Experimental illumination of a fitness landscape
Hietpas, Ryan T, Jensen, Jeffrey D, Bolon, Daniel N.A
Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2011)
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Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance
Shaqra, Ala M., Zvornicanin, Sarah N., Huang, Qiu Yu J., Lockbaum, Gordon J., Knapp, Mark, Tandeske, Laura, Bakan, David T., Flynn, Julia, Bolon, Daniel N. A., Moquin, Stephanie, Dovala, Dustin, Kurt Yilmaz, Nese, Schiffer, Celia A.
Published in Nature communications (21.06.2022)
Published in Nature communications (21.06.2022)
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Analyses of the Effects of All Ubiquitin Point Mutants on Yeast Growth Rate
Roscoe, Benjamin P., Thayer, Kelly M., Zeldovich, Konstantin B., Fushman, David, Bolon, Daniel N.A.
Published in Journal of molecular biology (26.04.2013)
Published in Journal of molecular biology (26.04.2013)
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A systematic survey of an intragenic epistatic landscape
Bank, Claudia, Hietpas, Ryan T, Jensen, Jeffrey D, Bolon, Daniel N A
Published in Molecular biology and evolution (01.01.2015)
Published in Molecular biology and evolution (01.01.2015)
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Mutational fitness landscape and drug resistance
Flynn, Julia, Samant, Neha, Schneider-Nachum, Gily, Tenzin, Tsepal, Bolon, Daniel N.A.
Published in Current opinion in structural biology (01.02.2023)
Published in Current opinion in structural biology (01.02.2023)
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Fitness analyses of all possible point mutations for regions of genes in yeast
Hietpas, Ryan, Roscoe, Benjamin, Jiang, Li, Bolon, Daniel N A
Published in Nature protocols (01.07.2012)
Published in Nature protocols (01.07.2012)
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Journal Article
Latent effects of Hsp90 mutants revealed at reduced expression levels
Jiang, Li, Mishra, Parul, Hietpas, Ryan T, Zeldovich, Konstantin B, Bolon, Daniel N A
Published in PLoS genetics (01.06.2013)
Published in PLoS genetics (01.06.2013)
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Journal Article
The Adaptive Potential of the Middle Domain of Yeast Hsp90
Cote-Hammarlof, Pamela A, Fragata, Inês, Flynn, Julia, Mavor, David, Zeldovich, Konstantin B, Bank, Claudia, Bolon, Daniel N A
Published in Molecular biology and evolution (01.02.2021)
Published in Molecular biology and evolution (01.02.2021)
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Sequence dependencies and biophysical features both govern cleavage of diverse cut‐sites by HIV protease
Samant, Neha, Nachum, Gily, Tsepal, Tenzin, Bolon, Daniel N. A.
Published in Protein science (01.07.2022)
Published in Protein science (01.07.2022)
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Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function
Mishra, Parul, Flynn, Julia M., Starr, Tyler N., Bolon, Daniel N.A.
Published in Cell reports (Cambridge) (19.04.2016)
Published in Cell reports (Cambridge) (19.04.2016)
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SHIFTING FITNESS LANDSCAPES IN RESPONSE TO ALTERED ENVIRONMENTS
Hietpas, Ryan T., Bank, Claudia, Jensen, Jeffrey D., Bolon, Daniel N. A.
Published in Evolution (01.12.2013)
Published in Evolution (01.12.2013)
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Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV‑1 Protease in Conferring Drug Resistance
Henes, Mina, Lockbaum, Gordon J, Kosovrasti, Klajdi, Leidner, Florian, Nachum, Gily S, Nalivaika, Ellen A, Lee, Sook-Kyung, Spielvogel, Ean, Zhou, Shuntai, Swanstrom, Ronald, Bolon, Daniel N.A, Kurt Yilmaz, Nese, Schiffer, Celia A
Published in ACS chemical biology (15.11.2019)
Published in ACS chemical biology (15.11.2019)
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Comprehensive fitness maps of Hsp90 show widespread environmental dependence
Flynn, Julia M, Rossouw, Ammeret, Cote-Hammarlof, Pamela, Fragata, Inês, Mavor, David, Hollins, 3rd, Carl, Bank, Claudia, Bolon, Daniel Na
Published in eLife (04.03.2020)
Published in eLife (04.03.2020)
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Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y
Jiang, Li, Samant, Neha, Liu, Ping, Somasundaran, Mohan, Jensen, Jeffrey D, Marasco, Wayne A, Kowalik, Timothy F, Schiffer, Celia A, Finberg, Robert W, Wang, Jennifer P, Bolon, Daniel N A
Published in Journal of virology (23.03.2022)
Published in Journal of virology (23.03.2022)
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An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy
Bank, Claudia, Renzette, Nicholas, Liu, Ping, Matuszewski, Sebastian, Shim, Hyunjin, Foll, Matthieu, Bolon, Daniel N. A., Zeldovich, Konstantin B., Kowalik, Timothy F., Finberg, Robert W., Wang, Jennifer P., Jensen, Jeffrey D.
Published in Evolution (01.11.2016)
Published in Evolution (01.11.2016)
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