Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study
Pęcak, Paweł, Orzechowska, Beata, Chrobak, Elwira, Boryczka, Stanisław
Published in European journal of medicinal chemistry (05.12.2021)
Published in European journal of medicinal chemistry (05.12.2021)
Get full text
Journal Article
5,8-Quinolinedione Scaffold as a Promising Moiety of Bioactive Agents
Kadela-Tomanek, Monika, Bębenek, Ewa, Chrobak, Elwira, Boryczka, Stanisław
Published in Molecules (Basel, Switzerland) (14.11.2019)
Published in Molecules (Basel, Switzerland) (14.11.2019)
Get full text
Journal Article
Design, Synthesis and Biological Evaluation of Quinoline-8-Sulfonamides as Inhibitors of the Tumor Cell-Specific M2 Isoform of Pyruvate Kinase: Preliminary Study
Marciniec, Krzysztof, Rzepka, Zuzanna, Chrobak, Elwira, Boryczka, Stanisław, Latocha, Małgorzata, Wrześniok, Dorota, Beberok, Artur
Published in Molecules (Basel, Switzerland) (01.03.2023)
Published in Molecules (Basel, Switzerland) (01.03.2023)
Get full text
Journal Article
Lipophilicity, Pharmacokinetic Properties, and Molecular Docking Study on SARS-CoV-2 Target for Betulin Triazole Derivatives with Attached 1,4-Quinone
Kadela-Tomanek, Monika, Jastrzębska, Maria, Marciniec, Krzysztof, Chrobak, Elwira, Bębenek, Ewa, Boryczka, Stanisław
Published in Pharmaceutics (23.05.2021)
Published in Pharmaceutics (23.05.2021)
Get full text
Journal Article
The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study
Beberok, Artur, Rok, Jakub, Rzepka, Zuzanna, Marciniec, Krzysztof, Boryczka, Stanisław, Wrześniok, Dorota
Published in Toxicology in vitro (01.08.2020)
Published in Toxicology in vitro (01.08.2020)
Get full text
Journal Article
Novel Triazole Hybrids of Betulin: Synthesis and Biological Activity Profile
Bębenek, Ewa, Jastrzębska, Maria, Kadela-Tomanek, Monika, Chrobak, Elwira, Orzechowska, Beata, Zwolińska, Katarzyna, Latocha, Małgorzata, Mertas, Anna, Czuba, Zenon, Boryczka, Stanisław
Published in Molecules (Basel, Switzerland) (01.11.2017)
Published in Molecules (Basel, Switzerland) (01.11.2017)
Get full text
Journal Article
Interaction between moxifloxacin and Mcl-1 and MITF proteins: the effect on growth inhibition and apoptosis in MDA-MB-231 human triple-negative breast cancer cells
Beberok, Artur, Rok, Jakub, Rzepka, Zuzanna, Marciniec, Krzysztof, Boryczka, Stanisław, Wrześniok, Dorota
Published in Pharmacological reports (01.10.2022)
Published in Pharmacological reports (01.10.2022)
Get full text
Journal Article
Molecular Structure, In Vitro Anticancer Study and Molecular Docking of New Phosphate Derivatives of Betulin
Chrobak, Elwira, Jastrzębska, Maria, Bębenek, Ewa, Kadela-Tomanek, Monika, Marciniec, Krzysztof, Latocha, Małgorzata, Wrzalik, Roman, Kusz, Joachim, Boryczka, Stanisław
Published in Molecules (Basel, Switzerland) (31.01.2021)
Published in Molecules (Basel, Switzerland) (31.01.2021)
Get full text
Journal Article
The application of in silico experimental model in the assessment of ciprofloxacin and levofloxacin interaction with main SARS-CoV-2 targets: S-, E- and TMPRSS2 proteins, RNA-dependent RNA polymerase and papain-like protease (PLpro)—preliminary molecular docking analysis
Marciniec, Krzysztof, Beberok, Artur, Boryczka, Stanisław, Wrześniok, Dorota
