Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors
Haffner, Curt D, Becherer, J. David, Boros, Eric E, Cadilla, Rodolfo, Carpenter, Tiffany, Cowan, David, Deaton, David N, Guo, Yu, Harrington, Wallace, Henke, Brad R, Jeune, Michael R, Kaldor, Istvan, Milliken, Naphtali, Petrov, Kim G, Preugschat, Frank, Schulte, Christie, Shearer, Barry G, Shearer, Todd, Smalley, Terrence L, Stewart, Eugene L, Stuart, J. Darren, Ulrich, John C
Published in Journal of medicinal chemistry (23.04.2015)
Published in Journal of medicinal chemistry (23.04.2015)
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Discovery of a Highly Potent, Nonabsorbable Apical Sodium-Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes
Wu, Yulin, Aquino, Christopher J, Cowan, David J, Anderson, Don L, Ambroso, Jeff L, Bishop, Michael J, Boros, Eric E, Chen, Lihong, Cunningham, Alan, Dobbins, Robert L, Feldman, Paul L, Harston, Lindsey T, Kaldor, Istvan W, Klein, Ryan, Liang, Xi, McIntyre, Maggie S, Merrill, Christine L, Patterson, Kristin M, Prescott, Judith S, Ray, John S, Roller, Shane G, Yao, Xiaozhou, Young, Andrew, Yuen, Josephine, Collins, Jon L
Published in Journal of medicinal chemistry (27.06.2013)
Published in Journal of medicinal chemistry (27.06.2013)
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A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157
Preugschat, Frank, Carter, Luke H., Boros, Eric E., Porter, David J.T., Stewart, Eugene L., Shewchuk, Lisa M.
Published in Archives of biochemistry and biophysics (15.12.2014)
Published in Archives of biochemistry and biophysics (15.12.2014)
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Discovery of 4‑Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38
Becherer, J. David, Boros, Eric E., Carpenter, Tiffany Y., Cowan, David J., Deaton, David N., Haffner, Curt D., Jeune, Michael R., Kaldor, Istvan W., Poole, J. Chuck, Preugschat, Frank, Rheault, Tara R., Schulte, Christie A., Shearer, Barry G., Shearer, Todd W., Shewchuk, Lisa M., Smalley, Terrence L., Stewart, Eugene L., Stuart, J. Darren, Ulrich, John C.
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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Enzymatic- and Iridium-Catalyzed Asymmetric Synthesis of a Benzothiazepinylphosphonate Bile Acid Transporter Inhibitor
Cowan, David J., Collins, Jon L., Mitchell, Mark B., Ray, John A., Sutton, Peter W., Sarjeant, Amy A., Boros, Eric E.
Published in Journal of organic chemistry (20.12.2013)
Published in Journal of organic chemistry (20.12.2013)
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Inhibition of Tumor Necrosis Factor-induced Cell Death in MCF7 by a Novel Inhibitor of Neutral Sphingomyelinase
Luberto, Chiara, Hassler, Daniel F, Signorelli, Paola, Okamoto, Yasuo, Sawai, Hirofumi, Boros, Eric, Hazen-Martin, Debra J, Obeid, Lina M, Hannun, Yusuf A, Smith, Gary K
Published in The Journal of biological chemistry (25.10.2002)
Published in The Journal of biological chemistry (25.10.2002)
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The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral
GARVEY, Edward P, JOHNS, Brian A, WEATHERHEAD, Jason G, KOBLE, Cecilia S, ALIEN, Scott H, SCHALLER, Lee T, SHERRILL, Ronald G, YOSHINAGA, Tomokazu, KOBAYASHI, Masanori, WAKASA-MORIMOTO, Chiaki, MIKI, Shigeru, NAKAHARA, Koichiro, GARTLAND, Margaret J, NOSHI, Takeshi, SATO, Akihiko, FUJIWARA, Tamio, FOSTER, Scott A, MILLER, Wayne H, FERRIS, Robert G, HAZEN, Richard J, UNDERWOOD, Mark R, BOROS, Eric E, THOMPSON, James B
Published in Antimicrobial Agents and Chemotherapy (01.03.2008)
Published in Antimicrobial Agents and Chemotherapy (01.03.2008)
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Facile Reductive Amination of Aldehydes with Electron-Deficient Anilines by Acyloxyborohydrides in TFA: Application to a Diazaindoline Scale-Up
Boros, Eric E, Thompson, James B, Katamreddy, Subba R, Carpenter, Andrew J
Published in Journal of organic chemistry (01.05.2009)
Published in Journal of organic chemistry (01.05.2009)
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Naphthyridinone (NTD) integrase inhibitors: N1 Protio and methyl combination substituent effects with C3 amide groups
Johns, Brian A., Kawasuji, Takashi, Weatherhead, Jason G., Boros, Eric E., Thompson, James B., Koble, Cecilia S., Garvey, Edward P., Foster, Scott A., Jeffrey, Jerry L., Fujiwara, Tamio
