CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
Choi, Bryan D., Yu, Xiaoling, Castano, Ana P., Bouffard, Amanda A., Schmidts, Andrea, Larson, Rebecca C., Bailey, Stefanie R., Boroughs, Angela C., Frigault, Matthew J., Leick, Mark B., Scarfò, Irene, Cetrulo, Curtis L., Demehri, Shadmehr, Nahed, Brian V., Cahill, Daniel P., Wakimoto, Hiroaki, Curry, William T., Carter, Bob S., Maus, Marcela V.
Published in Nature biotechnology (01.09.2019)
Published in Nature biotechnology (01.09.2019)
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A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq
Boroughs, Angela C., Larson, Rebecca C., Marjanovic, Nemanja D., Gosik, Kirk, Castano, Ana P., Porter, Caroline B.M., Lorrey, Selena J., Ashenberg, Orr, Jerby, Livnat, Hofree, Matan, Smith-Rosario, Gabriela, Morris, Robert, Gould, Joshua, Riley, Lauren S., Berger, Trisha R., Riesenfeld, Samantha J., Rozenblatt-Rosen, Orit, Choi, Bryan D., Regev, Aviv, Maus, Marcela V.
Published in Molecular therapy (02.12.2020)
Published in Molecular therapy (02.12.2020)
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Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells
Pourzia, Alexandra L., Olson, Michael L., Bailey, Stefanie R., Boroughs, Angela C., Aryal, Aditi, Ryan, Jeremy, Maus, Marcela V., Letai, Anthony
Published in Cell death & disease (13.04.2023)
Published in Cell death & disease (13.04.2023)
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Journal Article
Chimeric antigen receptor costimulation domains modulate human regulatory T cell function
Boroughs, Angela C, Larson, Rebecca C, Choi, Bryan D, Bouffard, Amanda A, Riley, Lauren S, Schiferle, Erik, Kulkarni, Anupriya S, Cetrulo, Curtis L, Ting, David, Blazar, Bruce R, Demehri, Shadmehr, Maus, Marcela V
Published in JCI insight (18.04.2019)
Published in JCI insight (18.04.2019)
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Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma
Schmidts, Andrea, Ormhøj, Maria, Choi, Bryan D., Taylor, Allison O., Bouffard, Amanda A., Scarfò, Irene, Larson, Rebecca C., Frigault, Matthew J., Gallagher, Kathleen, Castano, Ana P., Riley, Lauren S., Cabral, Maria L., Boroughs, Angela C., Velasco Cárdenas, Rubí M.-H., Schamel, Wolfgang, Zhou, Jing, Mackay, Sean, Tai, Yu-Tzu, Anderson, Kenneth C., Maus, Marcela V.
Published in Blood advances (12.11.2019)
Published in Blood advances (12.11.2019)
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TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation
Graham, Daniel B., Lefkovith, Ariel, Deelen, Patrick, de Klein, Niek, Varma, Mukund, Boroughs, Angela, Desch, A. Nicole, Ng, Aylwin C.Y., Guzman, Gaelen, Schenone, Monica, Petersen, Christine P., Bhan, Atul K., Rivas, Manuel A., Daly, Mark J., Carr, Steven A., Wijmenga, Cisca, Xavier, Ramnik J.
