The Biosynthetic Gene Cluster for the Polyketide Immunosuppressant Rapamycin
Schwecke, Torsten, Aparicio, Jesus F., Molnar, Istvan, Konig, Ariane, Khaw, Lake Ee, Haycock, Stephen F., Oliynyk, Markiyan, Caffrey, Patrick, Cortes, Jesus, Lester, John B., Bohm, Gunter A., Staunton, James, Leadlay, Peter F.
Published in Proceedings of the National Academy of Sciences - PNAS (15.08.1995)
Published in Proceedings of the National Academy of Sciences - PNAS (15.08.1995)
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New Rapamycin Derivatives by Precursor-Directed Biosynthesis
Lowden, Philip A.S, Böhm, Günter A, Metcalfe, Su, Staunton, James, Leadlay, Peter F
Published in Chembiochem : a European journal of chemical biology (02.04.2004)
Published in Chembiochem : a European journal of chemical biology (02.04.2004)
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Structure of a Novel Oligosaccharide-Mycosporine-Amino Acid Ultraviolet A/B Sunscreen Pigment from the Terrestrial Cyanobacterium Nostoc commune
Böhm, Günter A., Pfleiderer, Wolfgang, Böger, Peter, Scherer, Siegfried
Published in The Journal of biological chemistry (14.04.1995)
Published in The Journal of biological chemistry (14.04.1995)
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Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase We thank Dr. Bradley S. Moore for help with the deuterium NMR experiments. This work was supported by grants from The Wellcome Trust (to J.S. and P.F.L.) and from the NIH (AI20264 to H.G.F.)
Lowden, Philip A. S., Wilkinson, Barrie, Böhm, Günter A., Handa, Sandeep, Floss, Heinz G., Leadlay, Peter F., Staunton, James
Published in Angewandte Chemie International Edition (16.02.2001)
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Published in Angewandte Chemie International Edition (16.02.2001)
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Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase
Lowden, Philip A. S., Wilkinson, Barrie, Böhm, Günter A., Handa, Sandeep, Floss, Heinz G., Leadlay, Peter F., Staunton, James
Published in Angewandte Chemie (International ed.) (16.02.2001)
Published in Angewandte Chemie (International ed.) (16.02.2001)
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Mutational Biosynthesis of Novel Rapamycins by a Strain of Streptomyces hygroscopicus NRRL 5491 Disrupted inrapL, Encoding a Putative Lysine Cyclodeaminase
Lake Ee Khaw, Günter A. Böhm, Su Metcalfe, James Staunton, Peter F. Leadlay
Published in Journal of Bacteriology (15.02.1998)
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Published in Journal of Bacteriology (15.02.1998)
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The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus
König, A, Schwecke, T, Molnar, I, Böhm, G A, Lowden, P A, Staunton, J, Leadlay, P F
Published in European journal of biochemistry (15.07.1997)
Published in European journal of biochemistry (15.07.1997)
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Journal Article
Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase
Lowden, Philip A. S., Wilkinson, Barrie, Böhm, Günter A., Handa, Sandeep, Floss, Heinz G., Leadlay, Peter F., Staunton, James
Published in Angewandte Chemie (16.02.2001)
Published in Angewandte Chemie (16.02.2001)
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The nature of the starter unit for the rapamycin polyketide synthase
Lowden, PAS, Bohm, GA, Staunton, J, Leadlay, PF
Published in Angewandte Chemie International Edition (18.10.1996)
Published in Angewandte Chemie International Edition (18.10.1996)
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The Pipecolate‐Incorporating Enzyme for the Biosynthesis of the Immunosuppressant Rapamycin — Nucleotide Sequence Analysis, Disruption and Heterologous Expression of Rap P from Streptomyces Hygroscopicus
König, Ariane, Schwecke, Torsten, Molnár, Istvin, Böhm, Günter A., Lowden, Philip A. S., Staunton, James, Leadlay, Peter F.
Published in European journal of biochemistry (01.07.1997)
Published in European journal of biochemistry (01.07.1997)
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Journal Article
Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase
Lowden, Philip A. S., Wilkinson, Barrie, Böhm, Günter A., Handa, Sandeep, Floss, Heinz G., Leadlay, Peter F., Staunton, James
Published in Angewandte Chemie (16.02.2001)
Published in Angewandte Chemie (16.02.2001)
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