Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis
Udler, Miriam S, Kim, Jaegil, von Grotthuss, Marcin, Bonàs-Guarch, Sílvia, Cole, Joanne B, Chiou, Joshua, Boehnke, Michael, Laakso, Markku, Atzmon, Gil, Glaser, Benjamin, Mercader, Josep M, Gaulton, Kyle, Flannick, Jason, Getz, Gad, Florez, Jose C
Published in PLoS medicine (21.09.2018)
Published in PLoS medicine (21.09.2018)
Get full text
Journal Article
Multiple genetic variants at the SLC30A8 locus affect local super‐enhancer activity and influence pancreatic β‐cell survival and function
Hu, Ming, Kim, Innah, Morán, Ignasi, Peng, Weicong, Sun, Orien, Bonnefond, Amélie, Khamis, Amna, Bonàs‐Guarch, Sílvia, Froguel, Philippe, Rutter, Guy A.
Published in The FASEB journal (30.04.2024)
Published in The FASEB journal (30.04.2024)
Get full text
Journal Article
Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems
Mercader, Josep M, Puiggros, Montserrat, Segrè, Ayellet V, Planet, Evarist, Sorianello, Eleonora, Sebastian, David, Rodriguez-Cuenca, Sergio, Ribas, Vicent, Bonàs-Guarch, Sílvia, Draghici, Sorin, Yang, Chenjing, Mora, Sílvia, Vidal-Puig, Antoni, Dupuis, Josée, Florez, Jose C, Zorzano, Antonio, Torrents, David
Published in PLoS genetics (01.12.2012)
Published in PLoS genetics (01.12.2012)
Get full text
Journal Article
The impact of non-additive genetic associations on age-related complex diseases
Guindo-Martínez, Marta, Amela, Ramon, Bonàs-Guarch, Silvia, Puiggròs, Montserrat, Salvoro, Cecilia, Miguel-Escalada, Irene, Carey, Caitlin E., Cole, Joanne B., Rüeger, Sina, Atkinson, Elizabeth, Leong, Aaron, Sanchez, Friman, Ramon-Cortes, Cristian, Ejarque, Jorge, Palmer, Duncan S., Kurki, Mitja, Aragam, Krishna, Florez, Jose C., Badia, Rosa M., Mercader, Josep M., Torrents, David
Published in Nature communications (23.04.2021)
Published in Nature communications (23.04.2021)
Get full text
Journal Article
TIGER: The gene expression regulatory variation landscape of human pancreatic islets
Alonso, Lorena, Piron, Anthony, Morán, Ignasi, Guindo-Martínez, Marta, Bonàs-Guarch, Sílvia, Atla, Goutham, Miguel-Escalada, Irene, Royo, Romina, Puiggròs, Montserrat, Garcia-Hurtado, Xavier, Suleiman, Mara, Marselli, Lorella, Esguerra, Jonathan L.S., Turatsinze, Jean-Valéry, Torres, Jason M., Nylander, Vibe, Chen, Ji, Eliasson, Lena, Defrance, Matthieu, Amela, Ramon, Mulder, Hindrik, Gloyn, Anna L., Groop, Leif, Marchetti, Piero, Eizirik, Decio L., Ferrer, Jorge, Mercader, Josep M., Cnop, Miriam, Torrents, David
Published in Cell reports (Cambridge) (12.10.2021)
Published in Cell reports (Cambridge) (12.10.2021)
Get full text
Journal Article
CRISPR-based genome editing in primary human pancreatic islet cells
Bevacqua, Romina J., Dai, Xiaoqing, Lam, Jonathan Y., Gu, Xueying, Friedlander, Mollie S. H., Tellez, Krissie, Miguel-Escalada, Irene, Bonàs-Guarch, Silvia, Atla, Goutham, Zhao, Weichen, Kim, Seung Hyun, Dominguez, Antonia A., Qi, Lei S., Ferrer, Jorge, MacDonald, Patrick E., Kim, Seung K.