Published in Pharmacological reports (01.12.2021)
Published in Pharmacological reports (01.12.2021)
Get full text
Journal Article
Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme
Kadela-Tomanek, Monika, Bębenek, Ewa, Chrobak, Elwira, Marciniec, Krzysztof, Latocha, Małgorzata, Kuśmierz, Dariusz, Jastrzębska, Maria, Boryczka, Stanisław
Published in European journal of medicinal chemistry (01.09.2019)
Published in European journal of medicinal chemistry (01.09.2019)
Get full text
Journal Article
Antiproliferative and Cytotoxic Properties of Propynoyl Betulin Derivatives against Human Ovarian Cancer Cells: In Vitro Studies
Chodurek, Ewa, Orchel, Arkadiusz, Gwiazdoń, Paweł, Kaps, Anna, Paduszyński, Piotr, Jaworska-Kik, Marzena, Chrobak, Elwira, Bębenek, Ewa, Boryczka, Stanisław, Kasperczyk, Janusz
Published in International journal of molecular sciences (01.11.2023)
Published in International journal of molecular sciences (01.11.2023)
Get full text
Journal Article
The Influence of Betulin and Its Derivatives EB5 and ECH147 on the Antioxidant Status of Human Renal Proximal Tubule Epithelial Cells
Kruszniewska-Rajs, Celina, Strzałka-Mrozik, Barbara, Kimsa-Dudek, Magdalena, Synowiec-Wojtarowicz, Agnieszka, Chrobak, Elwira, Bębenek, Ewa, Boryczka, Stanisław, Głuszek, Stanisław, Gola, Joanna Magdalena
Published in International journal of molecular sciences (25.02.2022)
Published in International journal of molecular sciences (25.02.2022)
Get full text
Journal Article
Anticancer Activity of the Acetylenic Derivative of Betulin Phosphate Involves Induction of Necrotic-Like Death in Breast Cancer Cells In Vitro
Orchel, Arkadiusz, Chodurek, Ewa, Jaworska-Kik, Marzena, Paduszyński, Piotr, Kaps, Anna, Chrobak, Elwira, Bębenek, Ewa, Boryczka, Stanisław, Borkowska, Paulina, Kasperczyk, Janusz
Published in Molecules (Basel, Switzerland) (25.01.2021)
Published in Molecules (Basel, Switzerland) (25.01.2021)
Get full text
Journal Article
Biological Activity and In Silico Study of 3-Modified Derivatives of Betulin and Betulinic Aldehyde
Bębenek, Ewa, Chrobak, Elwira, Marciniec, Krzysztof, Kadela-Tomanek, Monika, Trynda, Justyna, Wietrzyk, Joanna, Boryczka, Stanisław
Published in International journal of molecular sciences (19.03.2019)
Published in International journal of molecular sciences (19.03.2019)
Get full text
Journal Article
New Phosphorus Analogs of Bevirimat: Synthesis, Evaluation of Anti-HIV-1 Activity and Molecular Docking Study
Chrobak, Elwira, Marciniec, Krzysztof, Dąbrowska, Aleksandra, Pęcak, Paweł, Bębenek, Ewa, Kadela-Tomanek, Monika, Bak, Andrzej, Jastrzębska, Maria, Boryczka, Stanisław
Published in International journal of molecular sciences (21.10.2019)
Published in International journal of molecular sciences (21.10.2019)
Get full text
Journal Article
Acetylenic Synthetic Betulin Derivatives Inhibit Akt and Erk Kinases Activity, Trigger Apoptosis and Suppress Proliferation of Neuroblastoma and Rhabdomyosarcoma Cell Lines
Król, Sylwia K, Bębenek, Ewa, Dmoszyńska-Graniczka, Magdalena, Sławińska-Brych, Adrianna, Boryczka, Stanisław, Stepulak, Andrzej
Published in International journal of molecular sciences (14.11.2021)
Published in International journal of molecular sciences (14.11.2021)
Get full text
Journal Article