Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract
Zhang, Jianan, Walker, Morgan E., Sanidad, Katherine Z., Zhang, Hongna, Liang, Yanshan, Zhao, Ermin, Chacon-Vargas, Katherine, Yeliseyev, Vladimir, Parsonnet, Julie, Haggerty, Thomas D., Wang, Guangqiang, Simpson, Joshua B., Jariwala, Parth B., Beaty, Violet V., Yang, Jun, Yang, Haixia, Panigrahy, Anand, Minter, Lisa M., Kim, Daeyoung, Gibbons, John G., Liu, LinShu, Li, Zhengze, Xiao, Hang, Borlandelli, Valentina, Overkleeft, Hermen S., Cloer, Erica W., Major, Michael B., Goldfarb, Dennis, Cai, Zongwei, Redinbo, Matthew R., Zhang, Guodong
Published in Nature communications (10.01.2022)
Published in Nature communications (10.01.2022)
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Journal Article
Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate
Simpson, Joshua B., Sekela, Josh J., Graboski, Amanda L., Borlandelli, Valentina B., Bivins, Marissa M., Barker, Natalie K., Sorgen, Alicia A., Mordant, Angie L., Johnson, Rebecca L., Bhatt, Aadra P., Fodor, Anthony A., Herring, Laura E., Overkleeft, Hermen, Lee, John R., Redinbo, Matthew. R.
Published in Gut microbes (31.12.2022)
Published in Gut microbes (31.12.2022)
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Journal Article
Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity
Graboski, Amanda L, Simpson, Joshua B, Pellock, Samuel J, Mehta, Naimee, Creekmore, Benjamin C, Ariyarathna, Yamuna, Bhatt, Aadra P, Jariwala, Parth B, Sekela, Josh J, Kowalewski, Mark E, Barker, Natalie K, Mordant, Angie L, Borlandelli, Valentina B, Overkleeft, Hermen, Herring, Laura E, Jin, Jian, I James, Lindsey, Redinbo, Matthew R
Published in RSC chemical biology (28.08.2024)
Published in RSC chemical biology (28.08.2024)
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Journal Article
Fast Cyclization of a Proline‐Derived Self‐Immolative Spacer Improves the Efficacy of Carbamate Prodrugs
Dal Corso, Alberto, Borlandelli, Valentina, Corno, Cristina, Perego, Paola, Belvisi, Laura, Pignataro, Luca, Gennari, Cesare
Published in Angewandte Chemie International Edition (02.03.2020)
Published in Angewandte Chemie International Edition (02.03.2020)
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Journal Article
Rapid, Potent, and Persistent Covalent Chemical Probes to Deconvolute PI3Kα Signaling
Bissegger, Lukas, Constantin, Theodora Alexandra Alexandra, Keles, Erhan, Raguž, Luka, Barlow-Busch, Isobel, Orbegozo, Clara, Schaefer, Thorsten, Borlandelli, Valentina, Bohnacker, Thomas, SriRamaratnam, Rohitha, Schäfer, Alexander, Gstaiger, Matthias, Burke, John E., Borsari, Chiara, Wymann, Matthias
Published in Chemical science (Cambridge) (2024)
Published in Chemical science (Cambridge) (2024)
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Human milk oligosaccharide 2’-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice
Paone, Paola, Latousakis, Dimitris, Terrasi, Romano, Vertommen, Didier, Jian, Ching, Borlandelli, Valentina, Suriano, Francesco, Johansson, Malin E V, Puel, Anthony, Bouzin, Caroline, Delzenne, Nathalie M, Salonen, Anne, Juge, Nathalie, Florea, Bogdan I, Muccioli, Giulio G, Overkleeft, Herman, Van Hul, Matthias, Cani, Patrice D
Published in Gut (01.10.2024)
Published in Gut (01.10.2024)
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Journal Article
β‑l-Arabinofurano-cyclitol Aziridines Are Covalent Broad-Spectrum Inhibitors and Activity-Based Probes for Retaining β‑l‑Arabinofuranosidases
Borlandelli, Valentina, Offen, Wendy, Moroz, Olga, Nin-Hill, Alba, McGregor, Nicholas, Binkhorst, Lars, Ishiwata, Akihiro, Armstrong, Zachary, Artola, Marta, Rovira, Carme, Davies, Gideon J., Overkleeft, Herman S.
