NAD + cleavage activity by animal and plant TIR domains in cell death pathways
Horsefield, Shane, Burdett, Hayden, Zhang, Xiaoxiao, Manik, Mohammad K, Shi, Yun, Chen, Jian, Qi, Tiancong, Gilley, Jonathan, Lai, Jhih-Siang, Rank, Maxwell X, Casey, Lachlan W, Gu, Weixi, Ericsson, Daniel J, Foley, Gabriel, Hughes, Robert O, Bosanac, Todd, von Itzstein, Mark, Rathjen, John P, Nanson, Jeffrey D, Boden, Mikael, Dry, Ian B, Williams, Simon J, Staskawicz, Brian J, Coleman, Michael P, Ve, Thomas, Dodds, Peter N, Kobe, Bostjan
Published in Science (American Association for the Advancement of Science) (23.08.2019)
Published in Science (American Association for the Advancement of Science) (23.08.2019)
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Journal Article
Highly selective inhibition of Bruton's tyrosine kinase attenuates skin and brain disease in murine lupus
Chalmers, Samantha A, Wen, Jing, Doerner, Jessica, Stock, Ariel, Cuda, Carla M, Makinde, Hadijat M, Perlman, Harris, Bosanac, Todd, Webb, Deborah, Nabozny, Gerald, Fine, Jay S, Klein, Elliott, Ramanujam, Meera, Putterman, Chaim
Published in Arthritis research & therapy (25.01.2018)
Published in Arthritis research & therapy (25.01.2018)
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Journal Article
Evolution of the Total Synthesis of (−)-Okilactomycin Exploiting a Tandem Oxy-Cope Rearrangement/Oxidation, a Petasis−Ferrier Union/Rearrangement, and Ring-Closing Metathesis
Smith, Amos B, Bosanac, Todd, Basu, Kallol
Published in Journal of the American Chemical Society (18.02.2009)
Published in Journal of the American Chemical Society (18.02.2009)
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Journal Article
Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats
GINN, John D, BOSANAC, Todd, SCHLYER, Sabine, SMITH, James D, TURNER, Michael R, WU, Frank, YOUNG, Erick R. R, CHEN, Rhonda, CYWIN, Charles, HICKEY, Eugene, KASHEM, Mohammed, KERR, Steven, KUGLER, Stanley, XIANG LI, PROKOPOWICZ, Anthony
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate
Hughes, Robert O., Bosanac, Todd, Mao, Xianrong, Engber, Thomas M., DiAntonio, Aaron, Milbrandt, Jeffrey, Devraj, Rajesh, Krauss, Raul
Published in Cell reports (Cambridge) (05.01.2021)
Published in Cell reports (Cambridge) (05.01.2021)
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Journal Article
Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy
Bosanac, Todd, Hughes, Robert O, Engber, Thomas, Devraj, Rajesh, Brearley, Andrew, Danker, Kerstin, Young, Kenneth, Kopatz, Jens, Hermann, Melanie, Berthemy, Antoine, Boyce, Susan, Bentley, Jonathan, Krauss, Raul
Published in Brain (London, England : 1878) (29.11.2021)
Published in Brain (London, England : 1878) (29.11.2021)
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Journal Article
cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons
Sasaki, Yo, Engber, Thomas M., Hughes, Robert O., Figley, Matthew D., Wu, Tong, Bosanac, Todd, Devraj, Rajesh, Milbrandt, Jeffrey, Krauss, Raul, DiAntonio, Aaron
Published in Experimental neurology (01.07.2020)
Published in Experimental neurology (01.07.2020)
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Journal Article
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration
Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron, Ve, Thomas
Published in Neuron (Cambridge, Mass.) (07.04.2021)
Published in Neuron (Cambridge, Mass.) (07.04.2021)
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Journal Article
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules
Shi, Yun, Kerry, Philip S., Nanson, Jeffrey D., Bosanac, Todd, Sasaki, Yo, Krauss, Raul, Saikot, Forhad K., Adams, Sarah E., Mosaiab, Tamim, Masic, Veronika, Mao, Xianrong, Rose, Faith, Vasquez, Eduardo, Furrer, Marieke, Cunnea, Katie, Brearley, Andrew, Gu, Weixi, Luo, Zhenyao, Brillault, Lou, Landsberg, Michael J., DiAntonio, Aaron, Kobe, Bostjan, Milbrandt, Jeffrey, Hughes, Robert O., Ve, Thomas
Published in Molecular cell (05.05.2022)
Published in Molecular cell (05.05.2022)
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Journal Article
Kinase Crystal Miner: A Powerful Approach to Repurposing 3D Hinge Binding Fragments and Its Application to Finding Novel Bruton Tyrosine Kinase Inhibitors
