An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient
Quancard, Jean, Klein, Theo, Fung, Shan-Yu, Renatus, Martin, Hughes, Nicola, Israël, Laura, Priatel, John J, Kang, Sohyeong, Blank, Michael A, Viner, Rosa I, Blank, Jutta, Schlapbach, Achim, Erbel, Paul, Kizhakkedathu, Jayachandran, Villard, Frédéric, Hersperger, René, Turvey, Stuart E, Eder, Joerg, Bornancin, Frédéric, Overall, Christopher M
Published in Nature chemical biology (01.03.2019)
Published in Nature chemical biology (01.03.2019)
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Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation
Heiser, Diane, Rubert, Joëlle, Unterreiner, Adeline, Maurer, Claudine, Kamke, Marion, Bodendorf, Ursula, Farady, Christopher J, Roediger, Ben, Bornancin, Frédéric
Published in PloS one (12.11.2021)
Published in PloS one (12.11.2021)
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Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology
Martin, Kea, Junker, Ursula, Tritto, Elaine, Sutter, Esther, Rubic-Schneider, Tina, Morgan, Hannah, Niwa, Satoru, Li, Jianping, Schlapbach, Achim, Walker, Dana, Bigaud, Marc, Beerli, Christian, Littlewood-Evans, Amanda, Rudolph, Bettina, Laisney, Marc, Ledieu, David, Beltz, Karen, Quancard, Jean, Bornancin, Frédéric, Zamurovic Ribrioux, Natasa, Calzascia, Thomas
Published in Frontiers in immunology (30.04.2020)
Published in Frontiers in immunology (30.04.2020)
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Journal Article
Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation
Ginster, Stefanie, Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Renner, Florian, Lam, Stephen, Freuler, Felix, Gerrits, Bertran, Voshol, Johannes, Calzascia, Thomas, Régnier, Catherine H, Renatus, Martin, Nikolay, Rainer, Israël, Laura, Bornancin, Frédéric
Published in PloS one (04.01.2017)
Published in PloS one (04.01.2017)
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Journal Article
Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720
Zemann, Barbara, Kinzel, Bernd, Müller, Matthias, Reuschel, Roland, Mechtcheriakova, Diana, Urtz, Nicole, Bornancin, Frédéric, Baumruker, Thomas, Billich, Andreas
Published in Blood (15.02.2006)
Published in Blood (15.02.2006)
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FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood-Brain-Barrier Damage
Foster, Carolyn A., Mechtcheriakova, Diana, Storch, Maria K., Balatoni, Balázs, Howard, Laurence M., Bornancin, Frédéric, Wlachos, Alexander, Sobanov, Jury, Kinnunen, Anu, Baumruker, Thomas
Published in Brain pathology (Zurich, Switzerland) (01.04.2009)
Published in Brain pathology (Zurich, Switzerland) (01.04.2009)
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Journal Article
CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo
Israël, Laura, Glück, Anton, Berger, Marjorie, Coral, Marine, Ceci, Melanie, Unterreiner, Adeline, Rubert, Joëlle, Bardet, Maureen, Ginster, Stefanie, Golding-Ochsenbein, Alexandra M, Martin, Kea, Hoyler, Thomas, Calzascia, Thomas, Wieczorek, Grazyna, Hillenbrand, Rainer, Ferretti, Stéphane, Ferrero, Enrico, Bornancin, Frédéric
Published in Oncogenesis (New York, NY) (06.04.2021)
Published in Oncogenesis (New York, NY) (06.04.2021)
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Journal Article
Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β
Hommel, Ulrich, Hurth, Konstanze, Rondeau, Jean-Michel, Vulpetti, Anna, Ostermeier, Daniela, Boettcher, Andreas, Brady, Jacob Peter, Hediger, Michael, Lehmann, Sylvie, Koch, Elke, Blechschmidt, Anke, Yamamoto, Rina, Tundo Dottorello, Valentina, Haenni-Holzinger, Sandra, Kaiser, Christian, Lehr, Philipp, Lingel, Andreas, Mureddu, Luca, Schleberger, Christian, Blank, Jutta, Ramage, Paul, Freuler, Felix, Eder, Joerg, Bornancin, Frédéric
Published in Nature communications (07.09.2023)
Published in Nature communications (07.09.2023)
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Journal Article
Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates
Bell, Peter A., Scheuermann, Sophia, Renner, Florian, Pan, Christina L., Lu, Henry Y., Turvey, Stuart E., Bornancin, Frédéric, Régnier, Catherine H., Overall, Christopher M.
Published in Computational and structural biotechnology journal (01.01.2022)
Published in Computational and structural biotechnology journal (01.01.2022)
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Journal Article
Transcriptional repression of ceramide kinase in LPS-challenged macrophages
Rovina, Philipp, Jaritz, Markus, Bornancin, Frédéric
Published in Biochemical and biophysical research communications (08.10.2010)
Published in Biochemical and biophysical research communications (08.10.2010)
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Journal Article
Ceramide Kinase Profiling by Mass Spectrometry Reveals a Conserved Phosphorylation Pattern Downstream of the Catalytic Site
Chen, Wei-Qiang, Graf, Christine, Zimmel, David, Rovina, Philipp, Krapfenbauer, Kurt, Jaritz, Markus, Parker, Peter J, Lubec, Gert, Bornancin, Frédéric
Published in Journal of proteome research (04.01.2010)
Published in Journal of proteome research (04.01.2010)
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Journal Article
The role of sphingosine and ceramide kinases in inflammatory responses
Baumruker, Thomas, Bornancin, Frédéric, Billich, Andreas
Published in Immunology letters (31.01.2005)
Published in Immunology letters (31.01.2005)
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Journal Article
Characterization of a ceramide kinase-like protein
Bornancin, Frédéric, Mechtcheriakova, Diana, Stora, Samantha, Graf, Christine, Wlachos, Alexander, Dévay, Piroska, Urtz, Nicole, Baumruker, Thomas, Billich, Andreas
Published in Biochimica et biophysica acta (21.02.2005)
Published in Biochimica et biophysica acta (21.02.2005)
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Journal Article
Effects of ceramide-1-phosphate on cultured cells: dependence on dodecane in the vehicle
Tauzin, Loïc, Graf, Christine, Sun, Mei, Rovina, Philipp, Bouveyron, Nicolas, Jaritz, Markus, Winiski, Anthony, Hartmann, Nicole, Staedtler, Frank, Billich, Andreas, Baumruker, Thomas, Zhang, Mei, Bornancin, Frédéric
Published in Journal of lipid research (2007)
Published in Journal of lipid research (2007)
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Journal Article
Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood
Quancard, Jean, Simic, Oliver, Pissot Soldermann, Carole, Aichholz, Reiner, Blatter, Markus, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Endres, Ralf, Sorge, Mickael, Kieffer, Laurence, Wagner, Trixie, Beltz, Karen, Mcsheehy, Paul, Wartmann, Markus, Régnier, Catherine H, Calzascia, Thomas, Radimerski, Thomas, Bigaud, Marc, Weiss, Andreas, Bornancin, Frédéric, Schlapbach, Achim
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Journal Article
A critical β6–β7 loop in the pleckstrin homology domain of ceramide kinase
Rovina, Philipp, Jaritz, Markus, Höfinger, Siegfried, Graf, Christine, Dévay, Piroska, Billich, Andreas, Baumruker, Thomas, Bornancin, Frédéric
Published in Biochemical journal (01.12.2006)
Published in Biochemical journal (01.12.2006)
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