Transcriptomic profiling of adjuvant colorectal cancer identifies three key prognostic biological processes and a disease specific role for granzyme B
Daemen, Anneleen, Udyavar, Akshata R, Sandmann, Thomas, Li, Congfen, Bosch, Linda J W, O'Gorman, William, Li, Yijin, Au-Yeung, Amelia, Takahashi, Chikara, Kabbarah, Omar, Bourgon, Richard, Hegde, Priti, Bais, Carlos, Das Thakur, Meghna
Published in PloS one (31.12.2021)
Published in PloS one (31.12.2021)
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Study protocol: Whole genome sequencing Implementation in standard Diagnostics for Every cancer patient (WIDE)
Samsom, Kris G, Bosch, Linda J W, Schipper, Luuk J, Roepman, Paul, de Bruijn, Ewart, Hoes, Louisa R, Riethorst, Immy, Schoenmaker, Lieke, van der Kolk, Lizet E, Retèl, Valesca P, Frederix, Geert W J, Buffart, Tineke E, van der Hoeven, Jacobus J M, Voest, Emile E, Cuppen, Edwin, Monkhorst, Kim, Meijer, Gerrit A
Published in BMC medical genomics (10.11.2020)
Published in BMC medical genomics (10.11.2020)
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Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer
Jacobsen, Annika, Bosch, Linda J. W., Martens-de Kemp, Sanne R., Carvalho, Beatriz, Sillars-Hardebol, Anke H., Dobson, Richard J., de Rinaldis, Emanuele, Meijer, Gerrit A., Abeln, Sanne, Heringa, Jaap, Fijneman, Remond J. A., Feenstra, K. Anton
Published in Scientific reports (14.05.2018)
Published in Scientific reports (14.05.2018)
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Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21
Derks, Sarah, Bosch, Linda J.W., Niessen, Hanneke E.C., Moerkerk, Peter T.M., van den Bosch, Sandra M., Carvalho, Beatriz, Mongera, Sandra, Voncken, J.Willem, Meijer, Gerrit A., de Bruïne, Adriaan P., Herman, James G., van Engeland, Manon
Published in Carcinogenesis (New York) (01.06.2009)
Published in Carcinogenesis (New York) (01.06.2009)
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Optimized whole-genome sequencing workflow for tumor diagnostics in routine pathology practice
Samsom, Kris G., Bosch, Linda J. W., Schipper, Luuk J., Schout, Daoin, Roepman, Paul, Boelens, Mirjam C., Lalezari, Ferry, Klompenhouwer, Elisabeth G., de Langen, Adrianus J., Buffart, Tineke E., van Linder, Berit M. H., van Deventer, Kelly, van den Burg, Kay, Unmehopa, Unga, Rosenberg, Efraim H., Koster, Roelof, Hogervorst, Frans B. L., van den Berg, José G., Riethorst, Immy, Schoenmaker, Lieke, van Beek, Daphne, de Bruijn, Ewart, van der Hoeven, Jacobus J. M., van Snellenberg, Hans, van der Kolk, Lizet E., Cuppen, Edwin, Voest, Emile E., Meijer, Gerrit A., Monkhorst, Kim
Published in Nature protocols (01.03.2024)
Published in Nature protocols (01.03.2024)
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Journal Article
Novel Stool-Based Protein Biomarkers for Improved Colorectal Cancer Screening: A Case-Control Study
Bosch, Linda J W, de Wit, Meike, Pham, Thang V, Coupé, Veerle M H, Hiemstra, Annemieke C, Piersma, Sander R, Oudgenoeg, Gideon, Scheffer, George L, Mongera, Sandra, Sive Droste, Jochim Terhaar, Oort, Frank A, van Turenhout, Sietze T, Larbi, Ilhame Ben, Louwagie, Joost, van Criekinge, Wim, van der Hulst, Rene W M, Mulder, Chris J J, Carvalho, Beatriz, Fijneman, Remond J A, Jimenez, Connie R, Meijer, Gerrit A
Published in Annals of internal medicine (19.12.2017)
Published in Annals of internal medicine (19.12.2017)
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Genomic landscape of metastatic colorectal cancer
Haan, Josien C., Labots, Mariette, Rausch, Christian, Koopman, Miriam, Tol, Jolien, Mekenkamp, Leonie J. M., van de Wiel, Mark A., Israeli, Danielle, van Essen, Hendrik F., van Grieken, Nicole C. T., Voorham, Quirinus J. M., Bosch, Linda J. W., Qu, Xueping, Kabbarah, Omar, Verheul, Henk M. W., Nagtegaal, Iris D., Punt, Cornelis J. A., Ylstra, Bauke, Meijer, Gerrit A.