Published in Cell reports (Cambridge) (13.12.2016)
Published in Cell reports (Cambridge) (13.12.2016)
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Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources
Schmidts, Andrea, Marsh, Leah C, Srivastava, Ambike A, Bouffard, Amanda A, Boroughs, Angela C, Scarfò, Irene, Larson, Rebecca C, Bedoya, Felipe, Choi, Bryan D, Frigault, Matthew J, Bailey, Stefanie R, Leick, Mark B, Vatsa, Sonika, Kann, Michael C, Prew, Michelle S, Kleinstiver, Benjamin P, Joung, J Keith, Maus, Marcela V
Published in Journal for immunotherapy of cancer (01.09.2020)
Published in Journal for immunotherapy of cancer (01.09.2020)
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259 Discovery of synthetic signaling pathway receptors that increase the potency of CAR-T cells through optimized STAT activity
Gardner, Thomas J, Millare, Beatriz, Yao, Anzhi, Chen, Lan, Cass, Ashley, Mohanty, Suchismita, Chen, Jeremy, Gomez, Alma, DeTomaso, David, Ku, Manching, Berthoin, Lionel, Lim, Meng, Ong, Azalea, Thomas, Vince, Quant, Nicholas, Hsu, Brian, Casbon, Amy-Jo, Bezman, Natalie, Cooper, Aaron, Gray-Rupp, Levi, Boroughs, Angela, Nicholas Haining, W
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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301 Preclinical development of AB-2100, a PSMA neovasculature-inducible CA9 CAR resistant to FASL and TGFb mediated suppression for the treatment of ccRCC
Scarfo, Irene, Lim, Laura, Dang, Kevin, Chew, Marvin, Sudhakah, Rakesh, Nguyen, Michelle, Mohanty, Suchismita, Chen, Jeremy, Gomez, Alma, Attanasio, Nickolas, Fearon, Amanda, Chan, Ivan, Sail, Vibhavari, Gardner, Thomas J, Millare, Beatriz, Zhang, James, Moskowitz, Darrian, Thomas, Vince, Zhou, Stanley, Smith, Jenessa, McDevitt, Jennifer, Boroughs, Angela
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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213 AB-X integrated circuit T cells demonstrate improved potency, expansion, and specificity compared to MSLN CAR T cells
Santoro, Stephen, Cooper, Aaron, Bezman, Natalie, Feng, Jun, Chawla, Kanika, Williams, Jaspar, Gagnon, John, Hall, Jason, Polyak, Dina, Boroughs, Angela, Nguyen, Michelle, Mohanty, Suchismita, Litterman, Adam, Granja, Jeff, DeTomaso, David, Zheng, Grace, Smith, Jenessa, LeFace, Drake, Mikkelsen, Tarjei, Jun, Susie
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Development of AB-2100, an autologous integrated circuit T (ICT) cell therapy targeting CA9 intended for the treatment of ccRCC
Landon, Mark, Scarfo, Irene, Chew, Marvin, Sudhakah, Rakesh, Nguyen, Michelle, Mohanty, Suchismita, Chen, Jeremy, Gomez, Alma, Attanasio, Nickolas, Fearon, Amanda, Chan, Ivan, Sail, Vibhavari, Gardner, Thomas, Millare, Beatriz, Thomas, Vince, Zhou, Stanley, Smith, Jenessa, Mcdevitt, Jennifer, Boroughs, Angela, Gray-Rupp, Levi
Published in Journal of clinical oncology (01.02.2024)
Published in Journal of clinical oncology (01.02.2024)
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Journal Article
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions
Mohanan, Vishnu, Nakata, Toru, Desch, A Nicole, Lévesque, Chloé, Boroughs, Angela, Guzman, Gaelen, Cao, Zhifang, Creasey, Elizabeth, Yao, Junmei, Boucher, Gabrielle, Charron, Guy, Bhan, Atul K, Schenone, Monica, Carr, Steven A, Reinecker, Hans-Christian, Daly, Mark J, Rioux, John D, Lassen, Kara G, Xavier, Ramnik J
Published in Science (American Association for the Advancement of Science) (09.03.2018)
Published in Science (American Association for the Advancement of Science) (09.03.2018)
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Journal Article
Bispecific T-Cell Engager -Armored Chimeric Antigen Receptor T Cells Overcome Antigen Escape From EGFRvIII-Targeted Therapy For Glioblastoma
