Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain
Bolduc, David M., Montagna, Daniel R., Gu, Yongli, Selkoe, Dennis J., Wolfe, Michael S.
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2016)
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Journal Article
The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
Bolduc, David M, Montagna, Daniel R, Seghers, Matthew C, Wolfe, Michael S, Selkoe, Dennis J
Published in eLife (31.08.2016)
Published in eLife (31.08.2016)
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Journal Article
Identification of 2‑Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay
Parker, Mackenzie J., Lee, Hyelee, Yao, Shihua, Irwin, Sean, Hwang, Sunil, Belanger, Kylie, de Mare, Sofia Woo, Surgenor, Richard, Yan, Lu, Gee, Patricia, Morla, Shravan, Puyang, Xiaoling, Hsiao, Peng, Zeng, Hao, Zhu, Ping, Korpal, Manav, Dransfield, Paul, Bolduc, David M., Larsen, Nicholas A.
Published in Biochemistry (Easton) (18.07.2023)
Published in Biochemistry (Easton) (18.07.2023)
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Journal Article
Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4‑1 E3 Ligases
Chen, Zan, Thomas, Stefani N, Bolduc, David M, Jiang, Xuejun, Zhang, Xiangbin, Wolberger, Cynthia, Cole, Philip A
Published in Biochemistry (Easton) (05.07.2016)
Published in Biochemistry (Easton) (05.07.2016)
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Journal Article
The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity
Nguyen, Tuong-Vi, Yao, Shihua, Wang, Yahong, Rolfe, Alan, Selvaraj, Anand, Darman, Rachel, Ke, Jiyuan, Warmuth, Markus, Smith, Peter G., Larsen, Nicholas A., Yu, Lihua, Zhu, Ping, Fekkes, Peter, Vaillancourt, Frédéric H., Bolduc, David M.
Published in The Journal of biological chemistry (08.11.2019)
Published in The Journal of biological chemistry (08.11.2019)
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Journal Article
Use of Proteomic and Hematology Biomarkers for Prediction of Hematopoietic Acute Radiation Syndrome Severity in Baboon Radiation Models
Blakely, William F, Bolduc, David L, Debad, Jeff, Sigal, George, Port, Matthias, Abend, Michael, Valente, Marco, Drouet, Michel, Hérodin, Francis
Published in Health physics (1958) (01.07.2018)
Published in Health physics (1958) (01.07.2018)
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Journal Article
Testimonials to reconstruct past abundances of wildlife populations
Bolduc, David, Fauteux, Dominique, Gagnon, Catherine A., Gauthier, Gilles, Bêty, Joël, Legagneux, Pierre
Published in Basic and applied ecology (01.05.2023)
Published in Basic and applied ecology (01.05.2023)
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Journal Article
Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket
Yao, Shihua, Nguyen, Tuong-Vi, Rolfe, Alan, Agrawal, Anant A., Ke, Jiyuan, Peng, Shouyong, Colombo, Federico, Yu, Sean, Bouchard, Patricia, Wu, Jiayi, Huang, Kuan-Chun, Bao, Xingfeng, Omoto, Kiyoyuki, Selvaraj, Anand, Yu, Lihua, Ioannidis, Stephanos, Vaillancourt, Frédéric H., Zhu, Ping, Larsen, Nicholas A., Bolduc, David M.
