Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1
Ryan, Kevin, Bolaňos, Ben, Smith, Marissa, Palde, Prakash B., Cuenca, Paulina Delgado, VanArsdale, Todd L., Niessen, Sherry, Zhang, Lianglin, Behenna, Douglas, Ornelas, Martha A., Tran, Khanh T., Kaiser, Stephen, Lum, Lawrence, Stewart, Al, Gajiwala, Ketan S.
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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Journal Article
Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
Brooun, Alexei, Gajiwala, Ketan S., Deng, Ya-Li, Liu, Wei, Bolaños, Ben, Bingham, Patrick, He, You-Ai, Diehl, Wade, Grable, Nicole, Kung, Pei-Pei, Sutton, Scott, Maegley, Karen A., Yu, Xiu, Stewart, Al E.
Published in Nature communications (28.04.2016)
Published in Nature communications (28.04.2016)
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Journal Article
Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A
Quinlan, Casey L, Kaiser, Stephen E, Bolaños, Ben, Nowlin, Dawn, Grantner, Rita, Karlicek-Bryant, Shannon, Feng, Jun Li, Jenkinson, Stephen, Freeman-Cook, Kevin, Dann, Stephen G, Wang, Xiaoli, Wells, Peter A, Fantin, Valeria R, Stewart, Al E, Grant, Stephan K
Published in Nature chemical biology (01.07.2017)
Published in Nature chemical biology (01.07.2017)
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Journal Article
Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance
Schwartz, Phillip A., Kuzmic, Petr, Solowiej, James, Bergqvist, Simon, Bolanos, Ben, Almaden, Chau, Nagata, Asako, Ryan, Kevin, Feng, Junli, Dalvie, Deepak, Kath, John C., Xu, Meirong, Wani, Revati, Murray, Brion William
Published in Proceedings of the National Academy of Sciences - PNAS (07.01.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (07.01.2014)
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Journal Article
Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics
Orris, Benjamin, Huynh, Kevin W, Ammirati, Mark, Han, Seungil, Bolaños, Ben, Carmody, Jason, Petroski, Matthew D, Bosbach, Benedikt, Shields, David J, Stivers, James T
Published in Nucleic acids research (22.07.2022)
Published in Nucleic acids research (22.07.2022)
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Journal Article
The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase
Gajiwala, Ketan S., Grodsky, Neil, Bolaños, Ben, Feng, Junli, Ferre, RoseAnn, Timofeevski, Sergei, Xu, Meirong, Murray, Brion W., Johnson, Ted W., Stewart, Al
Published in The Journal of biological chemistry (22.09.2017)
Published in The Journal of biological chemistry (22.09.2017)
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Journal Article
Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2
Long, Yicheng, Bolanos, Ben, Gong, Lihu, Liu, Wei, Goodrich, Karen J, Yang, Xin, Chen, Siming, Gooding, Anne R, Maegley, Karen A, Gajiwala, Ketan S, Brooun, Alexei, Cech, Thomas R, Liu, Xin
Published in eLife (29.11.2017)
Published in eLife (29.11.2017)
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Journal Article
Development of a Potential High-Throughput Workflow to Characterize Sites of Bioconjugation by Immuno-Affinity Capture Coupled to MALDI-TOF Mass Spectrometry
Dai, Lan, Preston, Ryan, Bacica, Michael, Kinhikar, Arvind, Bolaños, Ben, Murphy, Robert E
Published in Bioconjugate chemistry (16.01.2013)
Published in Bioconjugate chemistry (16.01.2013)
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Journal Article
Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors
Falk, Matthew D, Liu, Wei, Bolaños, Ben, Unsal-Kacmaz, Keziban, Klippel, Anke, Grant, Stephan, Brooun, Alexei, Timofeevski, Sergei
Published in Bioscience reports (01.04.2014)
Published in Bioscience reports (01.04.2014)
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Journal Article
Reviving B‑Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase
Johnson, Ted W, Bolanos, Ben, Brooun, Alexei, Gallego, Rebecca A, Gehlhaar, Dan, Jalaie, Mehran, McTigue, Michele, Timofeevski, Sergei
Published in ACS medicinal chemistry letters (13.09.2018)
Published in ACS medicinal chemistry letters (13.09.2018)