Published in Nature communications (23.04.2021)
Published in Nature communications (23.04.2021)
Get full text
Journal Article
Pancreatic microexons regulate islet function and glucose homeostasis
Juan-Mateu, Jonàs, Bajew, Simon, Miret-Cuesta, Marta, Íñiguez, Luis P, Lopez-Pascual, Amaya, Bonnal, Sophie, Atla, Goutham, Bonàs-Guarch, Sílvia, Ferrer, Jorge, Valcárcel, Juan, Irimia, Manuel
Published in Nature metabolism (01.02.2023)
Published in Nature metabolism (01.02.2023)
Get more information
Journal Article
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
Bønnelykke, Klaus, Sleiman, Patrick, Nielsen, Kasper, Kreiner-Møller, Eskil, Mercader, Josep M, Belgrave, Danielle, den Dekker, Herman T, Husby, Anders, Sevelsted, Astrid, Faura-Tellez, Grissel, Mortensen, Li Juel, Paternoster, Lavinia, Flaaten, Richard, Mølgaard, Anne, Smart, David E, Thomsen, Philip F, Rasmussen, Morten A, Bonàs-Guarch, Silvia, Holst, Claus, Nohr, Ellen A, Yadav, Rachita, March, Michael E, Blicher, Thomas, Lackie, Peter M, Jaddoe, Vincent W V, Simpson, Angela, Holloway, John W, Duijts, Liesbeth, Custovic, Adnan, Davies, Donna E, Torrents, David, Gupta, Ramneek, Hollegaard, Mads V, Hougaard, David M, Hakonarson, Hakon, Bisgaard, Hans
Published in Nature genetics (01.01.2014)
Published in Nature genetics (01.01.2014)
Get full text
Journal Article
Genetic regulation of RNA splicing in human pancreatic islets
Atla, Goutham, Bonàs-Guarch, Silvia, Cuenca-Ardura, Mirabai, Beucher, Anthony, Crouch, Daniel J M, Garcia-Hurtado, Javier, Moran, Ignasi, Irimia, Manuel, Prasad, Rashmi B, Gloyn, Anna L, Marselli, Lorella, Suleiman, Mara, Berney, Thierry, de Koning, Eelco J P, Kerr-Conte, Julie, Pattou, Francois, Todd, John A, Piemonti, Lorenzo, Ferrer, Jorge
Published in Genome Biology (15.09.2022)
Published in Genome Biology (15.09.2022)
Get full text
Journal Article
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
Bonàs-Guarch, Sílvia, Guindo-Martínez, Marta, Miguel-Escalada, Irene, Grarup, Niels, Sebastian, David, Rodriguez-Fos, Elias, Sánchez, Friman, Planas-Fèlix, Mercè, Cortes-Sánchez, Paula, González, Santi, Timshel, Pascal, Pers, Tune H., Morgan, Claire C., Moran, Ignasi, Atla, Goutham, González, Juan R., Puiggros, Montserrat, Martí, Jonathan, Andersson, Ehm A., Díaz, Carlos, Badia, Rosa M., Udler, Miriam, Leong, Aaron, Kaur, Varindepal, Flannick, Jason, Jørgensen, Torben, Linneberg, Allan, Jørgensen, Marit E., Witte, Daniel R., Christensen, Cramer, Brandslund, Ivan, Appel, Emil V., Scott, Robert A., Luan, Jian’an, Langenberg, Claudia, Wareham, Nicholas J., Pedersen, Oluf, Zorzano, Antonio, Florez, Jose C, Hansen, Torben, Ferrer, Jorge, Mercader, Josep Maria, Torrents, David
Published in Nature communications (22.01.2018)
Published in Nature communications (22.01.2018)
Get full text
Journal Article
1643-P: A Recessive Genome-Wide Meta-analysis of Type 2 Diabetes in 300,000 Individuals of European Ancestry Identifies Multiple Novel Variants of Large Effect Size
O’CONNOR, MARK J., CORTES-SANCHEZ, PAULA, BONÀS-GUARCH, SÍLVIA, COLE, JOANNE B., TORRENTS, DAVID, LEONG, AARON, FLOREZ, JOSE C., MERCADER, JOSEP M.
