Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin
Hoy, Benjamin, Geppert, Tim, Boehm, Manja, Reisen, Felix, Plattner, Patrick, Gadermaier, Gabriele, Sewald, Norbert, Ferreira, Fatima, Briza, Peter, Schneider, Gisbert, Backert, Steffen, Wessler, Silja
Published in The Journal of biological chemistry (23.03.2012)
Published in The Journal of biological chemistry (23.03.2012)
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Journal Article
Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA
Harrer, Aileen, Bücker, Roland, Boehm, Manja, Zarzecka, Urszula, Tegtmeyer, Nicole, Sticht, Heinrich, Schulzke, Jörg D, Backert, Steffen
Published in Gut pathogens (13.02.2019)
Published in Gut pathogens (13.02.2019)
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Journal Article
Protease Activity of Campylobacter jejuni HtrA Modulates Distinct Intestinal and Systemic Immune Responses in Infected Secondary Abiotic IL-10 Deficient Mice
Schmidt, Anna-Maria, Escher, Ulrike, Mousavi, Soraya, Boehm, Manja, Backert, Steffen, Bereswill, Stefan, Heimesaat, Markus M
Published in Frontiers in cellular and infection microbiology (29.03.2019)
Published in Frontiers in cellular and infection microbiology (29.03.2019)
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Journal Article
Immunopathological properties of the Campylobacter jejuni flagellins and the adhesin CadF as assessed in a clinical murine infection model
Schmidt, Anna-Maria, Escher, Ulrike, Mousavi, Soraya, Tegtmeyer, Nicole, Boehm, Manja, Backert, Steffen, Bereswill, Stefan, Heimesaat, Markus M
Published in Gut pathogens (17.05.2019)
Published in Gut pathogens (17.05.2019)
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Journal Article
The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2
Krause-Gruszczynska, Malgorzata, Boehm, Manja, Rohde, Manfred, Tegtmeyer, Nicole, Takahashi, Seiichiro, Buday, Laszlo, Oyarzabal, Omar A, Backert, Steffen
Published in Cell communication and signaling (28.12.2011)
Published in Cell communication and signaling (28.12.2011)
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Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin
Boehm, Manja, Hoy, Benjamin, Rohde, Manfred, Tegtmeyer, Nicole, Bæk, Kristoffer T, Oyarzabal, Omar A, Brøndsted, Lone, Wessler, Silja, Backert, Steffen
Published in Gut pathogens (25.04.2012)
Published in Gut pathogens (25.04.2012)
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Journal Article
Major host factors involved in epithelial cell invasion of Campylobacter jejuni: role of fibronectin, integrin beta1, FAK, Tiam-1, and DOCK180 in activating Rho GTPase Rac1
Boehm, Manja, Krause-Gruszczynska, Malgorzata, Rohde, Manfred, Tegtmeyer, Nicole, Takahashi, Seiichiro, Oyarzabal, Omar A, Backert, Steffen
Published in Frontiers in cellular and infection microbiology (2011)
Published in Frontiers in cellular and infection microbiology (2011)
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Journal Article
The impact of serine protease HtrA in apoptosis, intestinal immune responses and extra-intestinal histopathology during Campylobacter jejuni infection of infant mice
Heimesaat, Markus M, Fischer, André, Alutis, Marie, Grundmann, Ursula, Boehm, Manja, Tegtmeyer, Nicole, Göbel, Ulf B, Kühl, Anja A, Bereswill, Stefan, Backert, Steffen
Published in Gut pathogens (27.05.2014)
Published in Gut pathogens (27.05.2014)
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Journal Article
Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery
Tegtmeyer, Nicole, Wessler, Silja, Necchi, Vittorio, Rohde, Manfred, Harrer, Aileen, Rau, Tilman T., Asche, Carmen Isabell, Boehm, Manja, Loessner, Holger, Figueiredo, Ceu, Naumann, Michael, Palmisano, Ralf, Solcia, Enrico, Ricci, Vittorio, Backert, Steffen
Published in Cell host & microbe (11.10.2017)
Published in Cell host & microbe (11.10.2017)
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Journal Article
Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations
Zawilak-Pawlik, Anna, Zarzecka, Urszula, Żyła-Uklejewicz, Dorota, Lach, Jakub, Strapagiel, Dominik, Tegtmeyer, Nicole, Böhm, Manja, Backert, Steffen, Skorko-Glonek, Joanna
Published in Scientific reports (13.08.2019)
Published in Scientific reports (13.08.2019)
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Journal Article
Campylobacter jejuni serine protease HtrA plays an important role in heat tolerance, oxygen resistance, host cell adhesion, invasion, and transmigration
Boehm, Manja, Lind, Judith, Backert, Steffen, Tegtmeyer, Nicole
Published in European journal of microbiology & immunology (01.03.2015)
Published in European journal of microbiology & immunology (01.03.2015)
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Journal Article
Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA
Schmidt, Thomas P., Perna, Anna M., Fugmann, Tim, Böhm, Manja, Jan Hiss, Haller, Sarah, Götz, Camilla, Tegtmeyer, Nicole, Hoy, Benjamin, Rau, Tilman T., Neri, Dario, Backert, Steffen, Schneider, Gisbert, Wessler, Silja
Published in Scientific reports (17.03.2016)
Published in Scientific reports (17.03.2016)
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Journal Article
Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor of Helicobacter Pylori HtrA
Perna, Anna M., Rodrigues, Tiago, Schmidt, Thomas P., Böhm, Manja, Stutz, Katharina, Reker, Daniel, Pfeiffer, Bernhard, Altmann, Karl-Heinz, Backert, Steffen, Wessler, Silja, Schneider, Gisbert
Published in Angewandte Chemie International Edition (24.08.2015)
Published in Angewandte Chemie International Edition (24.08.2015)
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Journal Article
Function of Serine Protease HtrA in the Lifecycle of the Foodborne Pathogen Campylobacter jejuni
Boehm, Manja, Simson, Daniel, Escher, Ulrike, Schmidt, Anna-Maria, Bereswill, Stefan, Tegtmeyer, Nicole, Backert, Steffen, Heimesaat, Markus M
Published in European journal of microbiology & immunology (01.09.2018)
Published in European journal of microbiology & immunology (01.09.2018)
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Journal Article
The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice
Heimesaat, Markus M, Alutis, Marie, Grundmann, Ursula, Fischer, André, Tegtmeyer, Nicole, Böhm, Manja, Kühl, Anja A, Göbel, Ulf B, Backert, Steffen, Bereswill, Stefan
Published in Frontiers in cellular and infection microbiology (10.06.2014)
Published in Frontiers in cellular and infection microbiology (10.06.2014)
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Journal Article
Extracellular secretion of protease HtrA from Campylobacter jejuni is highly efficient and independent of its protease activity and flagellum
Boehm, Manja, Haenel, Ingrid, Hoy, Benjamin, Brøndsted, Lone, Smith, Todd G, Hoover, Timothy, Wessler, Silja, Tegtmeyer, Nicole
Published in European journal of microbiology & immunology (01.09.2013)
Published in European journal of microbiology & immunology (01.09.2013)
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