Published in ACS chemical biology (15.12.2023)
Published in ACS chemical biology (15.12.2023)
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Journal Article
β-l- Arabino furano-cyclitol Aziridines Are Covalent Broad-Spectrum Inhibitors and Activity-Based Probes for Retaining β-l-Arabinofuranosidases
Borlandelli, Valentina, Offen, Wendy, Moroz, Olga, Nin-Hill, Alba, McGregor, Nicholas, Binkhorst, Lars, Ishiwata, Akihiro, Armstrong, Zachary, Artola, Marta, Rovira, Carme, Davies, Gideon J, Overkleeft, Herman S
Published in ACS chemical biology (15.12.2023)
Published in ACS chemical biology (15.12.2023)
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Journal Article
Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β‐l‐Arabinofuranosidase Inhibitor
McGregor, Nicholas G. S., Coines, Joan, Borlandelli, Valentina, Amaki, Satoko, Artola, Marta, Nin‐Hill, Alba, Linzel, Daniël, Yamada, Chihaya, Arakawa, Takatoshi, Ishiwata, Akihiro, Ito, Yukishige, Marel, Gijsbert A., Codée, Jeroen D. C., Fushinobu, Shinya, Overkleeft, Herman S., Rovira, Carme, Davies, Gideon J.
Published in Angewandte Chemie International Edition (08.03.2021)
Published in Angewandte Chemie International Edition (08.03.2021)
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Journal Article
Selective labelling of GBA2 in cells with fluorescent β-d-arabinofuranosyl cyclitol aziridines
Su, Qin, Louwerse, Max, Lammers, Rob F, Maurits, Elmer, Janssen, Max, Boot, Rolf G, Borlandelli, Valentina, Offen, Wendy A, Linzel, Daniël, Schröder, Sybrin P, Davies, Gideon J, Overkleeft, Herman S, Artola, Marta, Aerts, Johannes M F G
Published in Chemical science (Cambridge) (03.09.2024)
Published in Chemical science (Cambridge) (03.09.2024)
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Journal Article
Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics
Simpson, Joshua B., Walker, Morgan E., Sekela, Joshua J., Ivey, Samantha M., Jariwala, Parth B., Storch, Cameron M., Kowalewski, Mark E., Graboski, Amanda L., Lietzan, Adam D., Walton, William G., Davis, Kacey A., Cloer, Erica W., Borlandelli, Valentina, Hsiao, Yun-Chung, Roberts, Lee R., Perlman, David H., Liang, Xue, Overkleeft, Hermen S., Bhatt, Aadra P., Lu, Kun, Redinbo, Matthew R.
Published in Cell host & microbe (12.06.2024)
Published in Cell host & microbe (12.06.2024)
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Journal Article
4‐O‐Substituted Glucuronic Cyclophellitols are Selective Mechanism‐Based Heparanase Inhibitors
Borlandelli, Valentina, Armstrong, Zachary, Nin‐Hill, Alba, Codée, Jeroen D. C., Raich, Lluís, Artola, Marta, Rovira, Carme, Davies, Gideon J., Overkleeft, Herman S.
Published in ChemMedChem (14.02.2023)
Published in ChemMedChem (14.02.2023)
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Journal Article
Fast Cyclization of a Proline‐Derived Self‐Immolative Spacer Improves the Efficacy of Carbamate Prodrugs
Dal Corso, Alberto, Borlandelli, Valentina, Corno, Cristina, Perego, Paola, Belvisi, Laura, Pignataro, Luca, Gennari, Cesare
Published in Angewandte Chemie (02.03.2020)
Published in Angewandte Chemie (02.03.2020)
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Journal Article
Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β‐l‐Arabinofuranosidase Inhibitor
McGregor, Nicholas G. S., Coines, Joan, Borlandelli, Valentina, Amaki, Satoko, Artola, Marta, Nin‐Hill, Alba, Linzel, Daniël, Yamada, Chihaya, Arakawa, Takatoshi, Ishiwata, Akihiro, Ito, Yukishige, Marel, Gijsbert A., Codée, Jeroen D. C., Fushinobu, Shinya, Overkleeft, Herman S., Rovira, Carme, Davies, Gideon J.
Published in Angewandte Chemie (08.03.2021)
Published in Angewandte Chemie (08.03.2021)
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Journal Article
PSEUDO-DISACCHARIDE COMPOUNDS
DE BOER, Casper, DAVIES, Gideon, BORLANDELLI, Valentina, LIT, Vincent, OVERKLEEFT, Herman, SCHRÖDER, Sybrin, WU, Liang
Year of Publication 02.11.2023
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Year of Publication 02.11.2023
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