Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations
Choudhary, Gaurav S, Pellagatti, Andrea, Agianian, Bogos, Smith, Molly A, Bhagat, Tushar D, Gordon-Mitchell, Shanisha, Sahu, Srabani, Pandey, Sanjay, Shah, Nishi, Aluri, Srinivas, Aggarwal, Ritesh, Aminov, Sarah, Schwartz, Leya, Steeples, Violetta, Booher, Robert N, Ramachandra, Murali, Samson, Maria, Carbajal, Milagros, Pradhan, Kith, Bowman, Teresa V, Pillai, Manoj M, Will, Britta, Wickrema, Amittha, Shastri, Aditi, Bradley, Robert K, Martell, Robert E, Steidl, Ulrich G, Gavathiotis, Evripidis, Boultwood, Jacqueline, Starczynowski, Daniel T, Verma, Amit
Published in eLife (30.08.2022)
Published in eLife (30.08.2022)
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MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis
Booher, Robert N, Hatch, Harold, Dolinski, Brian M, Nguyen, Thi, Harmonay, Lauren, Al-Assaad, Ali-Samer, Ayers, Mark, Nebozhyn, Michael, Loboda, Andrey, Hirsch, Heather A, Zhang, Theresa, Shi, Bin, Merkel, Carrie E, Angagaw, Minilik H, Wang, Yaolin, Long, Brian J, Lennon, Xianlu Q, Miselis, Nathan, Pucci, Vincenzo, Monahan, James W, Lee, Junghoon, Kondic, Anna Georgieva, Im, Eun Kyung, Mauro, David, Blanchard, Rebecca, Gilliland, Gary, Fawell, Stephen E, Zawel, Leigh, Schuller, Alwin G, Strack, Peter
Published in PloS one (07.10.2014)
Published in PloS one (07.10.2014)
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Journal Article
Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies
Gummadi, Venkateshwar Rao, Boruah, Anima, Ainan, Bharathi Raja, Vare, Brahma Reddy, Manda, Srinivas, Gondle, Hari Prakash, Kumar, Shiva Nagendra, Mukherjee, Subhendu, Gore, Suraj T, Krishnamurthy, Narasimha Rao, Marappan, Sivapriya, Nayak, Shilpa S, Nellore, Kavitha, Balasubramanian, Wesley Roy, Bhumireddy, Archana, Giri, Sanjeev, Gopinath, Sreevalsam, Samiulla, Dodheri S, Daginakatte, Girish, Basavaraju, Aravind, Chelur, Shekar, Eswarappa, Rajesh, Belliappa, Charamanna, Subramanya, Hosahalli S, Booher, Robert N, Ramachandra, Murali, Samajdar, Susanta
Published in ACS medicinal chemistry letters (10.12.2020)
Published in ACS medicinal chemistry letters (10.12.2020)
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Journal Article
Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice
Bian, Feng, Nath, Rathna, Sobocinski, Gregg, Booher, Robert N., Lipinski, William J., Callahan, Michael J., Pack, Amy, Wang, Kevin K.-W., Walker, Lary C.
Published in Journal of comparative neurology (1911) (06.05.2002)
Published in Journal of comparative neurology (1911) (06.05.2002)
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Journal Article
The principles and technique of resection of soft parts for sarcoma. 1958
Bowden, Lemuel, Booher, Robert J
Published in Clinical orthopaedics and related research (01.09.2004)
Published in Clinical orthopaedics and related research (01.09.2004)
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Journal Article
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2
Lundgren, Karen, Walworth, Nancy, Booher, Robert, Dembski, Marlene, Kirschner, Marc, Beach, David
Published in Cell (22.03.1991)
Published in Cell (22.03.1991)
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Journal Article
Human Myt1 Is a Cell Cycle-regulated Kinase That Inhibits Cdc2 but Not Cdk2 Activity
Booher, Robert N., Holman, Patricia S., Fattaey, Ali
Published in The Journal of biological chemistry (29.08.1997)
Published in The Journal of biological chemistry (29.08.1997)
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Journal Article
Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models
Hu, Chaoxin, Dadon, Tikva, Chenna, Venugopal, Yabuuchi, Shinichi, Bannerji, Rajat, Booher, Robert, Strack, Peter, Azad, Nilofer, Nelkin, Barry D, Maitra, Anirban
Published in Molecular cancer therapeutics (01.07.2015)
Published in Molecular cancer therapeutics (01.07.2015)
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Journal Article
The fission yeast cdc2/cdc13/suc1 protein kinase: Regulation of catalytic activity and nuclear localization
Booher, Robert N., Alfa, Caroline E., Hyams, Jeremy S., Beach, David H.
Published in Cell (11.08.1989)
Published in Cell (11.08.1989)
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Journal Article
SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML
Choudhary, Gaurav S, Smith, Molly A, Pellagatti, Andrea, Bhagat, Tushar D, Gordon, Shanisha, Pandey, Sanjay, Shah, Nishi, Aluri, Srinivas, Booher, Robert N, Ramachandra, Murali, Samson, Maria Elena, Pradhan, Kith, Bowman, Teresa V., Pillai, Manoj M, Guha, Chandan, Wickrema, Amittha, Will, Britta, Shastri, Aditi, Steidl, Ulrich G., Boultwood, Jacqueline, Starczynowski, Daniel T., Verma, Amit
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Splicesome Mutant MDS and AML Cells Activate Innate Immune Signaling By Regulating the Expression of Therapeutically Targetable IRAK4 Isoforms
Smith, Molly A, Choudhary, Gaurav, Pellagatti, Andrea, Choi, Kwangmin, Bhagat, Tushar Damodar, Salomonis, Nathan, Walter, Matthew J., Komurov, Kakajan, Sampson, Maria Elena S, Gordon, Shanisha, Von Ahrens, Dagny, Pradhan, Kith, Steidl, Ulrich G., Booher, Robert, Boultwood, Jacqueline, Verma, Amit, Starczynowski, Daniel
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Preclinical Activity of IRAK4 Kinase Inhibitor CA-4948 Alone or in Combination with Targeted Therapies and Preliminary Phase 1 Clinical Results in Non-Hodgkin Lymphoma
Booher, Robert N, Nowakowski, Grzegorz S., Patel, Krish, Lunning, Matthew A., Samson, Maria Elena S., Atoyan, Ruzanna, Ma, Anna W, Xu, Guang-Xin, Dellarocca, Steven, Modafferi, Holly, Borek, Mylissa, Zhang, Zhidong, Parker, Jefferson, Whitney, Duncan, Wang, Hongwei, Tuck, David P, Younes, Anas
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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