Choi, Bryan D, Yu, Xiaoling, Castano, Ana P, Bouffard, Amanda A, Schmidts, Andrea, Larson, Rebecca C, Bailey, Stefanie R, Boroughs, Angela C, Frigault, Matthew J, Leick, Mark B, Scarfo, Irene, Cetrulo, Curtis L, Demehri, Shadmehr, Nahed, Brian V, Cahill, Daniel P, Wakimoto, Hiroaki, Curry, William T, Carter, Bob S, Maus, Marcela V
Published in Neurosurgery (01.09.2019)
Published in Neurosurgery (01.09.2019)
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Journal Article
Abstract 4088: A neovasculature-inducible CA9 CAR resistant to FASL and TGFb mediated suppression for the treatment of ccRCC
Boroughs, Angela C., Scarfo, Irene, Attanasio, Nickolas, Gardner, Thomas, Smith, Jenessa B., McDevitt, Jennifer, Lim, Laura, Mehta, Nishant, Mohanty, Suchismita, Zhang, James, Cui, Eric, Sail, Vibhavari, Fearon, Amanda, Williams, Samuel, Santoro, Stephen, Haining, W. Nicholas, Gray-Rupp, Levi
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 38: AB-2100, a PSMA-inducible CA9-specific CAR T cell product for the treatment of ccRCC provides long-term tumor responses in preclinical mouse model
Mohanty, Suchismita, Chen, Jeremy, Gomez, Alma, Boroughs, Angela, Scarfo, Irene, Lim, Laura, Dang, Kevin, Chew, Marvin, Sudhakah, Rakesh, Nguyen, Michelle, Gardner, Thomas J., Millare, Beatriz, Zhang, James, Moskowitz, Darrian, Zhou, Stanley, Xie, Neroli H., Attanasio, Nickolas, Fearon, Amanda, Chan, Ivan, Sail, Vibhavari, Thomas, Vince, Smith, Jennesa, McDevitt, Jennifer, Gray-Rupp, Levi, Gonzalez, Alba, Murriel, Christopher, Haining, W. Nicholas
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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181 High throughput screening strategies in the development of logic gated cell therapies
Harari-Steinfeld, Rona, Lim, Laura, Boroughs, Angela, Panagiotopoulou, Sofia Kyriazopoulou, Cate, Sue, Thomas, Jamie, Chen, Jon, Cooper, Aaron, Fong, Ryan, Chua, Mary, Yashin, Ed, Shieh, Christine, Xu, Sophie, Haining, Nicholas
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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Journal Article
Abstract 2854: Logic gates controlled by priming receptors increase specificity and potency of CAR T cells
Williams, Jasper, Martinez, Kevin, Boroughs, Angela, Lim, Laura, Sandoval, Marian, Sue, Cate, Drever, Matthew, Yao, Anzhi, Choe, Joseph, Sidorov, Maxim, Phillips, Sophia, Polyak, Dina, Mohanty, Suchismita, Santoro, Stephen, Cooper, Aaron, Haining, W. Nicholas
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract 7034: Pooled CRISPR screening coupled with single-cell sequencing identifies modifiers of CAR T cell state in the context of chronic antigen stimulation
Joshi, Sahil, Wozniak, Glenn, Gagnon, John, Vucci, Kristina, Merrell, Allyson, Simon, Mandi, Oh, Catherine, Cardozo, Andrew, DeTomaso, David, Chow, Julie, Zheng, Grace, Boroughs, Angela, Joho, Keith, Thakore, Pratiksha, Oh, Soyoung, Freimer, Jake, Cass, Ashley, Sail, Vibhavari, Tocchini, Carla, Sandoval, Marian, Liu, Andrea, Cui, Eric, Drever, Matt, Galvin, Brendan, Milush, Jeff, Gray-Rupp, Levi, Wheeler, Emily, Chen, Bob, Levine, Jacob, Eidenschenk, Celine, Schartner, Jill, Geiger-Schuller, Katie, Huetter, Jan-Christian, Rutz, Sascha, Rozenblatt-Rosen, Orit, Mellman, Ira, Haining, W. Nicholas
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 7042: Enhancing TCR T cell function in solid tumors through in vivo combinatorial screens and single-cell analysis
Polyak, Dina, Fuhriman, Jessica, Susanto, Josephine, Merrell, Allyson, Simon, Mandi, Oh, Catherine, Cordazo, Andrew, DeTomasso, David, Tocchini, Carla, Sail, Vibhavari, Cui, Eric, Milush, Jeff, Gray-Rupp, Levi, Galvin, Brendan, Murriel, Christopher, Zheng, Grace, Boroughs, Angela C., Thakore, Pratiksha, Oh, Soyoung, Freimer, Jake, Chen, Bob, Eidenschenk, Celine, Wheeler, Emily, Levine, Jacob, Huetter, Jan-Christian, Schartner, Jill, Geiger-Schuller, Katie, Rozenblatt-Rosen, Orit, Rutz, Sascha, Mellman, Ira, Haining, W. Nicholas
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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