2019)
Published in Human molecular genetics (15.10.2019)
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A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T reg cells
Nasrallah, Rabab, Imianowski, Charlotte J, Bossini-Castillo, Lara, Grant, Francis M, Dogan, Mikail, Placek, Lindsey, Kozhaya, Lina, Kuo, Paula, Sadiyah, Firas, Whiteside, Sarah K, Mumbach, Maxwell R, Glinos, Dafni, Vardaka, Panagiota, Whyte, Carly E, Lozano, Teresa, Fujita, Toshitsugu, Fujii, Hodaka, Liston, Adrian, Andrews, Simon, Cozzani, Adeline, Yang, Jie, Mitra, Suman, Lugli, Enrico, Chang, Howard Y, Unutmaz, Derya, Trynka, Gosia, Roychoudhuri, Rahul
Published in Nature (London) (16.07.2020)
Published in Nature (London) (16.07.2020)
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