Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox
Hermant, Paul, Bosc, Damien, Piveteau, Catherine, Gealageas, Ronan, Lam, BaoVy, Ronco, Cyril, Roignant, Matthieu, Tolojanahary, Hasina, Jean, Ludovic, Renard, Pierre-Yves, Lemdani, Mohamed, Bourotte, Marilyne, Herledan, Adrien, Bedart, Corentin, Biela, Alexandre, Leroux, Florence, Deprez, Benoit, Deprez-Poulain, Rebecca
Published in Journal of medicinal chemistry (09.11.2017)
Published in Journal of medicinal chemistry (09.11.2017)
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Journal Article
Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry
Deprez, Benoit, Bosc, Damien, Charton, Julie, Couturier, Cyril, Deprez-Poulain, Rebecca, Flipo, Marion, Leroux, Florence, Villemagne, Baptiste, Willand, Nicolas
Published in Molecules (Basel, Switzerland) (08.10.2021)
Published in Molecules (Basel, Switzerland) (08.10.2021)
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Journal Article
Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
Deprez-Poulain, Rebecca, Hennuyer, Nathalie, Bosc, Damien, Liang, Wenguang G, Enée, Emmanuelle, Marechal, Xavier, Charton, Julie, Totobenazara, Jane, Berte, Gonzague, Jahklal, Jouda, Verdelet, Tristan, Dumont, Julie, Dassonneville, Sandrine, Woitrain, Eloise, Gauriot, Marion, Paquet, Charlotte, Duplan, Isabelle, Hermant, Paul, Cantrelle, François-Xavier, Sevin, Emmanuel, Culot, Maxime, Landry, Valerie, Herledan, Adrien, Piveteau, Catherine, Lippens, Guy, Leroux, Florence, Tang, Wei-Jen, van Endert, Peter, Staels, Bart, Deprez, Benoit
Published in Nature communications (23.09.2015)
Published in Nature communications (23.09.2015)
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Journal Article
Modulators of hERAP2 discovered by high-throughput screening
Medve, Laura, Gealageas, Ronan, Lam, Bao Vy, Guillaume, Valentin, Castillo-Aguilera, Omar, Camberlein, Virgyl, Piveteau, Catherine, Rosell, Melissa, Fleau, Charlotte, Warenghem, Sandrine, Charton, Julie, Dumont-Ryckembusch, Julie, Bosc, Damien, Leroux, Florence, van Endert, Peter, Deprez, Benoit, Deprez-Poulain, Rebecca
Published in European journal of medicinal chemistry (05.02.2021)
Published in European journal of medicinal chemistry (05.02.2021)
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Journal Article
Structure–activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme
Charton, Julie, Gauriot, Marion, Totobenazara, Jane, Hennuyer, Nathalie, Dumont, Julie, Bosc, Damien, Marechal, Xavier, Elbakali, Jamal, Herledan, Adrien, Wen, Xiaoan, Ronco, Cyril, Gras-Masse, Helene, Heninot, Antoine, Pottiez, Virginie, Landry, Valerie, Staels, Bart, Liang, Wenguang G., Leroux, Florence, Tang, Wei-Jen, Deprez, Benoit, Deprez-Poulain, Rebecca
Published in European journal of medicinal chemistry (27.01.2015)
Published in European journal of medicinal chemistry (27.01.2015)
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Journal Article
Kinetic Target-Guided Synthesis: Reaching the Age of Maturity
Bosc, Damien, Camberlein, Virgyl, Gealageas, Ronan, Castillo-Aguilera, Omar, Deprez, Benoit, Deprez-Poulain, Rebecca
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Journal Article
Multi-component reaction for the preparation of 1,5-disubstituted 1,2,3-triazoles by in-situ generation of azides and nickel-catalyzed azide-alkyne cycloaddition
Camberlein, Virgyl, Kraupner, Nicolas, Bou Karroum, Nour, Lipka, Emmanuelle, Deprez-Poulain, Rebecca, Deprez, Benoit, Bosc, Damien
Published in Tetrahedron letters (08.06.2021)
Published in Tetrahedron letters (08.06.2021)
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Journal Article
Identification of indole-based activators of insulin degrading enzyme
Kraupner, Nicolas, Dinh, Chau Phi, Wen, Xiaoan, Landry, Valérie, Herledan, Adrien, Leroux, Florence, Bosc, Damien, Charton, Julie, Maillard, Clara, Warenghem, Sandrine, Duplan, Isabelle, Piveteau, Catherine, Hennuyer, Nathalie, Staels, Bart, Deprez, Benoit, Deprez-Poulain, Rebecca
Published in European journal of medicinal chemistry (15.01.2022)
Published in European journal of medicinal chemistry (15.01.2022)
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Journal Article
Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis
