Abstract CT-01: BYL719, a next generation PI3K alpha specific inhibitor: Preliminary safety, PK, and efficacy results from the first-in-human study
Juric, Dejan, Rodon, Jordi, Gonzalez-Angulo, Ana M., Burris, Howard A., Bendell, Johanna, Berlin, Jordan D., Middleton, Mark R., Bootle, Douglas, Boehm, Markus, Schmitt, Antonin, Rouyrre, Nicolas, Quadt, Cornelia, Baselga, Jose
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Phase I and Pharmacokinetic Study of the Polyamine Synthesis Inhibitor SAM486A in Combination with 5-Fluorouracil/ Leucovorin in Metastatic Colorectal Cancer
VAN ZUYLEN, Lia, BRIDGEWATER, John, LEDERMANN, Jonathan A, VERWEIJ, Jaap, SPARREBOOM, Alex, ESKENS, Ferry A. L. M, DE BRUIJN, Peter, SKLENAR, Ivo, PLANTING, Andre S. T, CHOI, Les, BOOTLE, Douglas, MUELLER, Christian
Published in Clinical cancer research (15.03.2004)
Published in Clinical cancer research (15.03.2004)
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Alpelisib Plus Fulvestrant in PIK3CA-Altered and PIK3CA-Wild-Type Estrogen Receptor-Positive Advanced Breast Cancer: A Phase 1b Clinical Trial
Juric, Dejan, Janku, Filip, Rodón, Jordi, Burris, Howard A, Mayer, Ingrid A, Schuler, Martin, Seggewiss-Bernhardt, Ruth, Gil-Martin, Marta, Middleton, Mark R, Baselga, José, Bootle, Douglas, Demanse, David, Blumenstein, Lars, Schumacher, Karl, Huang, Alan, Quadt, Cornelia, Rugo, Hope S
Published in JAMA oncology (01.02.2019)
Published in JAMA oncology (01.02.2019)
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A phase Ib study of the combination of naporafenib with rineterkib or trametinib in patients with advanced and metastatic KRAS- or BRAF-mutant non-small cell lung cancer
Planchard, David, Wolf, Jürgen, Solomon, Benjamin, Sebastian, Martin, Wermke, Martin, Heist, Rebecca S., Sun, Jong-Mu, Min Kim, Tae, Reguart, Noemi, Sanmamed, Miguel F., Felip, Enriqueta, Garrido, Pilar, Santoro, Armando, Bootle, Douglas, Couillebault, Xuân-Mai, Gaur, Anil, Mueller, Christina, Poggio, Teresa, Yang, Jie, Moschetta, Michele, Dooms, Christophe
Published in Lung cancer (Amsterdam, Netherlands) (01.11.2024)
Published in Lung cancer (Amsterdam, Netherlands) (01.11.2024)
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Population pharmacokinetics and pharmacodynamics of BYL719, a phosphoinositide 3‐kinase antagonist, in adult patients with advanced solid malignancies
De Buck, Stefan S., Jakab, Annamaria, Boehm, Markus, Bootle, Douglas, Juric, Dejan, Quadt, Cornelia, Goggin, Timothy K.
Published in British journal of clinical pharmacology (01.09.2014)
Published in British journal of clinical pharmacology (01.09.2014)
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A Phase 1b/2 Study of Alpelisib in Combination with Cetuximab in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Razak, Albiruni R. Abdul, Wang, Hung-Ming, Chang, Jang-Yang, Ahn, Myung-Ju, Munster, Pamela, Blumenschein, George, Solomon, Benjamin, Lim, Darren Wan-Teck, Hong, Ruey-Long, Pfister, David, Saba, Nabil F., Lee, Se-Hoon, van Herpen, Carla, Quadt, Cornelia, Bootle, Douglas, Blumenstein, Lars, Demanse, David, Delord, Jean-Pierre
Published in Targeted oncology (01.11.2023)
Published in Targeted oncology (01.11.2023)
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Phosphatidylinositol 3-Kinase α-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study
Juric, Dejan, Rodon, Jordi, Tabernero, Josep, Janku, Filip, Burris, Howard A, Schellens, Jan H M, Middleton, Mark R, Berlin, Jordan, Schuler, Martin, Gil-Martin, Marta, Rugo, Hope S, Seggewiss-Bernhardt, Ruth, Huang, Alan, Bootle, Douglas, Demanse, David, Blumenstein, Lars, Coughlin, Christina, Quadt, Cornelia, Baselga, José
Published in Journal of clinical oncology (01.05.2018)
Published in Journal of clinical oncology (01.05.2018)
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Population pharmacokinetics and pharmacodynamics of BYL 719, a phosphoinositide 3‐kinase antagonist, in adult patients with advanced solid malignancies
De Buck, Stefan S., Jakab, Annamaria, Boehm, Markus, Bootle, Douglas, Juric, Dejan, Quadt, Cornelia, Goggin, Timothy K.