Published in Diabetes (New York, N.Y.) (01.06.2020)
Published in Diabetes (New York, N.Y.) (01.06.2020)
Get full text
Journal Article
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
Bonàs Guarch, Sílvia, Guindo-Martínez, Marta, Miguel-Escalada, Irene, Grarup, Niels, Sebastián Muñoz, David, Rodriguez-Fos, Elias, Sánchez, Friman, Planas-Fèlix, Mercè, Cortes-Sánchez, Paula, González, Santi, Timshel, Pascal, Pers, Tune H, Morgan, Claire C, Moran, Ignasi, Atla, Goutham, González, Juan Ramón, Puiggros, Montserrat, Martí, Jonathan, Andersson, Ehm A, Díaz, Carlos, Badia, Rosa M, Udler, Miriam, Leong, Aaron, Kaur, Varindepal, Flannick, Jason, Jørgensen, Torben, Linneberg, Allan, Jørgensen, Marit E, Witte, Daniel R, Christensen, Cramer, Brandslund, Ivan, Appel, Emil V, Scott, Robert A, Luan, Jian'an, Langenberg, Claudia, Wareham, Nicholas J, Pedersen, Oluf, Zorzano Olarte, Antonio, Florez, Jose C, Hansen, Torben
Published in Nature communications (22.01.2018)
Get full text
Published in Nature communications (22.01.2018)
Journal Article
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
Bonàs Guarch, Sílvia, Guindo-Martínez, Marta, Miguel-Escalada, Irene, Grarup, Niels, Sebastián Muñoz, David, Rodriguez-Fos, Elias, Sánchez, Friman, Planas-Fèlix, Mercè, Cortes-Sánchez, Paula, González, Santi, Timshel, Pascal, Pers, Tune H, Morgan, Claire C, Moran, Ignasi, Atla, Goutham, González, Juan Ramón, Puiggros, Montserrat, Martí, Jonathan, Andersson, Ehm A, Díaz, Carlos, Badia, Rosa M, Udler, Miriam, Leong, Aaron, Kaur, Varindepal, Flannick, Jason, Jørgensen, Torben, Linneberg, Allan, Jørgensen, Marit E, Witte, Daniel R, Christensen, Cramer, Brandslund, Ivan, Appel, Emil V, Scott, Robert A, Luan, Jian'an, Langenberg, Claudia, Wareham, Nicholas J, Pedersen, Oluf, Zorzano Olarte, Antonio, Florez, Jose C, Hansen, Torben
Published in Nature communications (30.05.2018)
Published in Nature communications (30.05.2018)
Get full text
Journal Article
Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
Bonàs-Guarch, Sílvia, Guindo-Martínez, Marta, Miguel-Escalada, Irene, Grarup, Niels, Sebastian, David, Rodriguez-Fos, Elias, Sánchez, Friman, Planas-Fèlix, Mercè, Cortes-Sánchez, Paula, González, Santi, Timshel, Pascal, Pers, Tune H., Morgan, Claire C., Moran, Ignasi, Atla, Goutham, González, Juan R., Puiggros, Montserrat, Martí, Jonathan, Andersson, Ehm A., Díaz, Carlos, Badia, Rosa M., Udler, Miriam, Leong, Aaron, Kaur, Varindepal, Flannick, Jason, Jørgensen, Torben, Linneberg, Allan, Jørgensen, Marit E., Witte, Daniel R., Christensen, Cramer, Brandslund, Ivan, Appel, Emil V., Scott, Robert A., Luan, Jian’an, Langenberg, Claudia, Wareham, Nicholas J., Pedersen, Oluf, Zorzano, Antonio, Florez, Jose C, Hansen, Torben, Ferrer, Jorge, Mercader, Josep Maria, Torrents, David
Published in Nature communications (30.05.2018)
Published in Nature communications (30.05.2018)
Get full text
Journal Article
Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes
O'Connor, Mark J, Schroeder, Philip, Huerta-Chagoya, Alicia, Cortés-Sánchez, Paula, Bonàs-Guarch, Silvía, Guindo-Martínez, Marta, Cole, Joanne B, Kaur, Varinderpal, Torrents, David, Veerapen, Kumar, Grarup, Niels, Kurki, Mitja, Rundsten, Carsten F, Pedersen, Oluf, Brandslund, Ivan, Linneberg, Allan, Hansen, Torben, Leong, Aaron, Florez, Jose C, Mercader, Josep M
Published in Diabetes (New York, N.Y.) (01.03.2022)
Published in Diabetes (New York, N.Y.) (01.03.2022)
Get full text
Journal Article
Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems