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Journal Article
Structural and Biophysical Characterization of XIAP BIR3 G306E Mutant: Insights in Protein Dynamics and Application for Fragment-Based Drug Design
Moore, Cathy D, Wu, Haihong, Bolaños, Ben, Bergqvist, Simon, Brooun, Alexei, Pauly, Tom, Nowlin, Dawn
Published in Chemical biology & drug design (01.09.2009)
Published in Chemical biology & drug design (01.09.2009)
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Journal Article
Supercritical Fluid Chromatography Reduction of Hydrogen/Deuterium Back Exchange in Solution-Phase Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis
Emmett, Mark R, Kazazic, Sasa, Marshall, Alan G, Chen, Wei, Shi, Stone D.-H, Bolaños, Ben, Greig, Michael J
Published in Analytical chemistry (Washington) (01.10.2006)
Published in Analytical chemistry (Washington) (01.10.2006)
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Journal Article
Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1
Ryan, Kevin, Bolaňos, Ben, Smith, Marissa, Palde, Prakash, Cuenca, Paulina Delgado, VanArsdale, Todd L, Niessen, Sherry, Zhang, Lianglin, Behenna, Douglas, Ornelas, Martha A, Tran, Khanh T, Kaiser, Stephen, Lum, Lawrence, Stewart, Al, Gajiwala, Ketan S
Published in The Journal of biological chemistry (08.01.2021)
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Published in The Journal of biological chemistry (08.01.2021)
Journal Article
Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants
Greasley, Samantha E., Noell, Stephen, Plotnikova, Olga, Ferre, RoseAnn, Liu, Wei, Bolanos, Ben, Fennell, Kimberly, Nicki, Jennifer, Craig, Tim, Zhu, Yuao, Stewart, Al E., Steppan, Claire M.
Published in The Journal of biological chemistry (01.06.2022)
Published in The Journal of biological chemistry (01.06.2022)
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Journal Article
Abstract 330: Engineering electrophile-sensitive kinase mutants to accelerate oncology target validation
Oyer, Jon A., Johnson, Ted W., Wang, Andrew C., Maestre, Michael F., Flores-Bojorquez, Ana, Melnychuk, Roksolana, Timofeevski, Sergei, Niessen, Sherry, Wang, Zhenxiong, Li, Jian, Diehl, Wade C., Eisele, Koleen J., Lee, Nathan V., Zou, Aihua, Davis, Carl, Greenwald, Eric C., DeForest, Jacob, Ornelas, Martha, Li, Bryan, Scales, Stephanie, Khamphavong, Penney L., Ambler, Catherine M., Huang, Yun, Salomon-Ferrer, Romelia, Greasley, Samantha E., Bolanos, Ben, Grodsky, Neil, Lum, Lawrence, VanArsdale, Todd L., McAlpine, Indrawan J.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase
Johnson, Ted W., Bolanos, Ben, Brooun, Alexei, Gallego, Rebecca A., Gehlhaar, Dan, Jalaie, Mehran, McTigue, Michele, Timofeevski, Sergei
Published in ACS medicinal chemistry letters (09.08.2019)
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Published in ACS medicinal chemistry letters (09.08.2019)
Journal Article
Abstract 4456: Biochemical and structural characteristics of crizotinib-resistant ALK mutants
Timofeevski, Sergei, Liu, Wei, Deng, Ya-Li, Brooun, Alexei, Bergqvist, Simon, Karlicek, Shannon, Murray, Brion, Bolaños, Ben, McTigue, Michele
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
Development of a long acting human growth hormone analog suitable for once a week dosing
Palanki, Moorthy S.S., Bhat, Abhijit, Bolanos, Ben, Brunel, Florence, Del Rosario, Joselyn, Dettling, Danielle, Horn, Mark, Lappe, Rodney, Preston, Ryan, Sievers, Annette, Stankovic, Nebojsa, Woodnut, Gary, Chen, Gang
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
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Journal Article
Fourier transform ion cyclotron resonance mass spectrometry using atmospheric pressure photoionization for high-resolution analyses of corticosteroids
Greig, Michael J., Bolaños, Ben, Quenzer, Terri, Bylund, Jessica M. R.
Published in Rapid communications in mass spectrometry (01.01.2003)
Published in Rapid communications in mass spectrometry (01.01.2003)
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