Published in British journal of clinical pharmacology (01.09.2014)
Published in British journal of clinical pharmacology (01.09.2014)
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In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576
MISTRY, Prakash, STEWART, Alistair J, DANGERFIELD, Wendy, OKIJI, Sade, LIDDLE, Chris, BOOTLE, Douglas, PLUMB, Jane A, TEMPLETON, David, CHARLTON, Peter
Published in Cancer research (Chicago, Ill.) (15.01.2001)
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Published in Cancer research (Chicago, Ill.) (15.01.2001)
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Abstract PD5-5: Phase I study of the PI3Kα inhibitor BYL719 plus fulvestrant in patients with PIK3CA -altered and wild type ER+/HER2- locally advanced or metastatic breast cancer
Janku, Filip, Juric, Dejan, Cortes, Javier, Rugo, Hope, Burris, Howard A, Schuler, Martin, Deschler-Baier, Barbara, Middleton, Mark R, Gil-Martin, Marta, Berlin, Jordan, Winer, Eric, Bootle, Douglas, Blumenstein, Lars, Demanse, David, Coughlin, Christina, Quadt, Cornelia, Baselga, José
Published in Cancer research (Chicago, Ill.) (01.05.2015)
Published in Cancer research (Chicago, Ill.) (01.05.2015)
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Safety, pharmacokinetics, and preliminary activity of the α-specific PI3K inhibitor BYL719: Results from the first-in-human study
Gonzalez-Angulo, Ana M., Juric, Dejan, Argilés, Guillem, Schellens, Jan HM, Burris, Howard A., Berlin, Jordan, Middleton, Mark R., Schuler, Martin H., Geel, Robin Van, Helgason, Thorunn, Bootle, Douglas, Boehm, Markus, Goggin, Timothy K., Demanse, David, Quadt, Cornelia, Baselga, Jose
Published in Journal of clinical oncology (20.05.2013)
Published in Journal of clinical oncology (20.05.2013)
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Abstract LB-65: Towards defining the genetic framework for clinical response to treatment with BYL719, a PI3Kalpha-specific inhibitor
Rodon, Jordi, Juric, Dejan, Gonzalez-Angulo, Ana-Maria, Bendell, Johanna, Berlin, Jordan, Bootle, Douglas, Gravelin, Kathlene, Huang, Alan, Derti, Adnan, Lehar, Joseph, Würthner, Jens, Boehm, Markus, van Allen, Eliezer, Wagle, Nikhil, Garraway, Levi A., Yelensky, Roman, Stephens, Philip J., Miller, Vincent A., Schlegel, Robert, Quadt, Cornelia, Baselga, José
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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The Body Poetic: Laforgue's Translations of Whitman
Bootle, Samuel Douglas
Published in Dix-neuf : journal of the Society of Dix-Neuviémistes (02.01.2016)
Published in Dix-neuf : journal of the Society of Dix-Neuviémistes (02.01.2016)
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Antitumor activity of XR5944, a novel and potent topoisomerase poison
Stewart, A J, Mistry, P, Dangerfield, W, Bootle, D, Baker, M, Kofler, B, Okiji, S, Baguley, B C, Denny, W A, Charlton, P A
Published in Anti-cancer drugs (01.04.2001)
Published in Anti-cancer drugs (01.04.2001)
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In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II
Mistry, Prakash, Stewart, Alistair J, Dangerfield, Wendy, Baker, Mark, Liddle, Chris, Bootle, Douglas, Kofler, Bettina, Laurie, Deanne, Denny, William A, Baguley, Bruce, Charlton, Peter A
Published in Anti-cancer drugs (01.01.2002)
Published in Anti-cancer drugs (01.01.2002)
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