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
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Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups
Johns, Brian A., Kawasuji, Takashi, Weatherhead, Jason G., Boros, Eric E., Thompson, James B., Koble, Cecilia S., Garvey, Edward P., Foster, Scott A., Jeffrey, Jerry L., Fujiwara, Tamio
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
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Discovery of 6,7-Dihydro‑5H‑pyrrolo[2,3‑a]pyrimidines as Orally Available G Protein-Coupled Receptor 119 Agonists
Katamreddy, Subba R, Carpenter, Andrew J, Ammala, Carina E, Boros, Eric E, Brashear, Ron L, Briscoe, Celia P, Bullard, Sarah R, Caldwell, Richard D, Conlee, Christopher R, Croom, Dallas K, Hart, Shane M, Heyer, Dennis O, Johnson, Paul R, Kashatus, Jennifer A, Minick, Doug J, Peckham, Gregory E, Ross, Sean A, Roller, Shane G, Samano, Vicente A, Sauls, Howard R, Tadepalli, Sarva M, Thompson, James B, Xu, Yun, Way, James M
Published in Journal of medicinal chemistry (27.12.2012)
Published in Journal of medicinal chemistry (27.12.2012)
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Development of Large-Scale Routes to Potent GPR119 Receptor Agonists
Matsuoka, Richard T, Boros, Eric E, Brown, Andrew D, Bullock, Kae M, Canoy, Will L, Carpenter, Andrew J, Cobb, Jeremy D, Condon, Shannon E, Deschamps, Nicole M, Elitzin, Vassil I, Erickson, Greg, Fang, Jing M, Igo, David H, Joshi, Biren K, Kaldor, Istvan W, Mitchell, Mark B, Peckham, Gregory E, Reynolds, Daniel W, Salmon, Matthew C, Sharp, Matthew J, Tabet, Elie A, Toczko, Jennifer F, Wu, Lianming Michael, Zhou, Xiao-ming M
Published in Organic process research & development (19.08.2016)
Published in Organic process research & development (19.08.2016)
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Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy[1,3]thiazolo[5,4- b]pyridin-5(4 H)-ones
Boros, Eric E., Johns, Brian A., Garvey, Edward P., Koble, Cecilia S., Miller, Wayne H.
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
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Journal Article
Synthesis and Antiviral Activity of 7-Benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV Integrase Inhibitors
Boros, Eric E, Edwards, Cynthia E, Foster, Scott A, Fuji, Masahiro, Fujiwara, Tamio, Garvey, Edward P, Golden, Pamela L, Hazen, Richard J, Jeffrey, Jerry L, Johns, Brian A, Kawasuji, Takashi, Kiyama, Ryuichi, Koble, Cecilia S, Kurose, Noriyuki, Miller, Wayne H, Mote, Angela L, Murai, Hitoshi, Sato, Akihiko, Thompson, James B, Woodward, Mark C, Yoshinaga, Tomokazu
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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Journal Article
Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors
Johns, Brian A., Kawasuji, Takashi, Weatherhead, Jason G., Boros, Eric E., Thompson, James B., Garvey, Edward P., Foster, Scott A., Jeffrey, Jerry L., Miller, Wayne H., Kurose, Noriyuki, Matsumura, Kenichi, Fujiwara, Tamio
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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Facile Reductive Amination of Aldehydes with Electron-Deficient Anilines by Acyloxyborohydrides in TFA: Application to a Diazaindoline Scale-Up
Boros, Eric E, Thompson, James B, Katamreddy, Subba R, Carpenter, Andrew J
Published in Journal of organic chemistry (20.11.2009)
Published in Journal of organic chemistry (20.11.2009)
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Journal Article
A Scaleable Synthesis of Methyl 3-Amino-5-(4-fluorobenzyl)-2-pyridinecarboxylate
Boros, Eric E, Burova, Svetlana A, Erickson, Greg A, Johns, Brian A, Koble, Cecilia S, Kurose, Noriyuki, Sharp, Matthew J, Tabet, Elie A, Thompson, James B, Toczko, Matthew A
Published in Organic process research & development (01.09.2007)
Published in Organic process research & development (01.09.2007)
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A scalable Nenitzescu synthesis of 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile
Boros, Eric E., Kaldor, Istvan, Turnbull, Philip S.
Published in Journal of heterocyclic chemistry (01.05.2011)
Published in Journal of heterocyclic chemistry (01.05.2011)
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