Camberlein, Virgyl, Fléau, Charlotte, Sierocki, Pierre, Li, Lenong, Gealageas, Ronan, Bosc, Damien, Guillaume, Valentin, Warenghem, Sandrine, Leroux, Florence, Rosell, Melissa, Cheng, Keguang, Medve, Laura, Prigent, Mathilde, Decanter, Myriam, Piveteau, Catherine, Biela, Alexandre, Eveque, Maxime, Dumont, Julie, Mpakali, Anastasia, Giastas, Petros, Herledan, Adrien, Couturier, Cyril, Haupenthal, Jörg, Lesire, Laetitia, Hirsch, Anna K. H., Deprez, Benoit, Stratikos, Efstratios, Bouvier, Marlene, Deprez‐Poulain, Rebecca
Published in Angewandte Chemie International Edition (26.09.2022)
Published in Angewandte Chemie International Edition (26.09.2022)
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Journal Article
Discovery of the First Selective Nanomolar Inhibitors of Endoplasmic Reticulum Aminopeptidase 2 by Kinetic Target‐Guided Synthesis
Camberlein, Virgyl, Fleau-Tabey, Charlotte, Sierocki, Pierre, Li, Lenong, Gealageas, Ronan, Bosc, Damien, Guillaume, Valentin, Warenghem, Sandrine, Leroux, Florence, Rosell, Melissa, Cheng, Keguang, Medve, Laura, Prigent, Mathilde, Decanter, Myriam, Piveteau, Catherine, Biela, Alexandre, Eveque, Maxime, Dumont, Julie, Mpakali, Anastasia, Giastas, Petros, Herledan, Adrien, Couturier, Cyril, Haupenthal, Jörg, Lesire, Laetitia, Hirsch, Anna, Deprez, Benoit, Stratikos, Efstratios, Bouvier, Marlene, Deprez-Poulain, Rebecca
Published in Angewandte Chemie International Edition (29.07.2022)
Published in Angewandte Chemie International Edition (29.07.2022)
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Journal Article
Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening
Leroux, Florence, Bosc, Damien, Beghyn, Terence, Hermant, Paul, Warenghem, Sandrine, Landry, Valérie, Pottiez, Virginie, Guillaume, Valentin, Charton, Julie, Herledan, Adrien, Urata, Sarah, Liang, Wenguang, Sheng, Li, Tang, Wei-Jen, Deprez, Benoit, Deprez-Poulain, Rebecca
Published in European journal of medicinal chemistry (01.10.2019)
Published in European journal of medicinal chemistry (01.10.2019)
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Journal Article
Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines
Regenass, Pierre, Bosc, Damien, Riché, Stéphanie, Gizzi, Patrick, Hibert, Marcel, Karmazin, Lydia, Ganesan, A., Bonnet, Dominique
Published in Journal of organic chemistry (2017)
Published in Journal of organic chemistry (2017)
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Journal Article
Development of fluorescent peptide substrates and assays for the key autophagy-initiating cysteine protease enzyme, ATG4B
Vezenkov, Lubomir, Honson, Nicolette S., Kumar, Nag S., Bosc, Damien, Kovacic, Suzana, Nguyen, Thanh G., Pfeifer, Tom A., Young, Robert N.
Published in Bioorganic & medicinal chemistry (01.07.2015)
Published in Bioorganic & medicinal chemistry (01.07.2015)
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Journal Article
Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines
Regenass, Pierre, Bosc, Damien, Riché, Stéphanie, Gizzi, Patrick, Hibert, Marcel, Karmazin, Lydia, Ganesan, A, Bonnet, Dominique
Published in Journal of organic chemistry (17.03.2017)
Published in Journal of organic chemistry (17.03.2017)
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Journal Article
New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis
Lethu, Sébastien, Bosc, Damien, Mouray, Elisabeth, Grellier, Philippe, Dubois, Joëlle
Published in Journal of enzyme inhibition and medicinal chemistry (01.02.2013)
Published in Journal of enzyme inhibition and medicinal chemistry (01.02.2013)
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Journal Article
Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors
Bosc, Damien, Mouray, Elisabeth, Cojean, Sandrine, Franco, Caio Haddad, Loiseau, Philippe M., Freitas-Junior, Lucio H., Moraes, Carolina Borsoi, Grellier, Philippe, Dubois, Joëlle
Published in European journal of medicinal chemistry (15.02.2016)
Published in European journal of medicinal chemistry (15.02.2016)
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Journal Article
Discovery of a New Class of Protein Farnesyltransferase Inhibitors in the Arylthiophene Series
Lethu, Sébastien, Ginisty, Maryon, Bosc, Damien, Dubois, Joëlle
Published in Journal of medicinal chemistry (22.10.2009)
Published in Journal of medicinal chemistry (22.10.2009)
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