Development of Selective Phosphatidylinositol 5‑Phosphate 4‑Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode
Boffey, Helen K., Rooney, Timothy P. C., Willems, Henriette M. G., Edwards, Simon, Green, Christopher, Howard, Tina, Ogg, Derek, Romero, Tamara, Scott, Duncan E., Winpenny, David, Duce, James, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
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Journal Article
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules
Rooney, Timothy P. C., Aldred, Gregory G., Boffey, Helen K., Willems, Henriëtte M. G., Edwards, Simon, Chawner, Stephen J., Scott, Duncan E., Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Journal Article
Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor
Willems, Henriëtte M. G, Edwards, Simon, Boffey, Helen K, Chawner, Stephen J, Green, Christopher, Romero, Tamara, Winpenny, David, Skidmore, John, Clarke, Jonathan H, Andrews, Stephen P
Published in MedChemComm (25.05.2023)
Published in MedChemComm (25.05.2023)
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The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)
Aldred, Gregory G, Rooney, Timothy P. C, Willems, Henriette M. G, Boffey, Helen K, Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H, Andrews, Stephen P
Published in MedChemComm (18.10.2023)
Published in MedChemComm (18.10.2023)
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