Published in Nature communications (14.11.2014)
Published in Nature communications (14.11.2014)
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Journal Article
Clinical Impact of Prospective Whole Genome Sequencing in Sarcoma Patients
Schipper, Luuk J, Monkhorst, Kim, Samsom, Kris G, Bosch, Linda J W, Snaebjornsson, Petur, van Boven, Hester, Roepman, Paul, van der Kolk, Lizet E, van Houdt, Winan J, van der Graaf, Winette T A, Meijer, Gerrit A, Voest, Emile E
Published in Cancers (16.01.2022)
Published in Cancers (16.01.2022)
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Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial
Rozeman, Elisa A, Menzies, Alexander M, van Akkooi, Alexander C J, Adhikari, Chandra, Bierman, Carolien, van de Wiel, Bart A, Scolyer, Richard A, Krijgsman, Oscar, Sikorska, Karolina, Eriksson, Hanna, Broeks, Annegien, van Thienen, Johannes V, Guminski, Alexander D, Acosta, Alex Torres, ter Meulen, Sylvia, Koenen, Anne Miek, Bosch, Linda J W, Shannon, Kerwin, Pronk, Loes M, Gonzalez, Maria, Ch'ng, Sydney, Grijpink-Ongering, Lindsay G, Stretch, Jonathan, Heijmink, Stijn, van Tinteren, Harm, Haanen, John B A G, Nieweg, Omgo E, Klop, Willem M C, Zuur, Charlotte L, Saw, Robyn P M, van Houdt, Winan J, Peeper, Daniel S, Spillane, Andrew J, Hansson, Johan, Schumacher, Ton N, Long, Georgina V, Blank, Christian U
Published in The lancet oncology (01.07.2019)
Published in The lancet oncology (01.07.2019)
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Basic fibroblast growth factor-mediated overexpression of vascular endothelial growth factor in 1F6 human melanoma cells is regulated by activation of PI-3K and p38 MAPK
Fontijn, Dennis, Bosch, Linda J W, Duyndam, Monique C A, van Berkel, Maria P A, Janmaat, Maarten L, Boven, Epie
Published in Cellular oncology : the official journal of the International Society for Cellular Oncology (2009)
Published in Cellular oncology : the official journal of the International Society for Cellular Oncology (2009)
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IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma
Reijers, Irene L M, Rao, Disha, Versluis, Judith M, Menzies, Alexander M, Dimitriadis, Petros, Wouters, Michel W, Spillane, Andrew J, Klop, Willem M C, Broeks, Annegien, Bosch, Linda J W, Lopez-Yurda, Marta, van Houdt, Winan J, Rawson, Robert V, Grijpink-Ongering, Lindsay G, Gonzalez, Maria, Cornelissen, Sten, Bouwman, Jasper, Sanders, Joyce, Plasmeijer, Elsemieke, Elshot, Yannick S, Scolyer, Richard A, van de Wiel, Bart A, Peeper, Daniel S, van Akkooi, Alexander C J, Long, Georgina V, Blank, Christian U
Published in The Journal of experimental medicine (01.05.2023)
Published in The Journal of experimental medicine (01.05.2023)
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Journal Article
A Dysfunctional T-cell Gene Signature for Predicting Nonresponse to PD-1 Blockade in Non-small Cell Lung Cancer That Is Suitable for Routine Clinical Diagnostics
Hummelink, Karlijn, Tissier, Renaud, Bosch, Linda J W, Krijgsman, Oscar, van den Heuvel, Michel M, Theelen, Willemijn S M E, Damotte, Diane, Goldwasser, François, Leroy, Karen, Smit, Egbert F, Meijer, Gerrit A, Thommen, Daniela S, Monkhorst, Kim
Published in Clinical cancer research (16.02.2024)
Published in Clinical cancer research (16.02.2024)
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A phase 2 trial combining afatinib with cetuximab in patients with EGFR exon 20 insertion–positive non–small cell lung cancer
Veggel, Bianca A. M. H., Wekken, Anthonie J., Paats, Marthe S., Hendriks, Lizza E. L., Hashemi, Sayed M. S., Daletzakis, Antonios, Broek, Daan, Bosch, Linda J. W., Monkhorst, Kim, Smit, Egbert F., Langen, Adrianus J.