Mercader, Josep M, Puiggros, Montserrat, Segrè, Ayellet V, Planet, Evarist, Sorianello, Eleonora, Sebastian, David, Rodriguez Cuenca, Sergio, Ribas, Vicent, Bonàs Guarch, Sílvia, Draghici, Sorin, Yang, Chenjing, Mora, Sílvia, Vidal Puig, Antoni, Dupuis, Josée, Florez, José C, Zorzano Olarte, Antonio, Torrents Arenales, David, DIAGRAM Consortium, MITIN Consortium
Published in PLoS genetics (06.12.2012)
Get full text
Published in PLoS genetics (06.12.2012)
Journal Article
Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes
Miguel-Escalada, Irene, Bonàs-Guarch, Silvia, Cebola, Inês, Ponsa-Cobas, Joan, Mendieta-Esteban, Julen, Atla, Goutham, Javierre, Biola M., Rolando, Delphine M. Y., Farabella, Irene, Morgan, Claire C., García-Hurtado, Javier, Beucher, Anthony, Morán, Ignasi, Pasquali, Lorenzo, Ramos-Rodríguez, Mireia, Appel, Emil V. R., Linneberg, Allan, Gjesing, Anette P., Witte, Daniel R., Pedersen, Oluf, Grarup, Niels, Ravassard, Philippe, Torrents, David, Mercader, Josep M., Piemonti, Lorenzo, Berney, Thierry, de Koning, Eelco J. P., Kerr-Conte, Julie, Pattou, François, Fedko, Iryna O., Groop, Leif, Prokopenko, Inga, Hansen, Torben, Marti-Renom, Marc A., Fraser, Peter, Ferrer, Jorge
Published in Nature genetics (01.07.2019)
Published in Nature genetics (01.07.2019)
Get full text
Journal Article
Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus
Julià, Antonio, López-Longo, Francisco Javier, Pérez Venegas, José J, Bonàs-Guarch, Silvia, Olivé, Àlex, Andreu, José Luís, Aguirre-Zamorano, Mª Ángeles, Vela, Paloma, Nolla, Joan M, de la Fuente, José Luís Marenco, Zea, Antonio, Pego-Reigosa, José María, Freire, Mercedes, Díez, Elvira, Rodríguez-Almaraz, Esther, Carreira, Patricia, Blanco, Ricardo, Taboada, Víctor Martínez, López-Lasanta, María, Corbeto, Mireia López, Mercader, Josep M, Torrents, David, Absher, Devin, Marsal, Sara, Fernández-Nebro, Antonio
Published in Arthritis research & therapy (30.05.2018)
Published in Arthritis research & therapy (30.05.2018)
Get full text
Journal Article
Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes
Huerta-Chagoya, Alicia, Schroeder, Philip, Mandla, Ravi, Li, Jiang, Morris, Lowri, Vora, Maheak, Alkanaq, Ahmed, Nagy, Dorka, Szczerbinski, Lukasz, Madsen, Jesper G S, Bonàs-Guarch, Silvia, Mollandin, Fanny, Cole, Joanne B, Porneala, Bianca, Westerman, Kenneth, Li, Josephine H, Pollin, Toni I, Florez, Jose C, Gloyn, Anna L, Carey, David J, Cebola, Inês, Mirshahi, Uyenlinh L, Manning, Alisa K, Leong, Aaron, Udler, Miriam, Mercader, Josep M
Published in Nature genetics (08.10.2024)
Published in Nature genetics (08.10.2024)
Get full text
Journal Article
Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes
Miguel-Escalada, Irene, Bonàs-Guarch, Silvia, Cebola, Inês, Ponsa-Cobas, Joan, Mendieta-Esteban, Julen, Atla, Goutham, Javierre, Biola M., Rolando, Delphine M.Y., Farabella, Irene, Morgan, Claire C., García-Hurtado, Javier, Beucher, Anthony, Morán, Ignasi, Pasquali, Lorenzo, Ramos-Rodríguez, Mireia, Appel, Emil V.R., Linneberg, Allan, Gjesing, Anette P., Witte, Daniel R., Pedersen, Oluf, Grarup, Niels, Ravassard, Philippe, Torrents, David, Mercader, Josep M., Piemonti, Lorenzo, Berney, Thierry, de Koning, Eelco J.P., Kerr-Conte, Julie, Pattou, François, Fedko, Iryna O., Groop, Leif, Prokopenko, Inga, Hansen, Torben, Marti-Renom, Marc A., Fraser, Peter, Ferrer, Jorge
Published in Nature genetics (28.06.2019)
Published in Nature genetics (28.06.2019)
Get full text
Journal Article