Published in Cell chemical biology (19.03.2020)
Published in Cell chemical biology (19.03.2020)
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Journal Article
Identifying Circulating and Lung Tissue Cytokines Associated with Thoracic Irradiation and AEOL 10150 Treatment in a Nonhuman Primate Model
Cui, Wanchang, Hankey, Kim G, Zhang, Pei, Bolduc, David L, Bünger, Rolf, Xiao, Mang, Farese, Ann M, MacVittie, Thomas J
Published in Radiation research (08.07.2020)
Published in Radiation research (08.07.2020)
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Journal Article
Natural-history Characterization of a Murine Partial-body Irradiation Model System: Establishment of a Multiple-Parameter Based GI-ARS Severity-Scoring System
Bolduc, David L, Cary, Lynnette H, Kiang, Juliann G, Kurada, Lalitha, Kumar, Vidya P, Edma, Sunshine A, Olson, Matthew G, Vergara, Vernieda B, Bistline, Dalton D, Reese, Mario, Kenchegowda, Doreswamy, Hood, Maureen, Korotcov, Alexandru, Jaiswal, Shalini, Blakely, William F
Published in Radiation research (01.05.2024)
Published in Radiation research (01.05.2024)
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Journal Article
Structure of nicastrin unveils secrets of γ-secretase
Bolduc, David M., Wolfe, Michael S.
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.2014)
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Journal Article
Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation Alone and Followed by Wound Trauma
Kiang, Juliann G, Zhai, Min, Bolduc, David L, Smith, Joan T, Anderson, Marsha N, Ho, Connie, Lin, Bin, Jiang, Suping
Published in Radiation research (01.11.2017)
Published in Radiation research (01.11.2017)
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Journal Article
Captopril reduces lung inflammation and accelerated senescence in response to thoracic radiation in mice
Mungunsukh, Ognoon, George, Jeffy, McCart, Elizabeth A, Snow, Andrew L, Mattapallil, Joseph J, Mog, Steven R, Panganiban, Ronald Allan M, Bolduc, David L, Rittase, W Bradley, Bouten, Roxane M, Day, Regina M
Published in Journal of radiation research (01.03.2021)
Published in Journal of radiation research (01.03.2021)
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Journal Article
Urine Interleukin-18 (IL-18) as a Biomarker of Total-Body Irradiation: A Preliminary Study in Nonhuman Primates
Xiao, Mang, Bolduc, David L, Li, XiangHong, Cui, Wanchang, Hieber, Kevin P, Bünger, Rolf, Ossetrova, Natalia I
Published in Radiation research (01.09.2017)
Published in Radiation research (01.09.2017)
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Journal Article
Automated Dicentric Aberration Scoring for Triage Dose Assessment: 60Co Gamma Ray Dose-response at Different Dose Rates
Subramanian, Uma, O'Brien, Brett, McNamara, Maureen, Romanyukha, Lyudmila, Bolduc, David L, Olsen, Cara, Blakely, William F
Published in Health physics (1958) (01.07.2020)
Published in Health physics (1958) (01.07.2020)
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Journal Article
Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer
Furman, Craig, Puyang, Xiaoling, Zhang, Zhaojie, Wu, Zhenhua J, Banka, Deepti, Aithal, Kiran B, Albacker, Lee A, Hao, Ming-Hong, Irwin, Sean, Kim, Amy, Montesion, Meagan, Moriarty, Alyssa D, Murugesan, Karthikeyan, Nguyen, Tuong-Vi, Rimkunas, Victoria, Sahmoud, Tarek, Wick, Michael J, Yao, Shihua, Zhang, Xun, Zeng, Hao, Vaillancourt, Frédéric H, Bolduc, David M, Larsen, Nicholas, Zheng, Guo Zhu, Prajapati, Sudeep, Zhu, Ping, Korpal, Manav
Published in Molecular cancer therapeutics (01.06.2022)
Published in Molecular cancer therapeutics (01.06.2022)
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Journal Article
Structural basis of nSH2 regulation and lipid binding in PI3Kα
Miller, Michelle S, Schmidt-Kittler, Oleg, Bolduc, David M, Brower, Evan T, Chaves-Moreira, Daniele, Allaire, Marc, Kinzler, Kenneth W, Jennings, Ian G, Thompson, Philip E, Cole, Philip A, Amzel, L Mario, Vogelstein, Bert, Gabelli, Sandra B
Published in Oncotarget (30.07.2014)
Published in Oncotarget (30.07.2014)
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Journal Article