Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
Martin, Laetitia J, Koegl, Manfred, Bader, Gerd, Cockcroft, Xiao-Ling, Fedorov, Oleg, Fiegen, Dennis, Gerstberger, Thomas, Hofmann, Marco H, Hohmann, Anja F, Kessler, Dirk, Knapp, Stefan, Knesl, Petr, Kornigg, Stefan, Müller, Susanne, Nar, Herbert, Rogers, Catherine, Rumpel, Klaus, Schaaf, Otmar, Steurer, Steffen, Tallant, Cynthia, Vakoc, Christopher R, Zeeb, Markus, Zoephel, Andreas, Pearson, Mark, Boehmelt, Guido, McConnell, Darryl
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Discovery of Novel Spiro[3H‑indole-3,2′-pyrrolidin]-2(1H)‑one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction
Gollner, Andreas, Rudolph, Dorothea, Arnhof, Heribert, Bauer, Markus, Blake, Sophia M, Boehmelt, Guido, Cockroft, Xiao-Ling, Dahmann, Georg, Ettmayer, Peter, Gerstberger, Thomas, Karolyi-Oezguer, Jale, Kessler, Dirk, Kofink, Christiane, Ramharter, Juergen, Rinnenthal, Jörg, Savchenko, Alexander, Schnitzer, Renate, Weinstabl, Harald, Weyer-Czernilofsky, Ulrike, Wunberg, Tobias, McConnell, Darryl B
Published in Journal of medicinal chemistry (23.11.2016)
Published in Journal of medicinal chemistry (23.11.2016)
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Expansion of DUB functionality generated by alternative isoforms - USP35, a case study
Leznicki, Pawel, Natarajan, Jayaprakash, Bader, Gerd, Spevak, Walter, Schlattl, Andreas, Abdul Rehman, Syed Arif, Pathak, Deepika, Weidlich, Simone, Zoephel, Andreas, Bordone, Marie C, Barbosa-Morais, Nuno L, Boehmelt, Guido, Kulathu, Yogesh
Published in Journal of cell science (15.05.2018)
Published in Journal of cell science (15.05.2018)
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Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria
Junk, Lukas, Schmiedel, Volker M., Guha, Somraj, Fischel, Katharina, Greb, Peter, Vill, Kristin, Krisilia, Violetta, van Geelen, Lasse, Rumpel, Klaus, Kaur, Parvinder, Krishnamurthy, Ramya V., Narayanan, Shridhar, Shandil, Radha Krishan, Singh, Mayas, Kofink, Christiane, Mantoulidis, Andreas, Biber, Philipp, Gmaschitz, Gerhard, Kazmaier, Uli, Meinhart, Anton, Leodolter, Julia, Hoi, David, Junker, Sabryna, Morreale, Francesca Ester, Clausen, Tim, Kalscheuer, Rainer, Weinstabl, Harald, Boehmelt, Guido
Published in Nature communications (05.03.2024)
Published in Nature communications (05.03.2024)
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Tumor cell‐specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
Peter, Stefanie, Bultinck, Jennyfer, Myant, Kevin, Jaenicke, Laura A, Walz, Susanne, Müller, Judith, Gmachl, Michael, Treu, Matthias, Boehmelt, Guido, Ade, Carsten P, Schmitz, Werner, Wiegering, Armin, Otto, Christoph, Popov, Nikita, Sansom, Owen, Kraut, Norbert, Eilers, Martin
Published in EMBO molecular medicine (01.12.2014)
Published in EMBO molecular medicine (01.12.2014)
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Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1
Blagoveshchenskaya, Anastasia, Cheong, Fei Ying, Rohde, Holger M, Glover, Greta, Knödler, Andreas, Nicolson, Teresa, Boehmelt, Guido, Mayinger, Peter
Published in The Journal of cell biology (25.02.2008)
Published in The Journal of cell biology (25.02.2008)
