Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism
Lange, Jos H. M, Coolen, Hein K. A. C, van der Neut, Martina A. W, Borst, Alice J. M, Stork, Bob, Verveer, Peter C, Kruse, Chris G
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant: Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB1 Cannabinoid Receptor Antagonists
Lange, Jos H. M, van Stuivenberg, Herman H, Coolen, Hein K. A. C, Adolfs, Tiny J. P, McCreary, Andrew C, Keizer, Hiskias G, Wals, Henri C, Veerman, Willem, Borst, Alice J. M, de Looff, Wouter, Verveer, Peter C, Kruse, Chris G
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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N′-(Arylsulfonyl)pyrazoline-1-carboxamidines as Novel, Neutral 5-Hydroxytryptamine 6 Receptor (5-HT6R) Antagonists with Unique Structural Features
van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I, de Korte, Cor G, de Looff, Wouter, Verhoog, Stefan, van Wees, Jan-Willem, van Hoeve, Martijn, van de Woestijne, Rob P, van der Neut, Martina A. W, Borst, Alice J. M, van Dongen, Maria J. P, de Bruin, Natasja M. W. J, Keizer, Hiskias G, Kruse, Chris G
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies
LANGE, Jos H. M, VAN DER NEUT, Martina A. W, VAN VLIET, Bernard J, WALS, Henri C, KUIL, Gijs D, BORST, Alice J. M, MULDER, Arie, DEN HARTOG, Arnold P, ZILAOUT, Hicham, GOUTIER, Wouter, VAN STUIVENBERG, Herman H
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern
LANGE, Jos H. M, VAN DER NEUT, Martina A. W, BORST, Alice J. M, YILDIRIM, Mahmut, VAN STUIVENBERG, Herman H, VAN VLIET, Bernard J, KRUSE, Chris G
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB 1 Receptor Antagonism
Lange, Jos H. M., Coolen, Hein K. A. C., van der Neut, Martina A. W., Borst, Alice J. M., Stork, Bob, Verveer, Peter C., Kruse, Chris G.
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
Get full text
Journal Article
Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant: Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB 1 Cannabinoid Receptor Antagonists
Lange, Jos H. M., van Stuivenberg, Herman H., Coolen, Hein K. A. C., Adolfs, Tiny J. P., McCreary, Andrew C., Keizer, Hiskias G., Wals, Henri C., Veerman, Willem, Borst, Alice J. M., de Looff, Wouter, Verveer, Peter C., Kruse, Chris G.
Published in Journal of medicinal chemistry (01.03.2005)
Published in Journal of medicinal chemistry (01.03.2005)
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Journal Article
Probing the cannabinoid CB sub(1)/CB sub(2) receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern
Lange, Jos HM, Van der Neut, Martina AW, Borst, Alice JM, Yildirim, Mahmut, Van Stuivenberg, Herman H, Van Vliet, Bernard J, Kruse, Chris G
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB sub(2) receptor antagonists with high binding efficiencies
Lange, Jos HM, Van der Neut, Martina AW, Wals, Henri C, Kuil, Gijs D, Borst, Alice JM, Mulder, Arie, Hartog, Arnold Pden, Zilaout, Hicham, Goutier, Wouter, Van Stuivenberg, Herman H, Van Vliet, Bernard J
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article