Published in Cancer (01.03.2024)
Published in Cancer (01.03.2024)
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Journal Article
Cost-effectiveness of High-performance Biomarker Tests vs Fecal Immunochemical Test for Noninvasive Colorectal Cancer Screening
Lansdorp-Vogelaar, Iris, Goede, S. Lucas, Bosch, Linda J.W., Melotte, Veerle, Carvalho, Beatriz, van Engeland, Manon, Meijer, Gerrit A., de Koning, Harry J., van Ballegooijen, Marjolein
Published in Clinical gastroenterology and hepatology (01.04.2018)
Published in Clinical gastroenterology and hepatology (01.04.2018)
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Impact of genetic counseling strategy on diagnostic yield and workload for genome-sequencing-based tumor diagnostics
Koster, Roelof, Schipper, Luuk J., Giesbertz, Noor A.A., van Beek, Daphne, Mendeville, Matías, Samsom, Kris G., Rosenberg, Efraim H., Hogervorst, Frans B.L., Roepman, Paul, Boelens, Mirjam C., Bosch, Linda J.W., van den Berg, Jose G., Meijer, Gerrit A., Voest, Emile E., Cuppen, Edwin, Ruijs, Marielle W.G., van Wezel, Tom, van der Kolk, Lizet, Monkhorst, Kim
Published in Genetics in medicine (01.02.2024)
Published in Genetics in medicine (01.02.2024)
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Proteins in stool as biomarkers for non‐invasive detection of colorectal adenomas with high risk of progression
Komor, Malgorzata A, Bosch, Linda JW, Coupé, Veerle MH, Rausch, Christian, Pham, Thang V, Piersma, Sander R, Mongera, Sandra, Mulder, Chris JJ, Dekker, Evelien, Kuipers, Ernst J, Wiel, Mark A, Carvalho, Beatriz, Fijneman, Remond JA, Jimenez, Connie R, Meijer, Gerrit A, Wit, Meike
Published in The Journal of pathology (01.03.2020)
Published in The Journal of pathology (01.03.2020)
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Feasibility of whole‐genome sequencing‐based tumor diagnostics in routine pathology practice
Samsom, Kris G, Schipper, Luuk J, Roepman, Paul, Bosch, Linda JW, Lalezari, Ferry, Klompenhouwer, Elisabeth G, Langen, Adrianus J, Buffart, Tineke E, Riethorst, Immy, Schoenmaker, Lieke, Schout, Daoin, Noort, Vincent, Berg, Jose G, Bruijn, Ewart, Hoeven, Jacobus JM, Snellenberg, Hans, Kolk, Lizet E, Cuppen, Edwin, Voest, Emile E, Meijer, Gerrit A, Monkhorst, Kim
Published in The Journal of pathology (01.10.2022)
Published in The Journal of pathology (01.10.2022)
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Journal Article
Cell-Free DNA at Diagnosis for Stage IV Non-Small Cell Lung Cancer: Costs, Time to Diagnosis and Clinical Relevance
Koole, Simone N, Vessies, Daan C L, Schuurbiers, Milou M F, Kramer, Astrid, Schouten, Robert D, Degeling, Koen, Bosch, Linda J W, van den Heuvel, Michel M, van Harten, Wim H, van den Broek, Daan, Monkhorst, Kim, Retèl, Valesca P
Published in Cancers (31.03.2022)
Published in Cancers (31.03.2022)
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Journal Article
WRN Promoter CpG Island Hypermethylation Does Not Predict More Favorable Outcomes for Patients with Metastatic Colorectal Cancer Treated with Irinotecan-Based Therapy
Bosch, Linda J W, Luo, Yanxin, Lao, Victoria V, Snaebjornsson, Petur, Trooskens, Geert, Vlassenbroeck, Ilse, Mongera, Sandra, Tang, Weiliang, Welcsh, Piri, Herman, James G, Koopman, Miriam, Nagtegaal, Iris D, Punt, Cornelis J A, van Criekinge, Wim, Meijer, Gerrit A, Monnat, Jr, Raymond J, Carvalho, Beatriz, Grady, William M
Published in Clinical cancer research (15.09.2016)
Published in Clinical cancer research (15.09.2016)
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Evaluation of Cancer-Associated DNA Copy Number Events in Colorectal (Advanced) Adenomas
Carvalho, Beatriz, Diosdado, Begoña, Terhaar Sive Droste, Jochim S, Bolijn, Anne S, Komor, Malgorzata A, de Wit, Meike, Bosch, Linda J W, van Burink, Myrthe, Dekker, Evelien, Kuipers, Ernst J, Coupé, Veerle M H, van Grieken, Nicole C T, Fijneman, Remond J A, Meijer, Gerrit A
Published in Cancer prevention research (Philadelphia, Pa.) (01.07.2018)
Published in Cancer prevention research (Philadelphia, Pa.) (01.07.2018)
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