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BacPROTACs mediate targeted protein degradation in bacteria
Morreale, Francesca E., Kleine, Stefan, Leodolter, Julia, Junker, Sabryna, Hoi, David M., Ovchinnikov, Stepan, Okun, Anastasia, Kley, Juliane, Kurzbauer, Robert, Junk, Lukas, Guha, Somraj, Podlesainski, David, Kazmaier, Uli, Boehmelt, Guido, Weinstabl, Harald, Rumpel, Klaus, Schmiedel, Volker M., Hartl, Markus, Haselbach, David, Meinhart, Anton, Kaiser, Markus, Clausen, Tim
Published in Cell (23.06.2022)
Published in Cell (23.06.2022)
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BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, William, Koegl, Manfred, Roy, Michael J., Whitworth, Claire, Diers, Emelyne, Trainor, Nicole, Zollman, David, Steurer, Steffen, Karolyi-Oezguer, Jale, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Galant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Gerstberger, Thomas, Schnitzer, Renate, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Ehrenhöfer-Wölfer, Katharina, Wöhrle, Simon, Boehmelt, Guido, Rinnenthal, Joerg, Arnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B., Ciulli, Alessio
Published in Nature chemical biology (01.07.2019)
Published in Nature chemical biology (01.07.2019)
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Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers
Schick, Sandra, Rendeiro, André F., Runggatscher, Kathrin, Ringler, Anna, Boidol, Bernd, Hinkel, Melanie, Májek, Peter, Vulliard, Loan, Penz, Thomas, Parapatics, Katja, Schmidl, Christian, Menche, Jörg, Boehmelt, Guido, Petronczki, Mark, Müller, André C., Bock, Christoph, Kubicek, Stefan
Published in Nature genetics (01.09.2019)
Published in Nature genetics (01.09.2019)
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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
Hoi, David M., Junker, Sabryna, Junk, Lukas, Schwechel, Kristin, Fischel, Katharina, Podlesainski, David, Hawkins, Paige M.E., van Geelen, Lasse, Kaschani, Farnusch, Leodolter, Julia, Morreale, Francesca Ester, Kleine, Stefan, Guha, Somraj, Rumpel, Klaus, Schmiedel, Volker M., Weinstabl, Harald, Meinhart, Anton, Payne, Richard J., Kaiser, Markus, Hartl, Markus, Boehmelt, Guido, Kazmaier, Uli, Kalscheuer, Rainer, Clausen, Tim
Published in Cell (11.05.2023)
Published in Cell (11.05.2023)
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Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3
Böttcher, Jark, Dilworth, David, Reiser, Ulrich, Neumüller, Ralph A., Schleicher, Michael, Petronczki, Mark, Zeeb, Markus, Mischerikow, Nikolai, Allali-Hassani, Abdellah, Szewczyk, Magdalena M., Li, Fengling, Kennedy, Steven, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Brown, Peter J., Huber, Kilian V. M., Rogers, Catherine M., Wells, Carrow I., Fedorov, Oleg, Rumpel, Klaus, Zoephel, Andreas, Mayer, Moriz, Wunberg, Tobias, Böse, Dietrich, Zahn, Stephan, Arnhof, Heribert, Berger, Helmut, Reiser, Christoph, Hörmann, Alexandra, Krammer, Teresa, Corcokovic, Maja, Sharps, Bernadette, Winkler, Sandra, Häring, Daniela, Cockcroft, Xiao-Ling, Fuchs, Julian E., Müllauer, Barbara, Weiss-Puxbaum, Alexander, Gerstberger, Thomas, Boehmelt, Guido, Vakoc, Christopher R., Arrowsmith, Cheryl H., Pearson, Mark, McConnell, Darryl B.
