Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition
Wilcken, Rainer, Wang, GuoZhen, Boeckler, Frank M, Fersht, Alan R
Published in Proceedings of the National Academy of Sciences - PNAS (21.08.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (21.08.2012)
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Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
Boeckler, Frank M, Joerger, Andreas C, Jaggi, Gaurav, Rutherford, Trevor J, Veprintsev, Dmitry B, Fersht, Alan R
Published in Proceedings of the National Academy of Sciences - PNAS (29.07.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (29.07.2008)
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In Silico Targeting of Fascin Protein for Cancer Therapy: Benchmarking, Virtual Screening and Molecular Dynamics Approaches
Hassan, Heba H A, Ismail, Muhammad I, Abourehab, Mohammed A S, Boeckler, Frank M, Ibrahim, Tamer M, Arafa, Reem K
Published in Molecules (Basel, Switzerland) (29.01.2023)
Published in Molecules (Basel, Switzerland) (29.01.2023)
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Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53
Joerger, Andreas C., Bauer, Matthias R., Wilcken, Rainer, Baud, Matthias G.J., Harbrecht, Hannes, Exner, Thomas E., Boeckler, Frank M., Spencer, John, Fersht, Alan R.
Published in Structure (London) (01.12.2015)
Published in Structure (London) (01.12.2015)
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Harnessing Fluorine–Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs
Bauer, Matthias R, Jones, Rhiannon N, Baud, Matthias G. J, Wilcken, Rainer, Boeckler, Frank M, Fersht, Alan R, Joerger, Andreas C, Spencer, John
Published in ACS chemical biology (19.08.2016)
Published in ACS chemical biology (19.08.2016)
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Quadruple Target Evaluation of Diversity-Optimized Halogen-Enriched Fragments (HEFLibs) Reveals Substantial Ligand Efficiency for AP2-Associated Protein Kinase 1 (AAK1)
Dammann, Marcel, Kramer, Markus, Zimmermann, Markus O, Boeckler, Frank M
Published in Frontiers in chemistry (02.02.2022)
Published in Frontiers in chemistry (02.02.2022)
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Discovery of Ircinianin Lactones B and C-Two New Cyclic Sesterterpenes from the Marine Sponge Ircinia wistarii
Majer, Thomas, Bhattarai, Keshab, Straetener, Jan, Pohlmann, Justus, Cahill, Patrick, Zimmermann, Markus O, Hübner, Marc P, Kaiser, Marcel, Svenson, Johan, Schindler, Michael, Brötz-Oesterhelt, Heike, Boeckler, Frank M, Gross, Harald
Published in Marine drugs (19.08.2022)
Published in Marine drugs (19.08.2022)
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Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2
Vogel, Simon M, Bauer, Matthias R, Joerger, Andreas C, Wilcken, Rainer, Brandt, Tobias, Veprintsev, Dmitry B, Rutherford, Trevor J, Fersht, Alan R, Boeckler, Frank M
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
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Machine learning estimates of natural product conformational energies
Rupp, Matthias, Bauer, Matthias R, Wilcken, Rainer, Lange, Andreas, Reutlinger, Michael, Boeckler, Frank M, Schneider, Gisbert
Published in PLoS computational biology (01.01.2014)
Published in PLoS computational biology (01.01.2014)
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The Symmetric Tetravalent Sulfhydryl-Specific Linker NATBA Facilitates a Combinatorial “Tool Kit” Strategy for Phage Display-Based Selection of Functionalized Bicyclic Peptides
Ernst, Christoph, Sindlinger, Julia, Schwarzer, Dirk, Koch, Pierre, Boeckler, Frank M
Published in ACS omega (31.10.2018)
Published in ACS omega (31.10.2018)
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Switching Between Bicyclic and Linear Peptides - The Sulfhydryl-Specific Linker TPSMB Enables Reversible Cyclization of Peptides
Ernst, Christoph, Heidrich, Johannes, Sessler, Catharina, Sindlinger, Julia, Schwarzer, Dirk, Koch, Pierre, Boeckler, Frank M
Published in Frontiers in chemistry (16.10.2018)
Published in Frontiers in chemistry (16.10.2018)
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Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c‑Jun N‑Terminal Kinase 3
Ansideri, Francesco, Macedo, Joana T, Eitel, Michael, El-Gokha, Ahmed, Zinad, Dhafer S, Scarpellini, Camilla, Kudolo, Mark, Schollmeyer, Dieter, Boeckler, Frank M, Blaum, Bärbel S, Laufer, Stefan A, Koch, Pierre
Published in ACS omega (31.07.2018)
Published in ACS omega (31.07.2018)
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Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes
Dammann, Marcel, Stahlecker, Jason, Zimmermann, Markus O., Klett, Theresa, Rotzinger, Kilian, Kramer, Markus, Coles, Murray, Stehle, Thilo, Boeckler, Frank M.
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53
Wilcken, Rainer, Liu, Xiangrui, Zimmermann, Markus O., Rutherford, Trevor J., Fersht, Alan R., Joerger, Andreas C., Boeckler, Frank M.
Published in Journal of the American Chemical Society (18.04.2012)
Published in Journal of the American Chemical Society (18.04.2012)
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