Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer
Lücking, Ulrich, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Denner, Karsten, Bömer, Ulf, Schäfer, Martina, Eis, Knut, Valencia, Ray, Ince, Stuart, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl, Klebl, Bert, Choidas, Axel, Nussbaumer, Peter, Baumann, Matthias, Schultz‐Fademrecht, Carsten, Rühter, Gerd, Eickhoff, Jan, Brands, Michael
Published in ChemMedChem (08.11.2017)
Published in ChemMedChem (08.11.2017)
Get full text
Journal Article
Development of a Radioimmunoassay for the Quantitative Determination of 8-Prenylnaringenin in Biological Matrices
Schaefer, Olaf, Bohlmann, Rolf, Schleuning, Wolf-Dieter, Schulze-Forster, Kai, Hümpel, Michael
Published in Journal of agricultural and food chemistry (20.04.2005)
Published in Journal of agricultural and food chemistry (20.04.2005)
Get full text
Journal Article
Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer
Lücking, Ulrich, Kosemund, Dirk, Böhnke, Niels, Lienau, Philip, Siemeister, Gerhard, Denner, Karsten, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Bömer, Ulf, Schäfer, Martina, Ince, Stuart, Mumberg, Dominik, Scholz, Arne, Izumi, Raquel, Hwang, Stuart, von Nussbaum, Franz
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
Get full text
Journal Article
Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase
Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
Get full text
Journal Article
Abstract 984: Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops
Luecking, Ulrich T., Scholz, Arne, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Lienau, Philip, Siemeister, Gerhard, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Valencia, Ray, Ince, Stuart, Nussbaum, Franz von, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
Optimization of allosteric MEK inhibitors. Part 2: Taming the sulfamide group balances compound distribution properties
Hartung, Ingo V., Hammer, Stefanie, Hitchcock, Marion, Neuhaus, Roland, Scholz, Arne, Siemeister, Gerhard, Bohlmann, Rolf, Hillig, Roman C., Pühler, Florian
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Get full text
Journal Article
Abstract 2828: Rapid identification of potent and highly selective, oral PTEFb Inhibitor BAY 1143572 with first in class potential
Luecking, Ulrich TJ, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Eis, Knut, Gnoth, Mark, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Valencia, Ray, Ince, Stuart, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl, Klebl, Bert, Choidas, Axel, Nussbaumer, Peter, Baumann, Matthias, Schultz-Fademrecht, Carsten, Ruehter, Gerd, Eickhoff, Jan, Brands, Michael
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
8-Prenyl naringenin is a potent ERα selective phytoestrogen present in hops and beer
Schaefer, Olaf, Hümpel, Michael, Fritzemeier, Karl-Heinrich, Bohlmann, Rolf, Schleuning, Wolf-Dieter
Published in Journal of steroid biochemistry and molecular biology (01.02.2003)
Published in Journal of steroid biochemistry and molecular biology (01.02.2003)
Get full text
Journal Article
Conference Proceeding
In vivo characterization of estrogen receptor modulators with reduced genomic versus nongenomic activity in vitro
Otto, Christiane, Fuchs, Iris, Altmann, Helga, Klewer, Mario, Schwarz, Gilda, Bohlmann, Rolf, Nguyen, Duy, Zorn, Ludwig, Vonk, Richardus, Prelle, Katja, Österman, Thua, Malmström, Chira, Fritzemeier, Karl-Heinrich
Published in The Journal of steroid biochemistry and molecular biology (01.07.2008)
Published in The Journal of steroid biochemistry and molecular biology (01.07.2008)
Get full text
Journal Article
Characterization of new estrogen receptor destabilizing compounds: Effects on estrogen-sensitive and tamoxifen-resistant breast cancer
HOFFMANN, Jens, BOHLMANN, Rolf, GIESCHEN, Hille, ULBRICH, Hannes-F, SCHNEIDER, Martin R, HEINRICH, Nikolaus, HOFMEISTER, Helmut, KROLL, Jörg, KÜNZER, Hermann, LICHTNER, Rosemarie B, NISHINO, Yuki, PARCZYK, Karsten, SAUER, Gerhard
Published in JNCI : Journal of the National Cancer Institute (04.02.2004)
Published in JNCI : Journal of the National Cancer Institute (04.02.2004)
Get full text
Journal Article
5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP
LIENAU PHILIP, BOEMER ULF, BOEHNKE NIELS, BOHLMANN ROLF, SIEMEISTER GERHARD, KOSEMUND DIRK, ZORN LUDWIG, SCHOLZ ARNE, LUECKING ULRICH
Year of Publication 22.07.2015
Get full text
Year of Publication 22.07.2015
Patent
N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP
LIENAU PHILIP, BOEMER ULF, BOEHNKE NIELS, BOHLMANN ROLF, SIEMEISTER GERHARD, KOSEMUND DIRK, ZORN LUDWIG, SCHOLZ ARNE, LUECKING ULRICH
Year of Publication 15.07.2015
Get full text
Year of Publication 15.07.2015
Patent
6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SAID 6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES, AND USE THEREOF TO PRODUCE DRUGS
MOELLER CARSTEN, BOHLMANN ROLF, WINTERMANTEL TIM, ZORN LUDWIG, NUBBEMEYER REINHARD, BOTHE ULRICH, TER LAAK ANTONIUS, WORTMANN LARS
Year of Publication 04.09.2014
Get full text
Year of Publication 04.09.2014
Patent
18-METHYL-6,7-METHYLENE-3-OXO-17-PREGN-4-ENE-21,17β-CARBOLACTONES, PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS AND USE THEREOF IN THE TREATMENT OF ENDOMETRIOSIS
GALLUS NORBERT, TEREBESI ILDIKO, KUHNKE JOACHIM, BOHLMANN ROLF, HUEBNER JAN, GASHAW ISABELLA, NUBBEMEYER REINHARD, FISCHER OLIVER MARTIN
Year of Publication 09.07.2014
Get full text
Year of Publication 09.07.2014
Patent
SUBSTITUTED IMIDAZOPYRIDAZINES
LIENAU PHILIP, KOPPITZ MARCUS, BOHLMANN ROLF, WENGNER ANTJE MARGRET, KOSEMUND DIRK, SIEMEISTER GERHARD, JAUTELAT ROLF, KLAR ULRICH
Year of Publication 14.03.2014
Get full text
Year of Publication 14.03.2014
Patent
SUBSTITUTED 4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES
BOEMER ULF, LIENAU PHILIP, BOHLMANN ROLF, GNOTH MARK JEAN, SIEMEISTER GERHARD, KOSEMUND DIRK, SCHOLZ ARNE, SCHULTZ FADEMRECHT CARSTEN, LUECKING ULRICH, RUEHTER GERD
Year of Publication 14.02.2014
Get full text
Year of Publication 14.02.2014
Patent
C-RING-SUBSTITUTED PREGN-4-ENE-21,17-CARBOLACTONE, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE LATTER
KUHNKE JOACHIM, RING SVEN, PRELLE KATJA, BOHLMANN ROLF, ZORN LUDWIG, BORDEN STEFFEN
Year of Publication 02.03.2011
Get full text
Year of Publication 02.03.2011
Patent