Mukherjee, Prasenjit, Bentzien, Jörg, Bosanac, Todd, Mao, Wang, Burke, Michael, Muegge, Ingo
Published in Journal of chemical information and modeling (25.09.2017)
Published in Journal of chemical information and modeling (25.09.2017)
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Journal Article
The Novel, Clinical-Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease
Reinhart, Glenn A, Harrison, Paul C, Lincoln, Kathleen, Chen, Hongxing, Sun, Peng, Hill, Jon, Qian, Hu Sheng, McHugh, Mark C, Clifford, Holly, Ng, Khing Jow, Wang, Hong, Fowler, Danielle, Gueneva-Boucheva, Kristina, Brenneman, Jehrod B, Bosanac, Todd, Wong, Diane, Fryer, Ryan M, Sarko, Chris, Boustany-Kari, Carine M, Pullen, Steven S
Published in The Journal of pharmacology and experimental therapeutics (01.03.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2023)
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Journal Article
BTK inhibition ameliorates kidney disease in spontaneous lupus nephritis
Chalmers, Samantha A., Glynn, Elizabeth, Garcia, Sayra J., Panzenbeck, Mark, Pelletier, Josephine, Dimock, Janice, Seccareccia, Elise, Bosanac, Todd, Khalil, Sara, Harcken, Christian, Webb, Deborah, Nabozny, Gerald, Fine, Jay S., Souza, Donald, Klein, Elliott, Herlitz, Leal, Ramanujam, Meera, Putterman, Chaim
Published in Clinical immunology (Orlando, Fla.) (01.12.2018)
Published in Clinical immunology (Orlando, Fla.) (01.12.2018)
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Journal Article
Crystal and cryo-EM structures provide insight into how pro-neurodegenerative SARM1 is activated and cleaves NAD
Ve, Thomas, Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Cunnea, Katie, Kerry, Philip S., Bosanac, Todd, Hughes, Robert O., Kobe, Bostjan
Published in Acta crystallographica. Section A, Foundations and advances (14.08.2021)
Published in Acta crystallographica. Section A, Foundations and advances (14.08.2021)
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Journal Article
Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton's Tyrosine Kinase
Chalmers, Samantha A, Doerner, Jessica, Bosanac, Todd, Khalil, Sara, Smith, Dustin, Harcken, Christian, Dimock, Janice, Der, Evan, Herlitz, Leal, Webb, Deborah, Seccareccia, Elise, Feng, Di, Fine, Jay S, Ramanujam, Meera, Klein, Elliott, Putterman, Chaim
Published in Scientific reports (19.05.2016)
Published in Scientific reports (19.05.2016)
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Journal Article
A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat
Boustany-Kari, Carine M, Harrison, Paul C, Chen, Hongxing, Lincoln, Kathleen A, Qian, Hu Sheng, Clifford, Holly, Wang, Hong, Zhang, Xiaomei, Gueneva-Boucheva, Kristina, Bosanac, Todd, Wong, Diane, Fryer, Ryan M, Richman, Jeremy G, Sarko, Chris, Pullen, Steven S
Published in The Journal of pharmacology and experimental therapeutics (01.03.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2016)
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Journal Article
SARM1의 억제제
BOSANAC TODD, PARROTT SHELLEY ANNE, DEVRAJ RAJESH, JARJES PIKE RICHARD ANDREW, HUGHES ROBERT OWEN, BREARLEY ANDREW SIMON
Year of Publication 28.04.2023
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Year of Publication 28.04.2023
Patent
BTK inhibition ameliorates renal, skin, and brain disease in a spontaneous murine model of systemic lupus erythematosus
Chalmers, Samantha A., Wen, Jing, Doerner, Jessica L., Stock, Ariel D., Webb, Deborah, Herlitz, Leal, Bosanac, Todd, Nabozny, Gerald H., Fine, Jay S., Klein, Elliott, Ramanujam, Meera, Putterman, Chaim
Published in The Journal of immunology (1950) (01.05.2018)
Published in The Journal of immunology (1950) (01.05.2018)
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Journal Article
Total Synthesis of (−)-Okilactomycin
Smith, Amos B, Basu, Kallol, Bosanac, Todd
Published in Journal of the American Chemical Society (05.12.2007)
Published in Journal of the American Chemical Society (05.12.2007)
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Journal Article
신경보호를 위한 방법 및 조성물
BOSANAC TODD, DEVRAJ RAJESH, KRAUSS RAUL EDUARDO, LEVENTHAL LIZA, HUGHES ROBERT OWEN, AGRAWAL SUDHIR, ENGBER THOMAS, PASSINI MARCO A
Year of Publication 29.08.2022
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Year of Publication 29.08.2022
Patent