Published in Nature chemical biology (01.08.2019)
Published in Nature chemical biology (01.08.2019)
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Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules
Gollner, Andreas, Rudolph, Dorothea, Weyer-Czernilofsky, Ulrike, Baumgartinger, Rosa, Jung, Peter, Weinstabl, Harald, Ramharter, Jürgen, Grempler, Rolf, Quant, Jens, Rinnenthal, Jörg, Pérez Pitarch, Alejandro, Golubovic, Bojana, Gerlach, Daniel, Bader, Gerd, Wetzel, Kristiane, Otto, Sebastian, Mandl, Christian, Boehmelt, Guido, McConnell, Darryl B, Kraut, Norbert, Sini, Patrizia
Published in Molecular cancer therapeutics (03.12.2024)
Published in Molecular cancer therapeutics (03.12.2024)
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Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage
Jackson, Mark, Ahmari, Niousha, Wu, Jianqiang, Rizvi, Tilat A., Fugate, Elizabeth, Kim, Mi-OK, Dombi, Eva, Arnhof, Heribert, Boehmelt, Guido, Düchs, Matthias J., Long, Clive J., Maier, Udo, Trapani, Francesca, Hofmann, Marco H., Ratner, Nancy
Published in The Journal of pharmacology and experimental therapeutics (01.05.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2023)
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Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15
Teyra, Joan, Singer, Alex U., Schmitges, Frank W., Jaynes, Patrick, Kit Leng Lui, Sarah, Polyak, Maria J., Fodil, Nassima, Krieger, Jonathan R., Tong, Jiefei, Schwerdtfeger, Carsten, Brasher, Bradley B., Ceccarelli, Derek F.J., Moffat, Jason, Sicheri, Frank, Moran, Michael F., Gros, Philippe, Eichhorn, Pieter J.A., Lenter, Martin, Boehmelt, Guido, Sidhu, Sachdev S.
Published in Structure (London) (02.04.2019)
Published in Structure (London) (02.04.2019)
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Systematic characterization of BAF mutations provides insights into intra-complex synthetic lethalities in human cancers
Schick, Sandra, Rendeiro, André F., Runggatscher, Kathrin, Ringler, Anna, Boidol, Bernd, Hinkel, Melanie, Májek, Peter, Vulliard, Loan, Penz, Thomas, Parapatics, Katja, Schmidl, Christian, Menche, Jörg, Boehmelt, Guido, Petronczki, Mark, Mueller, André C., Bock, Christoph, Kubicek, Stefan
Published in Nature genetics (19.08.2019)
Published in Nature genetics (19.08.2019)
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Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases
Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K, Baumann, Christoph, Rudolph, Dorothea, Baumgartinger, Rosa, Strauss, Eva, Haslinger, Christian, Tontsch-Grunt, Ulrike, Waizenegger, Irene C, Solca, Flavio, Bader, Gerd, Zoephel, Andreas, Treu, Matthias, Reiser, Ulrich, Garin-Chesa, Pilar, Boehmelt, Guido, Kraut, Norbert, Quant, Jens, Adolf, Günther R
Published in Molecular cancer therapeutics (01.10.2016)
Published in Molecular cancer therapeutics (01.10.2016)
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Cloning and Characterization of the Murine Glucosamine-6-phosphate Acetyltransferase EMeg32
Boehmelt, Guido, Fialka, Irene, Brothers, Greg, McGinley, Michael D., Patterson, Scott D., Mo, Rong, Hui, Chi Chung, Chung, Stephen, Huber, Lukas A., Mak, Tak W., Iscove, Norman N.
Published in The Journal of biological chemistry (28.04.2000)
Published in The Journal of biological chemistry (28.04.2000)
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Journal Article
Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, William, Koegl, Manfred, Roy, Michael J., Whitworth, Claire, Diers, Emelyne, Trainor, Nicole, Zollman, David, Steurer, Steffen, Karolyi-Oezguer, Jale, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Galant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Gerstberger, Thomas, Schnitzer, Renate, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Ehrenhöfer-Wölfer, Katharina, Wöhrle, Simon, Boehmelt, Guido, Rinnenthal, Joerg, Arnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B., Ciulli, Alessio
Published in Nature chemical biology (01.08.2019)
Published in Nature chemical biology (01.08.2019)
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Abstract 1919: Pharmacological characterization of BI 847325, a dual inhibitor of MEK and Aurora kinases
Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K., Boehmelt, Guido, Garin-Chesa, Pilar, Kraut, Nobert, Rudolph, Dorothea, Solca, Flavio, Tontsch-Grunt, Ulrike, Waizenegger, Irene C., Adolf, Günther R.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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